 Cathepsin B
"Cathepsin B" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A lysosomal cysteine proteinase with a specificity similar to that of PAPAIN. The enzyme is present in a variety of tissues and is important in many physiological and pathological processes. In pathology, cathepsin B has been found to be involved in DEMYELINATION; EMPHYSEMA; RHEUMATOID ARTHRITIS, and NEOPLASM INVASIVENESS.
| Descriptor ID |
D002401
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| MeSH Number(s) |
D08.811.277.656.224.125 D08.811.277.656.262.500.133 D08.811.277.656.300.200.133
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Cathepsin B".
Below are MeSH descriptors whose meaning is more specific than "Cathepsin B".
This graph shows the total number of publications written about "Cathepsin B" by people in this website by year, and whether "Cathepsin B" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1988 | 1 | 0 | 1 | | 1989 | 0 | 1 | 1 | | 1991 | 3 | 0 | 3 | | 1993 | 0 | 1 | 1 | | 1994 | 1 | 0 | 1 | | 2002 | 0 | 1 | 1 | | 2017 | 2 | 0 | 2 |
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Below are the most recent publications written about "Cathepsin B" by people in Profiles.
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Bakst RL, Xiong H, Chen CH, Deborde S, Lyubchik A, Zhou Y, He S, McNamara W, Lee SY, Olson OC, Leiner IM, Marcadis AR, Keith JW, Al-Ahmadie HA, Katabi N, Gil Z, Vakiani E, Joyce JA, Pamer E, Wong RJ. Inflammatory Monocytes Promote Perineural Invasion via CCL2-Mediated Recruitment and Cathepsin B Expression. Cancer Res. 2017 11 15; 77(22):6400-6414.
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Acar H, Samaeekia R, Schnorenberg MR, Sasmal DK, Huang J, Tirrell MV, LaBelle JL. Cathepsin-Mediated Cleavage of Peptides from Peptide Amphiphiles Leads to Enhanced Intracellular Peptide Accumulation. Bioconjug Chem. 2017 09 20; 28(9):2316-2326.
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Martinez O, Johnson J, Manicassamy B, Rong L, Olinger GG, Hensley LE, Basler CF. Zaire Ebola virus entry into human dendritic cells is insensitive to cathepsin L inhibition. Cell Microbiol. 2010 Feb; 12(2):148-57.
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Röcken C, Fändrich M, Stix B, Tannert A, Hortschansky P, Reinheckel T, Saftig P, Kähne T, Menard R, Ancsin JB, Bühling F. Cathepsin protease activity modulates amyloid load in extracerebral amyloidosis. J Pathol. 2006 Dec; 210(4):478-87.
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Bourguignon LY, Singleton PA, Diedrich F, Stern R, Gilad E. CD44 interaction with Na+-H+ exchanger (NHE1) creates acidic microenvironments leading to hyaluronidase-2 and cathepsin B activation and breast tumor cell invasion. J Biol Chem. 2004 Jun 25; 279(26):26991-7007.
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Lee JP, Gerin C, Bindokas VP, Miller R, Ghadge G, Roos RP. No correlation between aggregates of Cu/Zn superoxide dismutase and cell death in familial amyotrophic lateral sclerosis. J Neurochem. 2002 Sep; 82(5):1229-38.
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Mehtani S, Gong Q, Panella J, Subbiah S, Peffley DM, Frankfater A. In vivo expression of an alternatively spliced human tumor message that encodes a truncated form of cathepsin B. Subcellular distribution of the truncated enzyme in COS cells. J Biol Chem. 1998 May 22; 273(21):13236-44.
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Qian F, Chan SJ, Achkar C, Steiner DF, Frankfater A. Transcriptional regulation of cathepsin B expression in B16 melanomas of varying metastatic potential. Biochem Biophys Res Commun. 1994 Jul 15; 202(1):429-36.
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Ye SQ, Reardon CA, Getz GS. Inhibition of apolipoprotein E degradation in a post-Golgi compartment by a cysteine protease inhibitor. J Biol Chem. 1993 Apr 25; 268(12):8497-502.
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Qian F, Frankfater A, Steiner DF, Bajkowski AS, Chan SJ. Characterization of multiple cathepsin B mRNAs in murine B16a melanoma. Anticancer Res. 1991 Jul-Aug; 11(4):1445-51.
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