"Separase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Separase is a caspase-like cysteine protease, which plays a central role in triggering ANAPHASE by cleaving the SCC1/RAD21 subunit of the cohesin complex. Cohesin holds the sister CHROMATIDS together during METAPHASE and its cleavage results in chromosome segregation.
| Descriptor ID |
D064247
|
| MeSH Number(s) |
D08.811.277.656.262.500.792 D08.811.277.656.300.200.792 D12.776.167.552
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Separase".
Below are MeSH descriptors whose meaning is more specific than "Separase".
This graph shows the total number of publications written about "Separase" by people in this website by year, and whether "Separase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 1 | 1 |
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Below are the most recent publications written about "Separase" by people in Profiles.
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Separase is required for chromosome segregation during meiosis I in Caenorhabditis elegans. Curr Biol. 2001 Nov 27; 11(23):1825-35.