 Dosage Compensation, Genetic
"Dosage Compensation, Genetic" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Genetic mechanisms that allow GENES to be expressed at a similar level irrespective of their GENE DOSAGE. This term is usually used in discussing genes that lie on the SEX CHROMOSOMES. Because the sex chromosomes are only partially homologous, there is a different copy number, i.e., dosage, of these genes in males vs. females. In DROSOPHILA, dosage compensation is accomplished by hypertranscription of genes located on the X CHROMOSOME. In mammals, dosage compensation of X chromosome genes is accomplished by random X CHROMOSOME INACTIVATION of one of the two X chromosomes in the female.
| Descriptor ID |
D004303
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| MeSH Number(s) |
G05.355.315.203.249
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| Concept/Terms |
Dosage Compensation, Genetic- Dosage Compensation, Genetic
- Compensation, Genetic Dosage
- Genetic Dosage Compensation
- Genetic Dosage Compensations
- Gene Dosage Compensation
- Compensation, Gene Dosage
- Dosage Compensation, Gene
- Gene Dosage Compensations
- Dosage Compensation (Genetics)
- Compensation, Dosage (Genetics)
X-Chromosome Hypertranscription- X-Chromosome Hypertranscription
- X Chromosome Hypertranscription
- Hypertranscription, X-Chromosome
- Hypertranscription, X Chromosome
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Below are MeSH descriptors whose meaning is more general than "Dosage Compensation, Genetic".
Below are MeSH descriptors whose meaning is more specific than "Dosage Compensation, Genetic".
This graph shows the total number of publications written about "Dosage Compensation, Genetic" by people in this website by year, and whether "Dosage Compensation, Genetic" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1986 | 0 | 1 | 1 | | 1992 | 1 | 0 | 1 | | 1997 | 0 | 1 | 1 | | 2001 | 0 | 2 | 2 | | 2003 | 1 | 3 | 4 | | 2004 | 0 | 3 | 3 | | 2010 | 0 | 1 | 1 | | 2012 | 0 | 1 | 1 | | 2013 | 0 | 1 | 1 |
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Below are the most recent publications written about "Dosage Compensation, Genetic" by people in Profiles.
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Strome S, Kelly WG, Ercan S, Lieb JD. Regulation of the X chromosomes in Caenorhabditis elegans. Cold Spring Harb Perspect Biol. 2014 Mar 01; 6(3).
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Sex-specific pattern formation during early Drosophila development. Genetics. 2013 May; 194(1):163-73.
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Vielle A, Lang J, Dong Y, Ercan S, Kotwaliwale C, Rechtsteiner A, Appert A, Chen QB, Dose A, Egelhofer T, Kimura H, Stempor P, Dernburg A, Lieb JD, Strome S, Ahringer J. H4K20me1 contributes to downregulation of X-linked genes for C. elegans dosage compensation. PLoS Genet. 2012 Sep; 8(9):e1002933.
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Balakrishnan CN, Lin YC, London SE, Clayton DF. RNA-seq transcriptome analysis of male and female zebra finch cell lines. Genomics. 2012 Dec; 100(6):363-9.
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Gschwend AR, Weingartner LA, Moore RC, Ming R. The sex-specific region of sex chromosomes in animals and plants. Chromosome Res. 2012 Jan; 20(1):57-69.
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Deng X, Hiatt JB, Nguyen DK, Ercan S, Sturgill D, Hillier LW, Schlesinger F, Davis CA, Reinke VJ, Gingeras TR, Shendure J, Waterston RH, Oliver B, Lieb JD, Disteche CM. Evidence for compensatory upregulation of expressed X-linked genes in mammals, Caenorhabditis elegans and Drosophila melanogaster. Nat Genet. 2011 Oct 23; 43(12):1179-85.
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Ercan S, Lubling Y, Segal E, Lieb JD. High nucleosome occupancy is encoded at X-linked gene promoters in C. elegans. Genome Res. 2011 Feb; 21(2):237-44.
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London SE, Itoh Y, Lance VA, Wise PM, Ekanayake PS, Oyama RK, Arnold AP, Schlinger BA. Neural expression and post-transcriptional dosage compensation of the steroid metabolic enzyme 17beta-HSD type 4. BMC Neurosci. 2010 Apr 01; 11:47.
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Ercan S, Lieb JD. C. elegans dosage compensation: a window into mechanisms of domain-scale gene regulation. Chromosome Res. 2009; 17(2):215-27.
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Whittle CM, McClinic KN, Ercan S, Zhang X, Green RD, Kelly WG, Lieb JD. The genomic distribution and function of histone variant HTZ-1 during C. elegans embryogenesis. PLoS Genet. 2008 Sep 12; 4(9):e1000187.
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