 Kainic Acid
"Kainic Acid" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
(2S-(2 alpha,3 beta,4 beta))-2-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid. Ascaricide obtained from the red alga Digenea simplex. It is a potent excitatory amino acid agonist at some types of excitatory amino acid receptors and has been used to discriminate among receptor types. Like many excitatory amino acid agonists it can cause neurotoxicity and has been used experimentally for that purpose.
| Descriptor ID |
D007608
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| MeSH Number(s) |
D03.383.773.400
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| Concept/Terms |
Kainic Acid- Kainic Acid
- Acid, Kainic
- Digenic Acid
- Acid, Digenic
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Below are MeSH descriptors whose meaning is more general than "Kainic Acid".
Below are MeSH descriptors whose meaning is more specific than "Kainic Acid".
This graph shows the total number of publications written about "Kainic Acid" by people in this website by year, and whether "Kainic Acid" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1981 | 1 | 0 | 1 | | 1987 | 1 | 0 | 1 | | 1988 | 0 | 1 | 1 | | 1989 | 0 | 1 | 1 | | 1990 | 0 | 1 | 1 | | 1991 | 1 | 1 | 2 | | 1992 | 1 | 0 | 1 | | 1993 | 0 | 2 | 2 | | 1994 | 3 | 0 | 3 | | 1995 | 2 | 2 | 4 | | 1998 | 0 | 1 | 1 | | 1999 | 1 | 0 | 1 | | 2000 | 0 | 3 | 3 | | 2001 | 0 | 1 | 1 | | 2002 | 0 | 1 | 1 | | 2003 | 0 | 1 | 1 | | 2004 | 0 | 1 | 1 | | 2006 | 0 | 1 | 1 |
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Below are the most recent publications written about "Kainic Acid" by people in Profiles.
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Engelman HS, Anderson RL, Daniele C, Macdermott AB. Presynaptic alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors modulate release of inhibitory amino acids in rat spinal cord dorsal horn. Neuroscience. 2006 May 12; 139(2):539-53.
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Soares S, Traka M, von Boxberg Y, Bouquet C, Karagogeos D, Nothias F. Neuronal and glial expression of the adhesion molecule TAG-1 is regulated after peripheral nerve lesion or central neurodegeneration of adult nervous system. Eur J Neurosci. 2005 Mar; 21(5):1169-80.
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Tranberg M, Stridh MH, Guy Y, Jilderos B, Wigström H, Weber SG, Sandberg M. NMDA-receptor mediated efflux of N-acetylaspartate: physiological and/or pathological importance? Neurochem Int. 2004 Dec; 45(8):1195-204.
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Cheng Z, Zhang H, Yu J, Wurster RD, Gozal D. Attenuation of baroreflex sensitivity after domoic acid lesion of the nucleus ambiguus of rats. J Appl Physiol (1985). 2004 Mar; 96(3):1137-45.
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Möykkynen T, Korpi ER, Lovinger DM. Ethanol inhibits alpha-amino-3-hydyroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor function in central nervous system neurons by stabilizing desensitization. J Pharmacol Exp Ther. 2003 Aug; 306(2):546-55.
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Cheng Z, Guo SZ, Lipton AJ, Gozal D. Domoic acid lesions in nucleus of the solitary tract: time-dependent recovery of hypoxic ventilatory response and peripheral afferent axonal plasticity. J Neurosci. 2002 Apr 15; 22(8):3215-26.
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Zhang J, Zhang D, McQuade JS, Behbehani M, Tsien JZ, Xu M. c-fos regulates neuronal excitability and survival. Nat Genet. 2002 Apr; 30(4):416-20.
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Vandenberghe W, Bindokas VP, Miller RJ, Robberecht W, Brorson JR. Subcellular localization of calcium-permeable AMPA receptors in spinal motoneurons. Eur J Neurosci. 2001 Jul; 14(2):305-14.
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Vandenberghe W, Ihle EC, Patneau DK, Robberecht W, Brorson JR. AMPA receptor current density, not desensitization, predicts selective motoneuron vulnerability. J Neurosci. 2000 Oct 01; 20(19):7158-66.
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Hasegawa T, Doi K, Fuse Y, Fujii K, Uno Y, Nishimura H, Kubo T. Deafness induced up-regulation of GluR2/3 and NR1 in the spiral ganglion cells of the rat cochlea. Neuroreport. 2000 Aug 03; 11(11):2515-9.
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