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James Brorson

TitleProfessor
InstitutionUniversity of Chicago
DepartmentNeurology
AddressChicago IL 60637
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    Collapse Overview 
    Collapse overview
    Dr. Brorson is a neurologist specializing in vascular neurology, with over 25 years of patient care experience, as well as experience in basic and clinical research. His laboratory work focused on mechanisms of neuronal cell death pertinent to acute brain insults including ischemia, excitotoxicity, and metabolic derangements. His clinical interests focus on the treatment and prevention of stroke, and the management of diverse aspects of cerebrovascular disease, including carotid stenosis, intracranial arterial stenosis, intracranial aneurysms, hypercoagulable disorders, cerebral amyloid angiopathy, and stroke in the young. He has served as site PI for several clinical trials in secondary stroke prevention. Currently he is medical director of the University of Chicago Comprehensive Stroke Center, which cares for over 400 stroke patients annually.

    Collapse Biography 
    Collapse education and training
    University of Chicago, Chicago, ILPostdoctoral Fellowship03/1993Pharmacology & Physiology
    University of Pennsylvania, Philadelphia, PAResidency06/1989Neurology
    University of Chicago, Chicago, ILMD06/1985Medicine
    Princeton University, Princeton, NJAB06/1981Physics
    Collapse awards and honors
    2019Doroghazi Clinical Teaching Award, University of Chicago
    2018Department Teaching Award, University of Chicago
    2017Senior Faculty Scholar in the Bucksbaum Institute for Clinical Excellence, University of Chicago

    Collapse Research 
    Collapse research activities and funding
    R33NS135583     (BRORSON, JAMES R.)Dec 1, 2023 - Dec 31, 2028
    NIH
    Kinetic analysis of acute stroke secondary prevention trials: Insights from combined datasets guiding future trial design
    Role: Principal Investigator
    R61NS135583     (BRORSON, JAMES R.)Dec 1, 2023 - Nov 30, 2025
    NIH
    Kinetic analysis of acute stroke secondary prevention trials: Insights from combined datasets guiding future trial design
    Role: Principal Investigator
    R01NS036260     (BRORSON, JAMES R.)Aug 1, 1999 - Aug 31, 2007
    NIH
    AMPA RECEPTOR EXPRESSION AND SELECTIVE NEURONAL DEATH
    Role: Principal Investigator
    K08NS001630     (BRORSON, JAMES R.)Jun 1, 1993 - May 31, 1998
    NIH
    MECHANISMS OF EXCITOTOXIC DAMAGE IN CENTRAL NEURONS
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Khan F, Stretz C, Lewis S, Chahien D, Goldstein E, Siegler JE, Lineback CM, Eklund K, Khasiyev F, Al Kasab S, Culbertson CJ, D'Souza M, Stamm B, Ro J, Kerrigan D, Sharma R, Aboul-Nour H, Nahab F, Omran SS, Linares G, Sehgal S, Melkumova E, Singh E, Zha AM, Thottempudi N, Mannion S, Van Coevering R, Chen L, Thompson SL, Thon JM, Penckofer M, Yu W, Qdais AA, Jillella D, Sloane KL, Dumitrascu OM, Conyers FG, Talat F, Glover PA, Kang J, Patel V, Aziz Y, Zubair A, de Havenon A, Porto CV, Bowman A, Shahrivari M, Brorson JR, Liebeskind DS, Nedelcu S, Ali H, Abdalwahab A, Kam W, Nguyen TN, Herpich F, Farroqui M, Rojas-Soto D, Yaghi S. Comprehensive Diagnostic Evaluation and Risk of Recurrent Stroke After Embolic Stroke of Undetermined Source: Introducing the Concept of ESUS 2.0. J Am Heart Assoc. 2026 Sep 15; 15(18):e050182. PMID: 42714434.
      Citations:    
    2. Penckofer M, Siegler J, Goldstein ED, Murphy K, Smith M, Bowman A, Nahab F, Daniel JP, Stretz C, Mannion S, Gaudio E, Thacker Q, Nelson A, Sathya A, Kam W, Kang J, Ro J, Thompson SL, Glover P, Sehgal S, Conyers FG, Xi R, Sarkar M, Melkumova E, Abburi N, Rothstein A, Thottempudi N, Sharma R, Aboul-Nour H, Chen L, Farooqui M, Rozental SF, Dumitrascu OM, Sharief A, Kerrigan DLG, Almallouhi E, Al-Kasab S, Chionatos RA, Peshwe K, Luan C, Doolittle C, Lineback CM, Valhuerdi Porto C, Stamm B, Kala N, Nguyen T, Linares G, Khezri N, Zubair AS, Nedelcu S, Yaghi S, Van Coevering RJ, Eklund K, Khasiyev F, Herpich F, Brorson JR, Thon JM. Association Between Insurance Status on Risk of Stroke Recurrence with Incident Cryptogenic Stroke: A Secondary Analysis of the Cardiac Abnormalities in Stroke Prevention and Recurrence Study. Neuroepidemiology. 2026 Aug 31; 1. PMID: 42671949.
      Citations:    
    3. Kellogg C, Badillo Goicoechea E, Kim DD, Yaghi S, Chaturvedi S, Mehendale R, Orjuela K, Kass-Hout T, Morsi RZ, Morales J, Singh E, Jhaveri A, Prabhakaran S, Smith MM, Brorson JR, Golani S, Mazuera S, Kang R, Eltatawy A, Pillajo J, Siegler JE. Theoretical Cost-Effectiveness of PCSK9 Inhibitors in Stroke Due to Intracranial Atherosclerosis. JAMA Netw Open. 2026 05 01; 9(5):e2610707. PMID: 42084872; PMCID: PMC13147199.
      Citations:    Fields:    Translation:Humans
    4. Brorson JR, Beniwal S, Giurcanu M, Landron D, Landron S, Siegler JE, Prabhakaran S, Johnson JA. Creation of a Merged Harmonized Large Database of Subject-Level Data from Acute Secondary Prevention Studies in Minor Non-Cardioembolic Stroke or TIA. Int J Cerebrovasc Dis Stroke. 2026; 9. PMID: 42212235; PMCID: PMC13215695.
      Citations:    
    5. Morsi RZ, Zhang Y, Badillo Goicoechea E, Desai H, Kothari SA, Thind S, Baskaran AB, Chahine A, Siegler JE, Coleman ER, Brorson JR, Mansour A, Prabhakaran S, Kass-Hout T. Cost Effectiveness of Endovascular Thrombectomy for Large Ischemic Strokes: A US Healthcare Payer Markov Model Informed by Randomized Trials. Appl Health Econ Health Policy. 2026 07; 24(4):777-789. PMID: 41999462; PMCID: PMC13260269.
      Citations:    Fields:    Translation:Humans
    6. Kothari SA, Morsi RZ, Kozel OA, Baskaran A, Sehgal N, Verhagen Metman O, Desai H, Carrion-Penganos J, Thind S, Smith MM, Rana R, Chahine A, Zakaria J, Karar L, Sweid A, Siegler JE, Coleman ER, Brorson JR, Mendelson SJ, Mansour A, Prabhakaran S, Kass-Hout T. Comparing validated stroke screening scales for identifying large and medium vessel occlusions: a prospective observational cohort study. J Neurointerv Surg. 2025 Nov 18; 17(12):1320-1324. PMID: 39488340.
      Citations: 1     Fields:    Translation:HumansPHPublic Health
    7. Desai H, Viswanath V, Goicoechea EB, Morsi RZ, Kothari SA, Smith M, Rana R, Metman OV, Thind S, Thodupunoori S, Narala V, Chahine A, Zakaria J, Carrión-Penagos J, Baskaran A, Vayani OR, Tarabichi A, Siegler JE, Coleman ER, Brorson JR, Mendelson SJ, Mansour A, Prabhakaran S, Kass-Hout T. Comparative effectiveness of reduced dose Ticagrelor, full dose Ticagrelor, and Clopidogrel in acute stroke management. J Clin Neurosci. 2026 Jan; 143:111752. PMID: 41248560.
      Citations:    Fields:    Translation:HumansPHPublic Health
    8. Golani S, Kellogg C, Nguyen V, Thon JM, Carroll T, Patel K, Penckofer M, Dubinski M, Garfinkel L, Elgendy O, Mazuera S, Jhaveri A, Kothari S, Desai H, Smith MM, Morsi R, Singh E, Brorson JR, Prabhakaran S, Morales J, Javed A, Goicoechea EB, Roth WH, Siegler JE. Cervical Internal Carotid Artery Plaque Composition and Chronic White Matter Disease in Patients with Noncardioembolic Stroke: A Multicenter Analysis. Stroke Vasc Interv Neurol. 2025 Nov; 5(6):e002006. PMID: 41608711; PMCID: PMC12697610.
      Citations:    
    9. Cherian L, Agarwal P, Dhana K, Carey V, Espeland MA, Laranjo N, Reilly X, Hong C, Maung P, Hollings C, Lukaszewicz B, Ventrelle J, James J, Tran A, Basapur S, Holland T, Krueger KR, Liu X, Yang D, Brorson JR, Khatib R, Arfanakis K, Barnes LL, Tangney C, Aggarwal NT. Nutrition Effects on Brain Outcomes and Recovery in Stroke after Hospitalization (NOURISH): Randomized controlled trial protocol and rationale. Contemp Clin Trials. 2025 Nov; 158:108108. PMID: 41076115; PMCID: PMC12863194.
      Citations: 1     Fields:    Translation:HumansCTClinical Trials
    10. Smith MM, Brorson JR, Badillo Goicoechea E, Penckofer M, Eklund K, Stretz C, Lineback CM, Khasiyev F, Kerrigan D, Lewis S, Ali H, Aboul-Nour H, de Havenon A, Culbertson CJ, Melkumova E, Jillella D, Dumitrascu OM, Parikh P, Doolittle C, Yahnke I, Sathya A, Brown S, Kang J, Bowman A, Shahrivari M, Elangovan C, Sehgal S, Sloane KL, Alvi M, Krishnaiah B, Kam W, Kothari S, Abu Qdais A, Farooqui M, Nahab F, Quintela GA, Sharma R, Thottempudi N, Nedelcu S, Herpich F, Glover P, Chahien D, Liebeskind DS, Linares G, Daniel JP, Al Kasab S, Singh E, D'Souza M, Gaudio E, Aziz Y, Yaghi S, Kala N, Sarkar M, Goldstein ED, Chen L, Van Coevering R, Thon JM, Stamm B, Thompson SL, Siegler JE. Intracranial Occlusion in Cryptogenic Stroke Is Not Predictive of Recurrent Ischemic Stroke: A Propensity-Score Matched Analysis of the Cardiac Abnormalities in Stroke Prevention and Risk of Recurrence Study. J Am Heart Assoc. 2025 10 07; 14(19):e041500. PMID: 40996035; PMCID: PMC12684489.
      Citations:    Fields:    Translation:Humans
    11. Rana R, Chahine A, Morsi RZ, Thind S, Desai H, Kothari SA, Baskaran A, Falk S, Karar L, Polster SP, Siegler JE, Coleman ER, Brorson JR, Mansour A, Prabhakaran S, Kass-Hout T. Balloon guide catheter use for carotid body tumor embolization: A retrospective case series. Interv Neuroradiol. 2025 Jul 21; 15910199251359084. PMID: 40686296; PMCID: PMC12279776.
      Citations:    Fields:    
    12. Siegler JE, Goicoechea EB, Penckofer M, Eklund K, Yaghi S, Stretz C, Lineback CM, Stamm B, Peter S, D'Souza M, Conyers FG, Khasiyev F, Kerrigan D, Lewis S, Ali H, Aboul-Nour H, Sharma R, Nahab FB, Glover P, Thompson SL, Alshaer QN, Thottempudi N, de Havenon A, Culbertson CJ, Melkumova E, Chionatos RA, Jillella DV, Daniel JA, Ro J, Frankel MR, Dumitrascu OM, Brown S, Parikh P, Doolittle C, Yahnke I, Sathya A, Kang J, Kirchhoffer K, Bowman A, Smith MM, Brorson JR, Asabere A, Shahrivari M, Elangovan C, Sheibani N, Krishnaiah B, Gaudio E, Sloane KL, Rothstein A, Alvi MM, Annam S, Amankwah C, Kam W, Abburi N, Farooqui M, Rojas-Soto D, Molaie A, Khezri N, Zubair AS, Abbasi M, Van Coevering RJ, Chen L, Nedelcu S, Herpich F, Chahien D, Sehgal S, Liebeskind DS, Linares G, Zha A, Sarkar M, Xi R, Nelson A, Abu Qdais A, Al Kasab S, Singh E, Patel V, Aziz YN, Mehndiratta P, DeMarco A, Sharrief A, Cucchiara B, Salehi Omran S, Nguyen TN, Dubinski M, Ackerman J, Thon J. Outcomes of Patients With Embolic Stroke of Undetermined Source Treated With Antiplatelet Agents or Anticoagulation: A Multicenter Cohort Study. Neurology. 2025 Aug 12; 105(3):e213876. PMID: 40609061.
      Citations: 3     Fields:    Translation:Humans
    13. Siegler JE, Badillo Goicoechea E, Yaghi S, Morsi RZ, Arevalo A, Smith MM, Kothari S, Desai H, Sehgal N, Rana R, Kellogg CA, Jhaveri A, de Havenon A, Dunne T, Cameron K, Chaturvedi S, Ghannam M, Prabhakaran S, Coleman E, Brorson JR, Mehendale R, Kass-Hout T. Estimated Theoretical Benefit of Aggressive LDL Lowering in Patients With Symptomatic Intracranial Atherosclerosis. Neurology. 2025 Jul 08; 105(1):e213768. PMID: 40446174.
      Citations:    Fields:    Translation:HumansPHPublic HealthCTClinical Trials
    14. Azizi E, Prabhakaran S, Brorson JR. Statin initiation and early stroke recurrence in the Platelet-Oriented Inhibition in New TIA and Minor Ischemic Stroke Trial (POINT) trial population. J Stroke Cerebrovasc Dis. 2025 Jul; 34(7):108349. PMID: 40381866; PMCID: PMC12180576.
      Citations: 1     Fields:    Translation:HumansPHPublic HealthCTClinical Trials
    15. Aldaher B, Behera A, Morsi RZ, Adra S, Desai H, Kothari SA, Thind S, Chahine A, Carrión-Penagos J, Baskaran A, Rana R, Armbrecht ES, Siegler JE, Coleman ER, Brorson JR, Mendelson SJ, Mansour A, Prabhakaran S, Kass-Hout T. Endovascular thrombectomy for distal medium vessel occlusions: A literature review. J Stroke Cerebrovasc Dis. 2025 Jan; 34(1):108134. PMID: 39537042.
      Citations: 2     Fields:    Translation:Humans
    16. Siegler JE, Brorson JR. Device-Detected Atrial Fibrillation and the Impact of Prior Stroke in Stroke Prevention. J Am Heart Assoc. 2024 09 03; 13(17):e037124. PMID: 39190581; PMCID: PMC11646509.
      Citations: 2     Fields:    Translation:Humans
    17. Roth W, Lo E, De Leon O, Suriya S, Fakhri F, Brorson JR, Polster S, Kass-Hout T, Prabhakaran S, Siegler JE. Understanding the Relationship Between Cerebrovascular Disease and the Gut Microbiome. Stroke Vasc Interv Neurol. 2025 Jan; 5(1):e001272. PMID: 41608402; PMCID: PMC11864580.
      Citations:    
    18. Morsi RZ, Kothari SA, Thind S, Desai H, Polster SP, Goldenberg F, Coleman E, Brorson JR, Mendelson S, Mansour A, Prabhakaran S, Kass-Hout T. The Zoom RDL radial access system for neurointervention: An early single-center experience. J Neurointerv Surg. 2024 Feb 12; 16(3):266-271. PMID: 37236781.
      Citations: 5     Fields:    Translation:Humans
    19. Ang PS, Zhang DM, Azizi SA, Norton de Matos SA, Brorson JR. The glymphatic system and cerebral small vessel disease. J Stroke Cerebrovasc Dis. 2024 Mar; 33(3):107557. PMID: 38198946; PMCID: PMC11579894.
      Citations: 20     Fields:    Translation:Humans
    20. Desai H, Al-Salihi MM, Morsi RZ, Vayani OR, Kothari SA, Thind S, Carrión-Penagos J, Baskaran A, Tarabichi A, Bonderski VA, Siegler JE, Hahn M, Coleman ER, Brorson JR, Mendelson SJ, Mansour A, Dabus G, Hurley M, Prabhakaran S, Linfante I, Kass-Hout T. Intravenous cangrelor use for neuroendovascular procedures: a two-center experience and updated systematic review. Front Neurol. 2023; 14:1304599. PMID: 38116108; PMCID: PMC10728671.
      Citations: 4     
    21. Brorson JR, Giurcanu M, Prabhakaran S, Johnston SC. Vulnerable and Stabilized States After Cerebral Ischemic Events: Implications of Kinetic Modeling in the SOCRATES, POINT, and THALES Trials. Neurology. 2023 11 27; 101(22):e2205-e2214. PMID: 37857494; PMCID: PMC10727217.
      Citations: 1     Fields:    Translation:HumansCTClinical Trials
    22. Morsi RZ, Zhang Y, Carrión-Penagos J, Desai H, Tannous E, Kothari S, Khamis A, Darzi AJ, Tarabichi A, Bastin R, Hneiny L, Thind S, Coleman E, Brorson JR, Mendelson S, Mansour A, Prabhakaran S, Kass-Hout T. Endovascular Thrombectomy With or Without Thrombolysis for Stroke: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Neurohospitalist. 2024 Jan; 14(1):23-33. PMID: 38235037; PMCID: PMC10790620.
      Citations: 4     
    23. Kass-Hout T, Morsi RZ, Thind S, Karrison T, Lee H, Nahab F, Gupta R, Carrión-Penagos J, Awad IA, Coleman E, Brorson JR, McKoy C, Morales J, Mendelson S, Mansour A, Prabhakaran S. Underlying intracranial atherosclerotic disease is associated with worse outcomes in acute large vessel occlusion undergoing endovascular thrombectomy. J Stroke Cerebrovasc Dis. 2023 Aug; 32(8):107227. PMID: 37437522.
      Citations: 4     Fields:    Translation:Humans
    24. Patel K, Taneja K, Obusan MB, Yaghi S, Nguyen TN, Thon JM, Kass-Hout T, Brorson JR, Prabhakaran S, Siegler JE. Real-World Outcomes for Basilar Artery Occlusion Thrombectomy With Mild Deficits: The National Inpatient Sample. Stroke. 2023 08; 54(8):2031-2039. PMID: 37350272.
      Citations: 2     Fields:    Translation:Humans
    25. Morsi RZ, Zhang Y, Carrión-Penagos J, Desai H, Tannous E, Kothari S, Khamis AM, Darzi AJ, Tarabichi A, Bastin R, Hneiny L, Thind S, Coleman E, Brorson JR, Mendelson S, Mansour A, Prabhakaran S, Kass-Hout T. Endovascular thrombectomy with or without thrombolysis bridging in patients with acute ischaemic stroke: protocol for a systematic review, meta-analysis of randomised trials and cost-effectiveness analysis. BMJ Open. 2023 06 12; 13(6):e064322. PMID: 37308271; PMCID: PMC10277059.
      Citations: 3     Fields:    Translation:Humans
    26. Bourand N, Brorson JR. Predictors of very early stroke recurrence in the POINT trial population. BMC Neurol. 2022 May 14; 22(1):177. PMID: 35568804; PMCID: PMC9107185.
      Citations: 2     Fields:    Translation:HumansCTClinical Trials
    27. Bulwa ZB, Mendelson SJ, Brorson JR. Acute Secondary Prevention of Ischemic Stroke: Overlooked No Longer. Front Neurol. 2021; 12:701168. PMID: 34566845; PMCID: PMC8460867.
      Citations: 5     
    28. Brorson JR, Bulwa ZB. Two-State Kinetic Model of Rates of Stroke Recurrence in the POINT Study Population. Stroke. 2021 04; 52(4):1446-1449. PMID: 33596678.
      Citations: 3     Fields:    Translation:Humans
    29. Ortiz Garcia JG, Nathan S, Brorson JR. Neurologic complications of implantable devices. Handb Clin Neurol. 2021; 177:211-220. PMID: 33632440.
      Citations:    Fields:    Translation:Humans
    30. Loggini A, Del Brutto VJ, El Ammar F, Bulwa ZB, Saleh Velez F, McKoy C, Martinez RC, Brorson J, Goldenberg FD, Ardelt AA. Intracranial Hemorrhage in Hospitalized Patients: An Infrequently Studied Condition with High Mortality. Neurocrit Care. 2020 12; 33(3):725-731. PMID: 32212038.
      Citations: 3     Fields:    Translation:Humans
    31. Trifan G, Goldenberg FD, Caprio FZ, Biller J, Schneck M, Khaja A, Terna T, Brorson J, Lazaridis C, Bulwa Z, Alvarado Dyer R, Saleh Velez FG, Prabhakaran S, Liotta EM, Batra A, Reish NJ, Ruland S, Teitcher M, Taylor W, De la Pena P, Conners JJ, Grewal PK, Pinna P, Dafer RM, Osteraas ND, DaSilva I, Hall JP, John S, Shafi N, Miller K, Moustafa B, Vargas A, Gorelick PB, Testai FD. Characteristics of a Diverse Cohort of Stroke Patients with SARS-CoV-2 and Outcome by Sex. J Stroke Cerebrovasc Dis. 2020 Nov; 29(11):105314. PMID: 32951959; PMCID: PMC7486061.
      Citations: 17     Fields:    Translation:HumansPHPublic Health
    32. Bulwa Z, Saleh Velez FG, Brorson JR, Pinto CB. Ipsilateral Nonstenotic Carotid Disease in Minor Ischemic Stroke: an Exploratory Analysis of The POINT Randomized Clinical Trial. J Stroke Cerebrovasc Dis. 2020 Nov; 29(11):105115. PMID: 33066893.
      Citations: 4     Fields:    Translation:HumansPHPublic Health
    33. Marot JE, Rebeiz T, Kramer C, McKoy C, Brorson J, Goldenberg F, Liberman AL, Lee SK. WITHDRAWN: Neurological examination, rather than vascular risk factor assessment, serves to distinguish strokes from stroke mimics in a population with high prevalence of vascular risk factors. World Neurosurg. 2020 07 18. PMID: 32688035.
      Citations: 1     Fields:    
    34. El Ammar F, Ardelt A, Del Brutto VJ, Loggini A, Bulwa Z, Martinez RC, McKoy CJ, Brorson J, Mansour A, Goldenberg FD. BE-FAST: A Sensitive Screening Tool to Identify In-Hospital Acute Ischemic Stroke. J Stroke Cerebrovasc Dis. 2020 Jul; 29(7):104821. PMID: 32312632.
      Citations: 21     Fields:    Translation:Humans
    35. Bulwa Z, Del Brutto VJ, Loggini A, Ammar FE, Martinez RC, Christoforidis G, Brorson JR, Ardelt AA, Goldenberg FD. Mechanical Thrombectomy for Patients with In-Hospital Ischemic Stroke: A Case-Control Study. J Stroke Cerebrovasc Dis. 2020 May; 29(5):104692. PMID: 32085938.
      Citations: 5     Fields:    Translation:Humans
    36. Brorson JR, Cifu AS. Management of Patients With Acute Ischemic Stroke. JAMA. 2019 Aug 27; 322(8):777-778. PMID: 31318383.
      Citations: 3     Fields:    
    37. Del Brutto VJ, Ardelt A, Loggini A, Bulwa Z, El-Ammar F, Martinez RC, Brorson J, Goldenberg F. Clinical Characteristics and Emergent Therapeutic Interventions in Patients Evaluated through the In-hospital Stroke Alert Protocol. J Stroke Cerebrovasc Dis. 2019 May; 28(5):1362-1370. PMID: 30846245.
      Citations: 10     Fields:    Translation:Humans
    38. Wang Y, Choi Y, Gallardo J, Nwaneri I, Brorson JR. Low Yield of Extensive Workup for Embolic Sources in Lacunar Stroke Patients. J Stroke Cerebrovasc Dis. 2018 Jun; 27(6):1575-1581. PMID: 29426678.
      Citations: 1     Fields:    Translation:Humans
    39. Mera RM, Del Brutto VJ, Zambrano M, Brorson J, Del Brutto OH, Costa AF. Basilar Artery Dolichoectasia: Prevalence and Correlates With Markers of Cerebral Small Vessel Disease in Community-Dwelling Older Adults. J Stroke Cerebrovasc Dis. 2017 Dec; 26(12):2909-2914. PMID: 28869136.
      Citations: 16     Fields:    Translation:Humans
    40. Lukas RV, Blood AD, Brorson JR, Albert DVF. Ambulatory training in neurology education. J Neurol Sci. 2017 Jan 15; 372:506-509. PMID: 27838003.
      Citations: 3     Fields:    Translation:Humans
    41. Albert DV, Blood AD, Park YS, Brorson JR, Lukas RV. Breadth versus volume: Neurology outpatient clinic cases in medical education. J Clin Neurosci. 2016 Jun; 28:20-3. PMID: 26896906.
      Citations: 5     Fields:    Translation:Humans
    42. Lukas RV, Brorson J, Albert DV. Author Response: Rimas V. Lukas, James Brorson, Chicago; Dara V. Albert, Columbus, OH. Neurology. 2016 Jan 26; 86(4):403. PMID: 27213202.
      Citations:    Fields:    Translation:Humans
    43. Sethi NK, Lukas RV, Brorson J, Albert DV. Structure of neuroscience clerkships in medical schools and matching in neuromedicine. Neurology. 2016 Jan 26; 86(4):403. PMID: 26810425.
      Citations:    Fields:    Translation:Humans
    44. Blood AD, Park YS, Lukas RV, Brorson JR. Neurology objective structured clinical examination reliability using generalizability theory. Neurology. 2015 Nov 03; 85(18):1623-9. PMID: 26432851; PMCID: PMC4642144.
      Citations: 8     Fields:    Translation:Humans
    45. Albert DV, Yin H, Amidei C, Dixit KS, Brorson JR, Lukas RV. Structure of neuroscience clerkships in medical schools and matching in neuromedicine. Neurology. 2015 Jul 14; 85(2):172-6. PMID: 26070342.
      Citations: 11     Fields:    Translation:Humans
    46. Lukas RV, Cooper B, Morgan I, Brorson JR, Dong H, Sherer R. Attitudes toward neurosciences in medical students in Wuhan, China: a survey study. World Neurosurg. 2014 Sep-Oct; 82(3-4):266-9. PMID: 24954255.
      Citations: 8     Fields:    Translation:Humans
    47. Tsien MZ, Brorson JR, Lukas RV, Dawson EC. A 16-year-old male with dizziness, parasthesias, and ataxia. Pediatr Ann. 2014 May; 43(5):e116-9. PMID: 24877493.
      Citations:    Fields:    Translation:Humans
    48. Albert DV, Brorson JR, Amidei C, Lukas RV. Education research: case logs in the assessment of medical students in the neurology outpatient clinic. Neurology. 2014 Apr 22; 82(16):e138-41. PMID: 24753516; PMCID: PMC10695659.
      Citations: 4     Fields:    Translation:Humans
    49. Lin W, Wadlington NL, Chen L, Zhuang X, Brorson JR, Kang UJ. Loss of PINK1 attenuates HIF-1a induction by preventing 4E-BP1-dependent switch in protein translation under hypoxia. J Neurosci. 2014 Feb 19; 34(8):3079-89. PMID: 24553947; PMCID: PMC3931509.
      Citations: 26     Fields:    Translation:AnimalsCells
    50. Lukas RV, Blood A, Park YS, Brorson JR. Assessment of neurological clinical management reasoning in medical students. J Clin Neurosci. 2014 Jun; 21(6):919-22. PMID: 24308954.
      Citations: 4     Fields:    Translation:Humans
    51. Hodgson TS, Brorson JR, Ardelt AA, Lukas RV. Accrediting neurology fellowships accelerates subspecialization. Front Neurol. 2013; 4:94. PMID: 23888152; PMCID: PMC3719470.
      Citations: 1     
    52. Lukas RV, Adesoye T, Smith S, Blood A, Brorson JR. Student assessment by objective structured examination in a neurology clerkship. Neurology. 2012 Aug 14; 79(7):681-5. PMID: 22855865; PMCID: PMC3414663.
      Citations: 11     Fields:    Translation:Humans
    53. Leggett C, McGehee DS, Mastrianni J, Yang W, Bai T, Brorson JR. Tunicamycin produces TDP-43 cytoplasmic inclusions in cultured brain organotypic slices. J Neurol Sci. 2012 Jun 15; 317(1-2):66-73. PMID: 22459357; PMCID: PMC3359826.
      Citations: 12     Fields:    Translation:AnimalsCells
    54. Back A, Tupper KY, Bai T, Chiranand P, Goldenberg FD, Frank JI, Brorson JR. Ammonia-induced brain swelling and neurotoxicity in an organotypic slice model. Neurol Res. 2011 Dec; 33(10):1100-8. PMID: 22196764; PMCID: PMC3650023.
      Citations: 27     Fields:    Translation:Animals
    55. Li D, Bai T, Brorson JR. Adaptation to moderate hypoxia protects cortical neurons against ischemia-reperfusion injury and excitotoxicity independently of HIF-1a. Exp Neurol. 2011 Aug; 230(2):302-10. PMID: 21619879; PMCID: PMC3650025.
      Citations: 9     Fields:    Translation:AnimalsCells
    56. Jacob A, Brorson JR, Alexander JJ. Septic encephalopathy: inflammation in man and mouse. Neurochem Int. 2011 Mar; 58(4):472-6. PMID: 21219956.
      Citations: 32     Fields:    Translation:HumansAnimals
    57. Jacob A, Hack B, Bai T, Brorson JR, Quigg RJ, Alexander JJ. Inhibition of C5a receptor alleviates experimental CNS lupus. J Neuroimmunol. 2010 Apr 15; 221(1-2):46-52. PMID: 20207017; PMCID: PMC2902239.
      Citations: 26     Fields:    Translation:AnimalsCells
    58. Jacob A, Bao L, Brorson J, Quigg RJ, Alexander JJ. C3aR inhibition reduces neurodegeneration in experimental lupus. Lupus. 2010 Jan; 19(1):73-82. PMID: 19900981; PMCID: PMC2952506.
      Citations: 21     Fields:    Translation:AnimalsCells
    59. Jiao J, Nakajima A, Janssen WG, Bindokas VP, Xiong X, Morrison JH, Brorson JR, Tang YP. Expression of NR2B in cerebellar granule cells specifically facilitates effect of motor training on motor learning. PLoS One. 2008 Feb 27; 3(2):e1684. PMID: 18301761; PMCID: PMC2246013.
      Citations: 5     Fields:    Translation:AnimalsCells
    60. Li D, Shao Z, Vanden Hoek TL, Brorson JR. Reperfusion accelerates acute neuronal death induced by simulated ischemia. Exp Neurol. 2007 Aug; 206(2):280-7. PMID: 17599834; PMCID: PMC3648807.
      Citations: 18     Fields:    Translation:AnimalsCells
    61. Young KC, McGehee DS, Brorson JR. Glutamate receptor expression and chronic glutamate toxicity in rat motor cortex. Neurobiol Dis. 2007 Apr; 26(1):78-85. PMID: 17240155; PMCID: PMC1905496.
      Citations: 4     Fields:    Translation:AnimalsCells
    62. Ruland S, Richardson D, Hung E, Brorson JR, Cruz-Flores S, Felton WL, Ford-Lynch G, Helgason C, Hsu C, Kramer J, Mitsias P, Gorelick PB, AAASPS Investigators. Predictors of recurrent stroke in African Americans. Neurology. 2006 Aug 22; 67(4):567-71. PMID: 16924005.
      Citations: 4     Fields:    Translation:Humans
    63. Li D, Marks JD, Schumacker PT, Young RM, Brorson JR. Physiological hypoxia promotes survival of cultured cortical neurons. Eur J Neurosci. 2005 Sep; 22(6):1319-26. PMID: 16190887.
      Citations: 13     Fields:    Translation:AnimalsCells
    64. Suzuki T, Abe Y, McGehee DS, Keath JR, Yajima H, Sharma K, Brorson JR. Long-lived retrograde fluorescent labeling of corticospinal neurons in the living animal. Brain Res Brain Res Protoc. 2004 Aug; 13(3):183-8. PMID: 15296856.
      Citations: 3     Fields:    Translation:AnimalsCells
    65. Brorson JR, Li D, Suzuki T. Selective expression of heteromeric AMPA receptors driven by flip-flop differences. J Neurosci. 2004 Apr 07; 24(14):3461-70. PMID: 15071093; PMCID: PMC1237000.
      Citations: 23     Fields:    Translation:HumansCells
    66. Hong TE, Thaler D, Brorson J, Heitschmidt M, Hijazi ZM, Amplatzer PFO Investigators. Transcatheter closure of patent foramen ovale associated with paradoxical embolism using the amplatzer PFO occluder: initial and intermediate-term results of the U.S. multicenter clinical trial. Catheter Cardiovasc Interv. 2003 Dec; 60(4):524-8. PMID: 14624434.
      Citations: 7     Fields:    Translation:HumansCTClinical Trials
    67. Du ZD, Cao QL, Joseph A, Koenig P, Heischmidt M, Waight DJ, Rhodes J, Brorson J, Hijazi ZM. Transcatheter closure of patent foramen ovale in patients with paradoxical embolism: intermediate-term risk of recurrent neurological events. Catheter Cardiovasc Interv. 2002 Feb; 55(2):189-94. PMID: 11835645.
      Citations: 3     Fields:    Translation:Humans
    68. Vandenberghe W, Brorson JR. Amyotrophic lateral sclerosis. N Engl J Med. 2001 Oct 11; 345(15):1131-2. PMID: 11596599.
      Citations:    Fields:    Translation:HumansCells
    69. Vandenberghe W, Bindokas VP, Miller RJ, Robberecht W, Brorson JR. Subcellular localization of calcium-permeable AMPA receptors in spinal motoneurons. Eur J Neurosci. 2001 Jul; 14(2):305-14. PMID: 11553281.
      Citations: 5     Fields:    Translation:AnimalsCells
    70. Vandenberghe W, Ihle EC, Patneau DK, Robberecht W, Brorson JR. AMPA receptor current density, not desensitization, predicts selective motoneuron vulnerability. J Neurosci. 2000 Oct 01; 20(19):7158-66. PMID: 11007871; PMCID: PMC6772762.
      Citations: 19     Fields:    Translation:AnimalsCells
    71. Maltepe E, Keith B, Arsham AM, Brorson JR, Simon MC. The role of ARNT2 in tumor angiogenesis and the neural response to hypoxia. Biochem Biophys Res Commun. 2000 Jun 24; 273(1):231-8. PMID: 10873592.
      Citations: 40     Fields:    Translation:AnimalsCells
    72. Vandenberghe W, Robberecht W, Brorson JR. AMPA receptor calcium permeability, GluR2 expression, and selective motoneuron vulnerability. J Neurosci. 2000 Jan 01; 20(1):123-32. PMID: 10627588; PMCID: PMC6774105.
      Citations: 51     Fields:    Translation:AnimalsCells
    73. Brorson JR, Zhang Z, Vandenberghe W. Ca(2+) permeation of AMPA receptors in cerebellar neurons expressing glu receptor 2. J Neurosci. 1999 Nov 01; 19(21):9149-59. PMID: 10531418; PMCID: PMC6782890.
      Citations: 14     Fields:    Translation:AnimalsCells
    74. Brorson JR, Schumacker PT, Zhang H. Nitric oxide acutely inhibits neuronal energy production. The Committees on Neurobiology and Cell Physiology. J Neurosci. 1999 Jan 01; 19(1):147-58. PMID: 9870946; PMCID: PMC6782368.
      Citations: 55     Fields:    Translation:AnimalsCells
    75. Brorson JR, Zhang H. Disrupted [Ca2+]i homeostasis contributes to the toxicity of nitric oxide in cultured hippocampal neurons. J Neurochem. 1997 Nov; 69(5):1882-9. PMID: 9349531.
      Citations: 5     Fields:    Translation:AnimalsCells
    76. Brorson JR, Sulit RA, Zhang H. Nitric oxide disrupts Ca2+ homeostasis in hippocampal neurons. J Neurochem. 1997 Jan; 68(1):95-105. PMID: 8978714.
      Citations: 11     Fields:    Translation:AnimalsCells
    77. Zhang H, Weir B, Marton LS, Macdonald RL, Bindokas V, Miller RJ, Brorson JR. Mechanisms of hemolysate-induced [Ca2+]i elevation in cerebral smooth muscle cells. Am J Physiol. 1995 Dec; 269(6 Pt 2):H1874-90. PMID: 8594895.
      Citations: 3     Fields:    Translation:AnimalsCells
    78. Brorson JR, Marcuccilli CJ, Miller RJ. Delayed antagonism of calpain reduces excitotoxicity in cultured neurons. Stroke. 1995 Jul; 26(7):1259-66; discussion 1267. PMID: 7541574.
      Citations: 19     Fields:    Translation:AnimalsCells
    79. Brorson JR, Manzolillo PA, Gibbons SJ, Miller RJ. AMPA receptor desensitization predicts the selective vulnerability of cerebellar Purkinje cells to excitotoxicity. J Neurosci. 1995 Jun; 15(6):4515-24. PMID: 7540678; PMCID: PMC6577739.
      Citations: 26     Fields:    Translation:AnimalsCells
    80. Foucart S, Gibbons SJ, Brorson JR, Miller RJ. Increase in [Ca2+]i by CCh in adult rat sympathetic neurons are not dependent on intracellular Ca2+ pools. Am J Physiol. 1995 Apr; 268(4 Pt 1):C829-37. PMID: 7733231.
      Citations: 2     Fields:    Translation:AnimalsCells
    81. Brorson JR, Bindokas VP, Iwama T, Marcuccilli CJ, Chisholm JC, Miller RJ. The Ca2+ influx induced by beta-amyloid peptide 25-35 in cultured hippocampal neurons results from network excitation. J Neurobiol. 1995 Mar; 26(3):325-38. PMID: 7775966.
      Citations: 34     Fields:    Translation:AnimalsCells
    82. Holzwarth JA, Gibbons SJ, Brorson JR, Philipson LH, Miller RJ. Glutamate receptor agonists stimulate diverse calcium responses in different types of cultured rat cortical glial cells. J Neurosci. 1994 Apr; 14(4):1879-91. PMID: 8158245; PMCID: PMC6577143.
      Citations: 14     Fields:    Translation:AnimalsCells
    83. Brorson JR, Manzolillo PA, Miller RJ. Ca2+ entry via AMPA/KA receptors and excitotoxicity in cultured cerebellar Purkinje cells. J Neurosci. 1994 Jan; 14(1):187-97. PMID: 7904304; PMCID: PMC6576870.
      Citations: 39     Fields:    Translation:AnimalsCells
    84. Bindokas VP, Brorson JR, Miller RJ. Characteristics of voltage sensitive calcium channels in dendrites of cultured rat cerebellar neurons. Neuropharmacology. 1993 Nov; 32(11):1213-20. PMID: 8107975.
      Citations: 6     Fields:    Translation:AnimalsCells
    85. Gibbons SJ, Brorson JR, Bleakman D, Chard PS, Miller RJ. Calcium influx and neurodegeneration. Ann N Y Acad Sci. 1993 May 28; 679:22-33. PMID: 8390144.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    86. Brorson JR, Bleakman D, Chard PS, Miller RJ. Calcium directly permeates kainate/alpha-amino-3-hydroxy-5-methyl-4- isoxazolepropionic acid receptors in cultured cerebellar Purkinje neurons. Mol Pharmacol. 1992 Apr; 41(4):603-8. PMID: 1373796.
      Citations: 14     Fields:    Translation:AnimalsCells
    87. Brorson JR, Bleakman D, Gibbons SJ, Miller RJ. The properties of intracellular calcium stores in cultured rat cerebellar neurons. J Neurosci. 1991 Dec; 11(12):4024-43. PMID: 1660539; PMCID: PMC6575295.
      Citations: 26     Fields:    Translation:AnimalsCells
    88. Brorson JR. Magnesium suppresses seizurelike discharges in cultured neurons. Arch Neurol. 1991 Jul; 48(7):677-8. PMID: 1830469.
      Citations:    Fields:    Translation:HumansCells
    89. Bleakman D, Brorson JR, Miller RJ. The effect of capsaicin on voltage-gated calcium currents and calcium signals in cultured dorsal root ganglion cells. Br J Pharmacol. 1990 Oct; 101(2):423-31. PMID: 1701680; PMCID: PMC1917715.
      Citations: 20     Fields:    Translation:AnimalsCells
    90. Brorson JR, Novak ES, Makinen MW. Solvent structure and enzyme activity. J Biomol Struct Dyn. 1985 Aug; 3(1):197-204. PMID: 3917015.
      Citations:    Fields:    Translation:Cells
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