"Complement C5" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
C5 plays a central role in both the classical and the alternative pathway of COMPLEMENT ACTIVATION. C5 is cleaved by C5 CONVERTASE into COMPLEMENT C5A and COMPLEMENT C5B. The smaller fragment C5a is an ANAPHYLATOXIN and mediator of inflammatory process. The major fragment C5b binds to the membrane initiating the spontaneous assembly of the late complement components, C5-C9, into the MEMBRANE ATTACK COMPLEX.
| Descriptor ID |
D003182
|
| MeSH Number(s) |
D12.776.124.486.274.450
|
| Concept/Terms |
Complement C5- Complement C5
- C5, Complement
- C5 Complement
- Complement, C5
- Complement 5
- Complement Component 5
- Component 5, Complement
Complement C5, Precursor- Complement C5, Precursor
- C5, Precursor Complement
- Precursor Complement C5
- Pro-C5
- Pro C5
- Pro-complement 5
- Pro complement 5
- Precursor C5
- C5, Precursor
|
Below are MeSH descriptors whose meaning is more general than "Complement C5".
Below are MeSH descriptors whose meaning is more specific than "Complement C5".
This graph shows the total number of publications written about "Complement C5" by people in this website by year, and whether "Complement C5" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 1 | 1 |
| 2007 | 1 | 0 | 1 |
| 2011 | 1 | 0 | 1 |
| 2012 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
| 2020 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Complement C5" by people in Profiles.
-
Immunoglobulin-driven Complement Activation Regulates Proinflammatory Remodeling in Pulmonary Hypertension. Am J Respir Crit Care Med. 2020 01 15; 201(2):224-239.
-
Structural basis for therapeutic inhibition of complement C5. Nat Struct Mol Biol. 2016 05; 23(5):378-86.
-
Unilateral uterine ischemia/reperfusion-induced bilateral fetal loss and fetal growth restriction in a murine model require intact complement component 5. J Reprod Immunol. 2012 Sep; 95(1-2):27-35.
-
Distinct roles for C3a and C5a in complement-induced tubulointerstitial injury. Kidney Int. 2011 Sep; 80(5):524-34.
-
The many effects of complement C3- and C5-binding proteins in renal injury. Semin Nephrol. 2007 May; 27(3):321-37.
-
Glomerular complement regulation is overwhelmed in passive Heymann nephritis. Kidney Int. 2001 Sep; 60(3):900-9.
-
[C5 contents and neutrophil chemotactic activities in bronchiolar and alveolar regions]. Nihon Kyobu Shikkan Gakkai Zasshi. 1991 Jun; 29(6):677-84.
-
A properdin dependent nephritic factor slowly activating C3, C5, and C9 in membranoproliferative glomerulonephritis, types I and III. Clin Immunol Immunopathol. 1989 Mar; 50(3):333-47.
-
Serum terminal complement component levels in hypocomplementemic glomerulonephritides. Clin Immunol Immunopathol. 1989 Mar; 50(3):307-20.
-
Tumor necrosis factor/cachectin. Induction of hemorrhagic necrosis in normal tissue requires the fifth component of complement (C5). J Exp Med. 1988 Dec 01; 168(6):2007-21.