"Properdin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 53-kDa protein that is a positive regulator of the alternate pathway of complement activation (COMPLEMENT ACTIVATION PATHWAY, ALTERNATIVE). It stabilizes the ALTERNATIVE PATHWAY C3 CONVERTASE (C3bBb) and protects it from rapid inactivation, thus facilitating the cascade of COMPLEMENT ACTIVATION and the formation of MEMBRANE ATTACK COMPLEX. Individuals with mutation in the PFC gene exhibit properdin deficiency and have a high susceptibility to infections.
| Descriptor ID |
D011414
|
| MeSH Number(s) |
D12.776.124.486.274.965 D12.776.124.790.223.624 D12.776.377.715.182.624
|
| Concept/Terms |
Properdin- Properdin
- Complement Factor P
- Factor P, Complement
|
Below are MeSH descriptors whose meaning is more general than "Properdin".
Below are MeSH descriptors whose meaning is more specific than "Properdin".
This graph shows the total number of publications written about "Properdin" by people in this website by year, and whether "Properdin" was a major or minor topic of these publications.
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Below are the most recent publications written about "Properdin" by people in Profiles.
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Genetic and physical mapping around the properdin P gene. Genomics. 1991 Dec; 11(4):991-6.
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A properdin dependent nephritic factor slowly activating C3, C5, and C9 in membranoproliferative glomerulonephritis, types I and III. Clin Immunol Immunopathol. 1989 Mar; 50(3):333-47.