"Complement C3" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A glycoprotein that is central in both the classical and the alternative pathway of COMPLEMENT ACTIVATION. C3 can be cleaved into COMPLEMENT C3A and COMPLEMENT C3B, spontaneously at low level or by C3 CONVERTASE at high level. The smaller fragment C3a is an ANAPHYLATOXIN and mediator of local inflammatory process. The larger fragment C3b binds with C3 convertase to form C5 convertase.
| Descriptor ID |
D003176
|
| MeSH Number(s) |
D12.776.124.050.140 D12.776.124.486.274.250
|
| Concept/Terms |
Complement C3- Complement C3
- C3, Complement
- Complement 3
- Complement Component 3
- Component 3, Complement
- C3 Complement
- Complement, C3
Complement C3 Precursor- Complement C3 Precursor
- C3 Precursor, Complement
- Precursor, Complement C3
- Pro-C3
- Pro C3
- Precursor-Complement 3
- Precursor Complement 3
- Pro-Complement 3
- Pro Complement 3
- C3 Precursor
- Precursor, C3
|
Below are MeSH descriptors whose meaning is more general than "Complement C3".
Below are MeSH descriptors whose meaning is more specific than "Complement C3".
This graph shows the total number of publications written about "Complement C3" by people in this website by year, and whether "Complement C3" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 2 | 2 |
| 1997 | 2 | 2 | 4 |
| 1998 | 1 | 0 | 1 |
| 2000 | 1 | 1 | 2 |
| 2001 | 0 | 2 | 2 |
| 2002 | 1 | 1 | 2 |
| 2003 | 1 | 0 | 1 |
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2007 | 2 | 5 | 7 |
| 2009 | 1 | 0 | 1 |
| 2010 | 1 | 1 | 2 |
| 2011 | 1 | 0 | 1 |
| 2012 | 1 | 1 | 2 |
| 2013 | 2 | 0 | 2 |
| 2015 | 0 | 1 | 1 |
| 2018 | 1 | 0 | 1 |
| 2019 | 0 | 1 | 1 |
| 2020 | 0 | 2 | 2 |
| 2025 | 0 | 1 | 1 |
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click here.
Below are the most recent publications written about "Complement C3" by people in Profiles.
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Targeting C1q prevents microglia-mediated synaptic removal in neuropathic pain. Nat Commun. 2025 May 17; 16(1):4590.
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Absence of complement factor H reduces physical performance in C57BL6 mice. Immunobiology. 2020 09; 225(5):152003.
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Immunoglobulin-driven Complement Activation Regulates Proinflammatory Remodeling in Pulmonary Hypertension. Am J Respir Crit Care Med. 2020 01 15; 201(2):224-239.
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Mature neutrophils suppress T cell immunity in ovarian cancer microenvironment. JCI Insight. 2019 03 07; 4(5).
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Taming hemodialysis-induced inflammation: Are complement C3 inhibitors a viable option? Clin Immunol. 2019 01; 198:102-105.
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An athletic adolescent girl with proteinuria and hypertension. Pediatr Ann. 2015 Mar; 44(3):e58-61.
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Hepatic nuclear factor 4a positively regulates complement C3 expression and does not interfere with TNFa-mediated stimulation of C3 expression in HepG2 cells. Gene. 2013 Jul 25; 524(2):187-92.
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Complement mediated signaling on pulmonary CD103(+) dendritic cells is critical for their migratory function in response to influenza infection. PLoS Pathog. 2013 Jan; 9(1):e1003115.
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The role of complement component 3 (C3) in differentiation of myeloid-derived suppressor cells. Blood. 2013 Mar 07; 121(10):1760-8.
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Peroxisome proliferator-activated receptor a positively regulates complement C3 expression but inhibits tumor necrosis factor a-mediated activation of C3 gene in mammalian hepatic-derived cells. J Biol Chem. 2013 Jan 18; 288(3):1726-38.