A synthetic-lethality RNAi screen reveals an ERK-mTOR co-targeting pro-apoptotic switch in PIK3CA+ oral cancers.

A synthetic-lethality RNAi screen reveals an ERK-mTOR co-targeting pro-apoptotic switch in PIK3CA+ oral cancers. Oncotarget. 2016 Mar 08; 7(10):10696-709.

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subject areas

Animals
Antineoplastic Combined Chemotherapy Protocols
Apoptosis
Cell Line, Tumor
Class I Phosphatidylinositol 3-Kinases
Drug Synergism
Female
Heterografts
Humans
MAP Kinase Signaling System
Mice
Mice, Nude
Molecular Targeted Therapy
Mouth Neoplasms
Pyridones
Pyrimidinones
RNA Interference
Sirolimus
TOR Serine-Threonine Kinases

authors with profiles

Ezra Cohen