"RNA Interference" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A gene silencing phenomenon whereby specific dsRNAs (RNA, DOUBLE-STRANDED) trigger the degradation of homologous mRNA (RNA, MESSENGER). The specific dsRNAs are processed into SMALL INTERFERING RNA (siRNA) which serves as a guide for cleavage of the homologous mRNA in the RNA-INDUCED SILENCING COMPLEX. DNA METHYLATION may also be triggered during this process.
| Descriptor ID |
D034622
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| MeSH Number(s) |
G05.308.203.374.790
|
| Concept/Terms |
RNA Interference- RNA Interference
- Interference, RNA
- Gene Silencing, Post-Transcriptional
- Gene Silencing, Post Transcriptional
- RNA Silencing
- Post-Transcriptional Gene Silencing
- Post Transcriptional Gene Silencing
- Post-Transcriptional Gene Silencings
- Silencing, Post-Transcriptional Gene
- RNAi
- Posttranscriptional Gene Silencing
- Gene Silencing, Posttranscriptional
- Gene Silencings, Posttranscriptional
|
Below are MeSH descriptors whose meaning is more general than "RNA Interference".
Below are MeSH descriptors whose meaning is more specific than "RNA Interference".
This graph shows the total number of publications written about "RNA Interference" by people in this website by year, and whether "RNA Interference" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2003 | 3 | 0 | 3 |
| 2004 | 3 | 6 | 9 |
| 2005 | 4 | 9 | 13 |
| 2006 | 3 | 9 | 12 |
| 2007 | 4 | 14 | 18 |
| 2008 | 0 | 13 | 13 |
| 2009 | 3 | 13 | 16 |
| 2010 | 3 | 20 | 23 |
| 2011 | 1 | 17 | 18 |
| 2012 | 1 | 20 | 21 |
| 2013 | 1 | 19 | 20 |
| 2014 | 3 | 21 | 24 |
| 2015 | 0 | 25 | 25 |
| 2016 | 1 | 12 | 13 |
| 2017 | 1 | 20 | 21 |
| 2018 | 1 | 9 | 10 |
| 2019 | 2 | 6 | 8 |
| 2020 | 0 | 2 | 2 |
| 2021 | 0 | 7 | 7 |
| 2024 | 0 | 1 | 1 |
| 2026 | 0 | 2 | 2 |
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Below are the most recent publications written about "RNA Interference" by people in Profiles.
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Analysis of the impact of gene evolution on reproductive effects reveals prevalent sexual and germline-soma conflicts. Nat Ecol Evol. 2026 Jun; 10(6):1155-1167.
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RoboA reinforces planarian stem cell fate through FoxA and Anosmin1a. Nat Commun. 2026 Jan 23; 17(1).
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RNA Interference With Zilebesiran for Mild to Moderate Hypertension: The KARDIA-1 Randomized Clinical Trial. JAMA. 2024 03 05; 331(9):740-749.
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Death Induced by Survival gene Elimination (DISE) correlates with neurotoxicity in Alzheimer's disease and aging. Nat Commun. 2024 01 18; 15(1):264.
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Zilebesiran for Hypertension. Reply. N Engl J Med. 2023 10 12; 389(15):1439-1440.
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Zilebesiran, an RNA Interference Therapeutic Agent for Hypertension. N Engl J Med. 2023 07 20; 389(3):228-238.
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Human miRNA miR-675 inhibits DUX4 expression and may be exploited as a potential treatment for Facioscapulohumeral muscular dystrophy. Nat Commun. 2021 12 08; 12(1):7128.
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Autocrine signaling by receptor tyrosine kinases in urothelial carcinoma of the bladder. PLoS One. 2021; 16(7):e0241766.
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Programmable technologies to manipulate gene expression at the RNA level. Curr Opin Chem Biol. 2021 10; 64:27-37.
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Hypoxia Preconditioning Promotes the Proliferation and Migration of Human Urine-Derived Stem Cells in Chronically Injured Liver of Mice by Upregulating CXCR4. Stem Cells Dev. 2021 05 15; 30(10):526-536.