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Juan Mendoza

TitleAssistant Professor
InstitutionUniversity of Chicago
DepartmentPritzker Institute for Molecular Engineering
AddressChicago IL 60637
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    Collapse Overview 
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    Collapse Biography 
    Collapse education and training
    Stanford University, Stanford, CAPost-doc11/2018Structural biology, Immunology
    University of Texas Southwestern Medical Center at Dallas, Dallas, TXPh.D.11/2011Molecular biophysics w/ emphasis in computational and systems biology
    San Francisco State University, San Francisco, CAB.S.11/2003Biochemistry
    Collapse awards and honors
    2013 - 2018Career Development Award (K01), NIH, NCI
    2013Fellowship, Helen Hay Whitney Foundation
    2012Fellowship, Damon Runyon Cancer Research Foundation
    2011Dean’s Discretionary Award – Academic and Research Excellence, UTSW
    2011Best Graduate Student Poster, Molecular Biophysics Annual Symposium, UTSW
    2004 - 2005Fellowship, Louis Stokes Alliance for Minority Participation, NSF
    2004Edwin Motel Award – Most Promising Student, SFSU
    2003 - 2004Post-Baccalaureate Research Education Program, NIH

    Collapse Research 
    Collapse research activities and funding
    R35GM147179     (MENDOZA, JUAN LUIS)Jul 1, 2022 - Apr 30, 2027
    NIH
    Shedding new light on cytokine signaling through molecular engineering
    Role: Principal Investigator
    K01CA175127     (MENDOZA, JUAN LUIS)Sep 18, 2013 - Oct 31, 2018
    NIH
    Diversifying interferon functions through combinatorial and structural biology
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Grubbe WS, Zhang B, Kauffman A, Byléhn F, Padol K, Jung HG, Park SB, Priest JM, Özkan E, de Pablo JJ, Liang TJ, Zhao M, Mendoza JL. Structural studies of the IFN?4 receptor complex using cryoEM enabled by protein engineering. Nat Commun. 2025 Jan 18; 16(1):818. PMID: 39827213; PMCID: PMC11742915.
      Citations:    Fields:    Translation:HumansCells
    2. Priest JM, Nichols EL, Smock RG, Hopkins JB, Mendoza JL, Meijers R, Shen K, Özkan E. Structural insights into the formation of repulsive netrin guidance complexes. Sci Adv. 2024 Feb 16; 10(7):eadj8083. PMID: 38363837; PMCID: PMC10871540.
      Citations:    Fields:    Translation:AnimalsCells
    3. Grubbe WS, Byléhn F, Alvarado W, de Pablo JJ, Mendoza JL. Molecular analysis of the type III interferon complex and its applications in protein engineering. Biophys J. 2023 11 07; 122(21):4254-4263. PMID: 37794680; PMCID: PMC10645568.
      Citations: 1     Fields:    Translation:Cells
    4. Aung T, Grubbe WS, Nusbaum RJ, Mendoza JL. Recent and future perspectives on engineering interferons and other cytokines as therapeutics. Trends Biochem Sci. 2023 03; 48(3):259-273. PMID: 36241490; PMCID: PMC9974544.
      Citations: 7     Fields:    
    5. Mansurov A, Hosseinchi P, Chang K, Lauterbach AL, Gray LT, Alpar AT, Budina E, Slezak AJ, Kang S, Cao S, Solanki A, Gomes S, Williford JM, Swartz MA, Mendoza JL, Ishihara J, Hubbell JA. Masking the immunotoxicity of interleukin-12 by fusing it with a domain of its receptor via a tumour-protease-cleavable linker. Nat Biomed Eng. 2022 07; 6(7):819-829. PMID: 35534574; PMCID: PMC11155269.
      Citations: 24     Fields:    Translation:Animals
    6. Gee MH, Han A, Lofgren SM, Beausang JF, Mendoza JL, Birnbaum ME, Bethune MT, Fischer S, Yang X, Gomez-Eerland R, Bingham DB, Sibener LV, Fernandes RA, Velasco A, Baltimore D, Schumacher TN, Khatri P, Quake SR, Davis MM, Garcia KC. Antigen Identification for Orphan T Cell Receptors Expressed on Tumor-Infiltrating Lymphocytes. Cell. 2018 01 25; 172(3):549-563.e16. PMID: 29275860; PMCID: PMC5786495.
      Citations: 149     Fields:    Translation:HumansAnimalsCells
    7. Moraga I, Spangler JB, Mendoza JL, Gakovic M, Wehrman TS, Krutzik P, Garcia KC. Synthekines are surrogate cytokine and growth factor agonists that compel signaling through non-natural receptor dimers. Elife. 2017 05 12; 6. PMID: 28498099; PMCID: PMC5429090.
      Citations: 36     Fields:    Translation:HumansCells
    8. Mendoza JL, Schneider WM, Hoffmann HH, Vercauteren K, Jude KM, Xiong A, Moraga I, Horton TM, Glenn JS, de Jong YP, Rice CM, Garcia KC. The IFN-?-IFN-?R1-IL-10Rß Complex Reveals Structural Features Underlying Type III IFN Functional Plasticity. Immunity. 2017 03 21; 46(3):379-392. PMID: 28329704; PMCID: PMC5510750.
      Citations: 58     Fields:    Translation:HumansAnimalsCells
    9. Birnbaum ME, Mendoza JL, Sethi DK, Dong S, Glanville J, Dobbins J, Ozkan E, Davis MM, Wucherpfennig KW, Garcia KC. Deconstructing the peptide-MHC specificity of T cell recognition. Cell. 2014 May 22; 157(5):1073-87. PMID: 24855945; PMCID: PMC4071348.
      Citations: 297     Fields:    Translation:HumansAnimalsCells
    10. Mendoza JL, Li Q, Nuvaga E, Barrett T, Bridges RJ, Feranchak AP, Brautigam CA, Thomas PJ, Schmidt A. Requirements for efficient correction of ?F508 CFTR revealed by analyses of evolved sequences. Cell. 2012 Jan 20; 148(1-2):164-74. PMID: 22265409; PMCID: PMC3266553.
      Citations: 153     Fields:    Translation:HumansAnimalsCells
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