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Bryan Dickinson

TitleProfessor
InstitutionUniversity of Chicago
DepartmentChemistry
AddressChicago IL 60637
Email
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    Collapse Research 
    Collapse research activities and funding
    R13CA290754     (DICKINSON, BRYAN)Jul 1, 2024 - Jun 30, 2025
    NIH
    Protein Lipidation: Enzymology, Signaling, Therapeutics
    Role: Principal Investigator
    R01EB035016     (DICKINSON, BRYAN)Jun 1, 2023 - May 31, 2027
    NIH
    Engineering human-derived programmable RNA effectors to retune gene expression
    Role: Principal Investigator
    R01MH122142     (DICKINSON, BRYAN)Sep 25, 2019 - Jul 31, 2024
    NIH
    Base-resolution mapping and site-specific epitranscriptomic studies in the brain
    Role: Principal Investigator
    RF1MH114102     (DICKINSON, BRYAN)Aug 3, 2017 - Aug 2, 2021
    NIH
    Split RNA polymerases for sensitive, multidimensional analysis of intercellular PPIs at synapses
    Role: Principal Investigator
    R21CA217754     (DICKINSON, BRYAN)Aug 3, 2017 - Jul 31, 2021
    NIH
    rePPI-i: A system for the rapid continuous evolution of protein-protein interaction inhibitors
    Role: Principal Investigator
    R35GM119840     (DICKINSON, BRYAN)Jul 15, 2016 - May 31, 2026
    NIH
    Chemical biology approaches to probe signaling by protein lipidation
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Gopal K, Azizi SA, Lan T, Sorop O, Heinonen IHA, Schianchi F, Luiken JJFP, Aksentijevic D, Dickinson BC, Ussher JR, Fuller W, Dennis KMJH, Montes Aparicio CN, Zhang JA, Castro-Guarda M, Nicol T, Devereux RM, Carter RD, Purnama U, Carr CA, Simsek G, Gill EK, Swietach P, Duncker DJ, De Val S, Heather LC. FoxO1-zDHHC4-CD36 S-Acylation Axis Drives Metabolic Dysfunction in Diabetes. Circ Res. 2025 Jun 06; 136(12):1545-1560. PMID: 40357580; PMCID: PMC12136392.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    2. Dickinson BC. Introduction: Synthetic Biology. Chem Rev. 2025 Mar 26; 125(6):3005-3006. PMID: 40134283.
      Citations:    Fields:    
    3. Qiu T, Azizi SA, Pani S, Dickinson BC. Dynamic PRDX S-acylation modulates ROS stress and signaling. Cell Chem Biol. 2025 Mar 20; 32(3):511-519.e5. PMID: 40010334; PMCID: PMC11928249.
      Citations:    Fields:    Translation:HumansCells
    4. Styles MJ, Pixley JA, Wei T, Basile C, Lu SS, Dickinson BC. High-throughput protein binder discovery by rapid in vivo selection. bioRxiv. 2025 Jan 17. PMID: 39829796; PMCID: PMC11741316.
      Citations:    
    5. Lan T, Peng C, Yao X, Chan RST, Wei T, Rupanya A, Radakovic A, Wang S, Chen S, Lovell S, Snyder SA, Bogyo M, Dickinson BC. Discovery of Thioether-Cyclized Macrocyclic Covalent Inhibitors by mRNA Display. J Am Chem Soc. 2024 Aug 28; 146(34):24053-24060. PMID: 39136646; PMCID: PMC11837906.
      Citations: 5     Fields:    Translation:Cells
    6. Liu Z, Li S, Wang C, Vidmar KJ, Bracey S, Li L, Willard B, Miyagi M, Lan T, Dickinson BC, Osme A, Pizarro TT, Xiao TS. Palmitoylation at a conserved cysteine residue facilitates gasdermin D-mediated pyroptosis and cytokine release. Proc Natl Acad Sci U S A. 2024 Jul 16; 121(29):e2400883121. PMID: 38980908; PMCID: PMC11260154.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    7. Lan T, Slezak T, Pu J, Zinkus-Boltz J, Adhikari S, Pekow JR, Taneja V, Zuniga J, Gómez-García IA, Regino-Zamarripa N, Ahmed M, Khader SA, Rubin DT, Kossiakoff AA, Dickinson BC. Development of Luminescent Biosensors for Calprotectin. ACS Chem Biol. 2024 06 21; 19(6):1250-1259. PMID: 38843544; PMCID: PMC12072359.
      Citations: 3     Fields:    Translation:Humans
    8. Lan T, Dickinson BC. Bump-hole ZDHHCs. Nat Chem Biol. 2024 Jun; 20(6):666-667. PMID: 38806775.
      Citations:    Fields:    
    9. Di M, Lv J, Jing Z, Yang Y, Yan K, Wu J, Ge J, Rauch S, Dickinson BC, Chi T. Expanding RNA editing toolkit using an IDR-based strategy. Mol Ther Nucleic Acids. 2024 Jun 11; 35(2):102190. PMID: 38721279; PMCID: PMC11077028.
      Citations: 1     
    10. Pani S, Qiu T, Kentala K, Azizi SA, Dickinson BC. Bioorthogonal masked acylating agents for proximity-dependent RNA labelling. Nat Chem. 2024 May; 16(5):717-726. PMID: 38594368; PMCID: PMC11613155.
      Citations: 9     Fields:    Translation:HumansCells
    11. S Mesquita F, Abrami L, Linder ME, Bamji SX, Dickinson BC, van der Goot FG. Mechanisms and functions of protein S-acylation. Nat Rev Mol Cell Biol. 2024 Jun; 25(6):488-509. PMID: 38355760; PMCID: PMC12010433.
      Citations: 47     Fields:    Translation:HumansAnimalsCells
    12. Liau WS, Zhao Q, Bademosi A, Gormal RS, Gong H, Marshall PR, Periyakaruppiah A, Madugalle SU, Zajaczkowski EL, Leighton LJ, Ren H, Musgrove M, Davies J, Rauch S, He C, Dickinson BC, Li X, Wei W, Meunier FA, Fernández-Moya SM, Kiebler MA, Srinivasan B, Banerjee S, Clark M, Spitale RC, Bredy TW. Fear extinction is regulated by the activity of long noncoding RNAs at the synapse. Nat Commun. 2023 11 22; 14(1):7616. PMID: 37993455; PMCID: PMC10665438.
      Citations: 12     Fields:    Translation:AnimalsCells
    13. Cao Y, Liu H, Lu SS, Jones KA, Govind AP, Jeyifous O, Simmons CQ, Tabatabaei N, Green WN, Holder JL, Tahmasebi S, George AL, Dickinson BC. RNA-based translation activators for targeted gene upregulation. Nat Commun. 2023 10 26; 14(1):6827. PMID: 37884512; PMCID: PMC10603104.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    14. Azizi SA, Qiu T, Brookes NE, Dickinson BC. Regulation of ERK2 activity by dynamic S-acylation. Cell Rep. 2023 09 26; 42(9):113135. PMID: 37715953; PMCID: PMC10591828.
      Citations: 6     Fields:    Translation:AnimalsCells
    15. Madugalle SU, Liau WS, Zhao Q, Li X, Gong H, Marshall PR, Periyakaruppiah A, Zajaczkowski EL, Leighton LJ, Ren H, Musgrove MRB, Davies JWA, Kim G, Rauch S, He C, Dickinson BC, Fulopova B, Fletcher LN, Williams SR, Spitale RC, Bredy TW. Synapse-Enriched m6A-Modified Malat1 Interacts with the Novel m6A Reader, DPYSL2, and Is Required for Fear-Extinction Memory. J Neurosci. 2023 10 25; 43(43):7084-7100. PMID: 37669863; PMCID: PMC10601377.
      Citations: 11     Fields:    Translation:AnimalsCells
    16. Chen L, Zhang LS, Ye C, Zhou H, Liu B, Gao B, Deng Z, Zhao C, He C, Dickinson BC. Nm-Mut-seq: a base-resolution quantitative method for mapping transcriptome-wide 2'-O-methylation. Cell Res. 2023 09; 33(9):727-730. PMID: 37316584; PMCID: PMC10474006.
      Citations: 14     Fields:    Translation:HumansCells
    17. Azad T, Rezaei R, Singaravelu R, Pelin A, Boulton S, Petryk J, Onsu KA, Martin NT, Hoskin V, Ghahremani M, Marotel M, Marius R, He X, Crupi MJF, Hoang HD, Nik-Akhtar A, Ahmadi M, Zamani NK, Golshani A, Alain T, Greer P, Ardolino M, Dickinson BC, Tai LH, Ilkow CS, Bell JC. Synthetic virology approaches to improve the safety and efficacy of oncolytic virus therapies. Nat Commun. 2023 05 26; 14(1):3035. PMID: 37236967; PMCID: PMC10213590.
      Citations: 18     Fields:    Translation:Cells
    18. Wolf E, Lento C, Pu J, Dickinson BC, Wilson DJ. Innate Conformational Dynamics Drive Binding Specificity in Anti-Apoptotic Proteins Mcl-1 and Bcl-2. Biochemistry. 2023 06 06; 62(11):1619-1630. PMID: 37192192; PMCID: PMC10249625.
      Citations: 5     Fields:    Translation:Cells
    19. Martin NT, Crupi MJF, Taha Z, Poutou J, Whelan JT, Vallati S, Petryk J, Marius R, Austin B, Azad T, Boulanger M, Burgess T, Sanders I, Victoor C, Dickinson BC, Diallo JS, Ilkow CS, Bell JC. Engineering Rapalog-Inducible Genetic Switches Based on Split-T7 Polymerase to Regulate Oncolytic Virus-Driven Production of Tumour-Localized IL-12 for Anti-Cancer Immunotherapy. Pharmaceuticals (Basel). 2023 May 07; 16(5). PMID: 37242495; PMCID: PMC10224353.
      Citations: 4     
    20. Abazari D, Wild AR, Qiu T, Dickinson BC, Bamji SX. Activity-dependent post-translational regulation of palmitoylating and depalmitoylating enzymes in the hippocampus. J Cell Sci. 2023 04 01; 136(7). PMID: 37039765; PMCID: PMC10113885.
      Citations: 10     Fields:    Translation:AnimalsCells
    21. Dong G, Adak S, Spyropoulos G, Zhang Q, Feng C, Yin L, Speck SL, Shyr Z, Morikawa S, Kitamura RA, Kathayat RS, Dickinson BC, Ng XW, Piston DW, Urano F, Remedi MS, Wei X, Semenkovich CF. Palmitoylation couples insulin hypersecretion with ß cell failure in diabetes. Cell Metab. 2023 02 07; 35(2):332-344.e7. PMID: 36634673; PMCID: PMC9908855.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    22. Brown RWB, Sharma AI, Villanueva MR, Li X, Onguka O, Zilbermintz L, Nguyen H, Falk BA, Olson CL, Taylor JM, Epting CL, Kathayat RS, Amara N, Dickinson BC, Bogyo M, Engman DM. Trypanosoma brucei Acyl-Protein Thioesterase-like (TbAPT-L) Is a Lipase with Esterase Activity for Short and Medium-Chain Fatty Acids but Has No Depalmitoylation Activity. Pathogens. 2022 Oct 27; 11(11). PMID: 36364996; PMCID: PMC9693859.
      Citations:    Fields:    
    23. Azizi SA, Lan T, Qiu T, Dickinson BC, Delalande C. Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Oct 13; 13(10):1648-1654. PMID: 36262404; PMCID: PMC9575173.
      Citations: 5     
    24. Qiu T, Azizi SA, Brookes N, Lan T, Dickinson BC. A High-Throughput Fluorescent Turn-On Assay for Inhibitors of DHHC Family Proteins. ACS Chem Biol. 2022 08 19; 17(8):2018-2023. PMID: 35816339; PMCID: PMC9391280.
      Citations: 6     Fields:    Translation:Cells
    25. Liu H, Zeng T, He C, Rawal VH, Zhou H, Dickinson BC. Development of Mild Chemical Catalysis Conditions for m1A-to-m6A Rearrangement on RNA. ACS Chem Biol. 2022 06 17; 17(6):1334-1342. PMID: 35593877; PMCID: PMC9238441.
      Citations: 9     Fields:    Translation:HumansCells
    26. Shafik AM, Zhou H, Lim J, Dickinson B, Jin P. Dysregulated mitochondrial and cytosolic tRNA m1A methylation in Alzheimer's disease. Hum Mol Genet. 2022 05 19; 31(10):1673-1680. PMID: 34897434; PMCID: PMC9122638.
      Citations: 37     Fields:    Translation:AnimalsCells
    27. Xie VC, Styles MJ, Dickinson BC. Methods for the directed evolution of biomolecular interactions. Trends Biochem Sci. 2022 05; 47(5):403-416. PMID: 35427479; PMCID: PMC9022280.
      Citations: 4     Fields:    
    28. Qiu T, Kathayat RS, Dickinson BC, Luebben AV, Bender D, Becker S, Crowther LM, Erven I, Hofmann K, Söding J, Klemp H, Bellotti C, Stäuble A, Gärtner J, Sheldrick GM, Krätzner R, Steinfeld R. Cln5 represents a new type of cysteine-based S-depalmitoylase linked to neurodegeneration. Sci Adv. 2022 04 15; 8(15):eabj8633. PMID: 35427157; PMCID: PMC9012467.
      Citations: 8     Fields:    Translation:Humans
    29. Krohannon A, Srivastava M, Rauch S, Srivastava R, Dickinson BC, Janga SC. CASowary: CRISPR-Cas13 guide RNA predictor for transcript depletion. BMC Genomics. 2022 Mar 02; 23(1):172. PMID: 35236300; PMCID: PMC8889671.
      Citations: 6     Fields:    Translation:HumansCells
    30. Nguyen LC, Yang D, Nicolaescu V, Best TJ, Gula H, Saxena D, Gabbard JD, Chen SN, Ohtsuki T, Friesen JB, Drayman N, Mohamed A, Dann C, Silva D, Robinson-Mailman L, Valdespino A, Jones KA, Azizi SA, Demarco JK, Severson WE, Anderson CD, Millis JM, Dickinson BC, Tay S, Oakes SA, Pauli GF, Palmer KE, National COVID Cohort Collaborative Consortium, Meltzer DO, Randall G, Rosner MR, Stock L, Suárez E. Cannabidiol inhibits SARS-CoV-2 replication through induction of the host ER stress and innate immune responses. Sci Adv. 2022 Feb 25; 8(8):eabi6110. PMID: 35050692; PMCID: PMC11816653.
      Citations: 65     Fields:    Translation:HumansAnimalsCells
    31. Dickinson BC, Shoulders M. Editorial Overview: Molecular synthetic biology: from understanding life to creating smart therapeutics. Curr Opin Chem Biol. 2021 10; 64:A1-A2. PMID: 34649774.
      Citations:    Fields:    
    32. Jones KA, Snodgrass HM, Belsare K, Dickinson BC, Lewis JC. Phage-Assisted Continuous Evolution and Selection of Enzymes for Chemical Synthesis. ACS Cent Sci. 2021 Sep 22; 7(9):1581-1590. PMID: 34584960; PMCID: PMC8461764.
      Citations: 11     
    33. Gupta Y, Kumar S, Zak SE, Jones KA, Upadhyay C, Sharma N, Azizi SA, Kathayat RS, Herbert AS, Durvasula R, Dickinson BC, Dye JM, Rathi B, Kempaiah P. Antiviral evaluation of hydroxyethylamine analogs: Inhibitors of SARS-CoV-2 main protease (3CLpro), a virtual screening and simulation approach. Bioorg Med Chem. 2021 10 01; 47:116393. PMID: 34509862; PMCID: PMC8416325.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    34. Lan T, Dickinson BC, Delalande C. Inhibitors of DHHC family proteins. Curr Opin Chem Biol. 2021 12; 65:118-125. PMID: 34467875; PMCID: PMC8671176.
      Citations: 37     Fields:    Translation:Cells
    35. Qiu T, Dickinson BC. A stop sign for RAS trafficking. Nat Chem Biol. 2021 08; 17(8):840-841. PMID: 33927410.
      Citations:    Fields:    Translation:Cells
    36. Dewey JA, Azizi SA, Lu V, Dickinson BC. A System for the Evolution of Protein-Protein Interaction Inducers. ACS Synth Biol. 2021 08 20; 10(8):2096-2110. PMID: 34319091; PMCID: PMC8590884.
      Citations: 5     Fields:    Translation:Cells
    37. Azizi SA, Lan T, Kathayat RS, Banales Mejia F, Qin A, Brookes N, Sandoval PJ, Dickinson BC, Delalande C. Development of an Acrylamide-Based Inhibitor of Protein S-Acylation. ACS Chem Biol. 2021 08 20; 16(8):1546-1556. PMID: 34309372; PMCID: PMC8590885.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    38. Drayman N, DeMarco JK, Jones KA, Azizi SA, Froggatt HM, Tan K, Maltseva NI, Chen S, Nicolaescu V, Dvorkin S, Furlong K, Kathayat RS, Firpo MR, Mastrodomenico V, Bruce EA, Schmidt MM, Jedrzejczak R, Schuster B, Nair V, Han KY, O'Brien A, Tomatsidou A, Meyer B, Vignuzzi M, Missiakas D, Botten JW, Brooke CB, Lee H, Baker SC, Mounce BC, Heaton NS, Severson WE, Palmer KE, Dickinson BC, Joachimiak A, Randall G, Tay S, Muñoz-Alía MÁ. Masitinib is a broad coronavirus 3CL inhibitor that blocks replication of SARS-CoV-2. Science. 2021 08 20; 373(6557):931-936. PMID: 34285133; PMCID: PMC8809056.
      Citations: 134     Fields:    Translation:HumansAnimalsCells
    39. Xie VC, Pu J, Metzger BP, Thornton JW, Dickinson BC. Contingency and chance erase necessity in the experimental evolution of ancestral proteins. Elife. 2021 06 01; 10. PMID: 34061027; PMCID: PMC8282340.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    40. Liu H, Rauch S, Dickinson BC. Programmable technologies to manipulate gene expression at the RNA level. Curr Opin Chem Biol. 2021 10; 64:27-37. PMID: 33930627; PMCID: PMC8548394.
      Citations: 1     Fields:    
    41. Nguyen LC, Yang D, Nicolaescu V, Best TJ, Ohtsuki T, Chen SN, Friesen JB, Drayman N, Mohamed A, Dann C, Silva D, Gula H, Jones KA, Millis JM, Dickinson BC, Tay S, Oakes SA, Pauli GF, Meltzer DO, Randall G, Rosner MR. Cannabidiol Inhibits SARS-CoV-2 Replication and Promotes the Host Innate Immune Response. bioRxiv. 2021 Mar 10. PMID: 33758843; PMCID: PMC7987002.
      Citations: 1     
    42. Osipiuk J, Azizi SA, Dvorkin S, Endres M, Jedrzejczak R, Jones KA, Kang S, Kathayat RS, Kim Y, Lisnyak VG, Maki SL, Nicolaescu V, Taylor CA, Tesar C, Zhang YA, Zhou Z, Randall G, Michalska K, Snyder SA, Dickinson BC, Joachimiak A. Structure of papain-like protease from SARS-CoV-2 and its complexes with non-covalent inhibitors. Nat Commun. 2021 02 02; 12(1):743. PMID: 33531496; PMCID: PMC7854729.
      Citations: 232     Fields:    Translation:HumansCells
    43. Gupta Y, Maciorowski D, Zak SE, Jones KA, Kathayat RS, Azizi SA, Mathur R, Pearce CM, Ilc DJ, Husein H, Herbert AS, Bharti A, Rathi B, Durvasula R, Becker DP, Dickinson BC, Dye JM, Kempaiah P. Bisindolylmaleimide IX: A novel anti-SARS-CoV2 agent targeting viral main protease 3CLpro demonstrated by virtual screening pipeline and in-vitro validation assays. Methods. 2021 11; 195:57-71. PMID: 33453392; PMCID: PMC7807167.
      Citations: 22     Fields:    Translation:HumansCells
    44. Lippert AR, Dickinson BC, New EJ. Imaging Mitochondrial Hydrogen Peroxide in Living Cells. Methods Mol Biol. 2021; 2275:127-140. PMID: 34118035.
      Citations:    Fields:    Translation:HumansCells
    45. Rauch S, Jones KA, Dickinson BC. Small Molecule-Inducible RNA-Targeting Systems for Temporal Control of RNA Regulation. ACS Cent Sci. 2020 Nov 25; 6(11):1987-1996. PMID: 33274276; PMCID: PMC7706094.
      Citations: 24     
    46. Drayman N, Jones KA, Azizi SA, Froggatt HM, Tan K, Maltseva NI, Chen S, Nicolaescu V, Dvorkin S, Furlong K, Kathayat RS, Firpo MR, Mastrodomenico V, Bruce EA, Schmidt MM, Jedrzejczak R, Schuster B, Nair V, Botten JW, Brooke CB, Baker SC, Mounce BC, Heaton NS, Dickinson BC, Jaochimiak A, Randall G, Tay S, Muñoz-Alía MÁ. Drug repurposing screen identifies masitinib as a 3CLpro inhibitor that blocks replication of SARS-CoV-2 in vitro. bioRxiv. 2020 Sep 01. PMID: 32908976; PMCID: PMC7480023.
      Citations: 3     
    47. Dewey JA, Dickinson BC. Split T7 RNA polymerase biosensors to study multiprotein interaction dynamics. Methods Enzymol. 2020; 641:413-432. PMID: 32713533; PMCID: PMC8211417.
      Citations: 3     Fields:    Translation:AnimalsCells
    48. Wei X, Adak S, Zayed M, Yin L, Feng C, Speck SL, Kathayat RS, Zhang Q, Dickinson BC, Semenkovich CF. Endothelial Palmitoylation Cycling Coordinates Vessel Remodeling in Peripheral Artery Disease. Circ Res. 2020 07 03; 127(2):249-265. PMID: 32233916; PMCID: PMC7334103.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    49. Zinkus-Boltz J, DeValk C, Dickinson BC. A Phage-Assisted Continuous Selection Approach for Deep Mutational Scanning of Protein-Protein Interactions. ACS Chem Biol. 2019 12 20; 14(12):2757-2767. PMID: 31808666.
      Citations: 17     Fields:    Translation:Cells
    50. Cao Y, Qiu T, Kathayat RS, Azizi SA, Thorne AK, Ahn D, Fukata Y, Fukata M, Rice PA, Dickinson BC. ABHD10 is an S-depalmitoylase affecting redox homeostasis through peroxiredoxin-5. Nat Chem Biol. 2019 12; 15(12):1232-1240. PMID: 31740833; PMCID: PMC6871660.
      Citations: 66     Fields:    Translation:HumansCells
    51. Azizi SA, Kathayat RS, Dickinson BC. Activity-Based Sensing of S-Depalmitoylases: Chemical Technologies and Biological Discovery. Acc Chem Res. 2019 11 19; 52(11):3029-3038. PMID: 31577124; PMCID: PMC7201403.
      Citations: 17     Fields:    Translation:HumansCells
    52. Jones KA, Kentala K, Beck MW, An W, Lippert AR, Lewis JC, Dickinson BC. Development of a Split Esterase for Protein-Protein Interaction-Dependent Small-Molecule Activation. ACS Cent Sci. 2019 Nov 27; 5(11):1768-1776. PMID: 31807678; PMCID: PMC6891849.
      Citations: 17     
    53. Zhou H, Rauch S, Dai Q, Cui X, Zhang Z, Nachtergaele S, Sepich C, He C, Dickinson BC. Evolution of a reverse transcriptase to map N1-methyladenosine in human messenger RNA. Nat Methods. 2019 12; 16(12):1281-1288. PMID: 31548705; PMCID: PMC6884687.
      Citations: 110     Fields:    Translation:HumansCells
    54. Rauch S, Dickinson BC. Expanding the Chemical Scope of RNA Base Editors. Biochemistry. 2019 08 27; 58(34):3555-3556. PMID: 31411021.
      Citations:    Fields:    Translation:HumansCells
    55. Zingler P, Glatter T, Caning L, Saggau C, Kathayat RS, Dickinson BC, Adam D, Schneider-Brachert W, Särchen V, Schütze S, Fritsch J. Palmitoylation is required for TNF-R1 signaling. Cell Commun Signal. 2019 08 05; 17(1):90. PMID: 31382980; PMCID: PMC6683503.
      Citations: 27     Fields:    Translation:HumansCells
    56. Rauch S, He E, Srienc M, Zhou H, Zhang Z, Dickinson BC. Programmable RNA-Guided RNA Effector Proteins Built from Human Parts. Cell. 2019 Jun 27; 178(1):122-134.e12. PMID: 31230714; PMCID: PMC6657360.
      Citations: 80     Fields:    Translation:HumansCells
    57. Pu J, Disare M, Dickinson BC. Evolution of C-Terminal Modification Tolerance in Full-Length and Split T7 RNA Polymerase Biosensors. Chembiochem. 2019 06 14; 20(12):1547-1553. PMID: 30694596; PMCID: PMC6570552.
      Citations: 13     Fields:    Translation:Cells
    58. Rauch S, Dickinson BC. Targeted m6A reader proteins to study the epitranscriptome. Methods Enzymol. 2019; 621:1-16. PMID: 31128773.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    59. Kathayat RS, Dickinson BC. Measuring S-Depalmitoylation Activity In Vitro and In Live Cells with Fluorescent Probes. Methods Mol Biol. 2019; 2009:99-109. PMID: 31152398; PMCID: PMC7240838.
      Citations: 3     Fields:    Translation:HumansCells
    60. Rauch S, He C, Dickinson BC. Targeted m6A Reader Proteins To Study Epitranscriptomic Regulation of Single RNAs. J Am Chem Soc. 2018 09 26; 140(38):11974-11981. PMID: 30183280; PMCID: PMC6436614.
      Citations: 68     Fields:    Translation:HumansCells
    61. Dickinson BC. Controlling protein function with HCV protease. Nat Methods. 2018 07; 15(7):489-490. PMID: 29967494.
      Citations: 1     Fields:    Translation:Humans
    62. Sadeghi RS, Kulej K, Kathayat RS, Garcia BA, Dickinson BC, Brady DC, Witze ES. Wnt5a signaling induced phosphorylation increases APT1 activity and promotes melanoma metastatic behavior. Elife. 2018 04 12; 7. PMID: 29648538; PMCID: PMC5919757.
      Citations: 29     Fields:    Translation:HumansCells
    63. Kathayat RS, Cao Y, Elvira PD, Springer MZ, Drake LE, Macleod KF, Dickinson BC, Sandoz PA, Zaballa ME, van der Goot FG. Active and dynamic mitochondrial S-depalmitoylation revealed by targeted fluorescent probes. Nat Commun. 2018 01 23; 9(1):334. PMID: 29362370; PMCID: PMC5780395.
      Citations: 51     Fields:    Translation:HumansCells
    64. Rauch S, Dickinson BC. Programmable RNA Binding Proteins for Imaging and Therapeutics. Biochemistry. 2018 01 30; 57(4):363-364. PMID: 29148777; PMCID: PMC5826540.
      Citations: 4     Fields:    Translation:HumansCells
    65. Qiu T, Kathayat RS, Cao Y, Beck MW, Dickinson BC. A Fluorescent Probe with Improved Water Solubility Permits the Analysis of Protein S-Depalmitoylation Activity in Live Cells. Biochemistry. 2018 01 16; 57(2):221-225. PMID: 29023093; PMCID: PMC5823605.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    66. Beck MW, Kathayat RS, Cham CM, Chang EB, Dickinson BC. Correction: Michael addition-based probes for ratiometric fluorescence imaging of protein S-depalmitoylases in live cells and tissues. Chem Sci. 2017 11 01; 8(11):7879. PMID: 30123473; PMCID: PMC6063153.
      Citations:    
    67. Beck MW, Kathayat RS, Cham CM, Chang EB, Dickinson BC. Michael addition-based probes for ratiometric fluorescence imaging of protein S-depalmitoylases in live cells and tissues. Chem Sci. 2017 Nov 01; 8(11):7588-7592. PMID: 29568422; PMCID: PMC5848818.
      Citations: 16     
    68. Pu J, Kentala K, Dickinson BC. Multidimensional Control of Cas9 by Evolved RNA Polymerase-Based Biosensors. ACS Chem Biol. 2018 02 16; 13(2):431-437. PMID: 28809467; PMCID: PMC5828011.
      Citations: 16     Fields:    Translation:HumansCells
    69. Pu J, Dewey JA, Hadji A, LaBelle JL, Dickinson BC. RNA Polymerase Tags To Monitor Multidimensional Protein-Protein Interactions Reveal Pharmacological Engagement of Bcl-2 Proteins. J Am Chem Soc. 2017 08 30; 139(34):11964-11972. PMID: 28767232; PMCID: PMC5828006.
      Citations: 9     Fields:    Translation:HumansCells
    70. Pu J, Zinkus-Boltz J, Dickinson BC. Evolution of a split RNA polymerase as a versatile biosensor platform. Nat Chem Biol. 2017 04; 13(4):432-438. PMID: 28192413; PMCID: PMC5823606.
      Citations: 66     Fields:    Translation:HumansCells
    71. Kathayat RS, Elvira PD, Dickinson BC. A fluorescent probe for cysteine depalmitoylation reveals dynamic APT signaling. Nat Chem Biol. 2017 02; 13(2):150-152. PMID: 27992880; PMCID: PMC5247352.
      Citations: 38     Fields:    Translation:HumansCells
    72. Tong Q, Zhu Y, Galaske JW, Kosmacek EA, Chatterjee A, Dickinson BC, Oberley-Deegan RE. MnTE-2-PyP modulates thiol oxidation in a hydrogen peroxide-mediated manner in a human prostate cancer cell. Free Radic Biol Med. 2016 12; 101:32-43. PMID: 27671770; PMCID: PMC5486925.
      Citations: 21     Fields:    Translation:HumansCells
    73. Cox AG, Tsomides A, Kim AJ, Saunders D, Hwang KL, Evason KJ, Heidel J, Brown KK, Yuan M, Lien EC, Lee BC, Nissim S, Dickinson B, Chhangawala S, Chang CJ, Asara JM, Houvras Y, Gladyshev VN, Goessling W. Selenoprotein H is an essential regulator of redox homeostasis that cooperates with p53 in development and tumorigenesis. Proc Natl Acad Sci U S A. 2016 09 20; 113(38):E5562-71. PMID: 27588899; PMCID: PMC5035897.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    74. Tomalin LE, Day AM, Underwood ZE, Smith GR, Dalle Pezze P, Rallis C, Patel W, Dickinson BC, Brewer TF, Chang CJ, Shanley DP, Veal EA, Bähler J. Increasing extracellular H2O2 produces a bi-phasic response in intracellular H2O2, with peroxiredoxin hyperoxidation only triggered once the cellular H2O2-buffering capacity is overwhelmed. Free Radic Biol Med. 2016 06; 95:333-48. PMID: 26944189; PMCID: PMC4891068.
      Citations: 19     Fields:    Translation:Cells
    75. Pu J, Chronis I, Ahn D, Dickinson BC. A Panel of Protease-Responsive RNA Polymerases Respond to Biochemical Signals by Production of Defined RNA Outputs in Live Cells. J Am Chem Soc. 2015 Dec 30; 137(51):15996-9. PMID: 26652972; PMCID: PMC5070793.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    76. Dickinson BC. Metabolism: Plugging the leak. Nat Chem Biol. 2015 Nov; 11(11):831-2. PMID: 26485078.
      Citations:    Fields:    Translation:HumansAnimalsCells
    77. Fu X, Tang Y, Dickinson BC, Chang CJ, Chang Z. An oxidative fluctuation hypothesis of aging generated by imaging H2O2 levels in live Caenorhabditis elegans with altered lifespans. Biochem Biophys Res Commun. 2015 Mar 20; 458(4):896-900. PMID: 25701790.
      Citations: 9     Fields:    Translation:Animals
    78. Lippert AR, Dickinson BC, New EJ. Imaging mitochondrial hydrogen peroxide in living cells. Methods Mol Biol. 2015; 1264:231-43. PMID: 25631018.
      Citations: 4     Fields:    Translation:HumansCells
    79. Dickinson BC, Packer MS, Badran AH, Liu DR. A system for the continuous directed evolution of proteases rapidly reveals drug-resistance mutations. Nat Commun. 2014 Oct 30; 5:5352. PMID: 25355134; PMCID: PMC4215169.
      Citations: 50     Fields:    Translation:HumansCells
    80. Guo H, Aleyasin H, Howard SS, Dickinson BC, Lin VS, Haskew-Layton RE, Xu C, Chen Y, Ratan RR. Two-photon fluorescence imaging of intracellular hydrogen peroxide with chemoselective fluorescent probes. J Biomed Opt. 2013 Oct; 18(10):106002. PMID: 24084856; PMCID: PMC3787808.
      Citations: 6     Fields:    Translation:AnimalsCells
    81. Dickinson BC, Lin VS, Chang CJ. Preparation and use of MitoPY1 for imaging hydrogen peroxide in mitochondria of live cells. Nat Protoc. 2013 Jun; 8(6):1249-59. PMID: 23722262; PMCID: PMC4096497.
      Citations: 66     Fields:    Translation:HumansCells
    82. Dickinson BC, Leconte AM, Allen B, Esvelt KM, Liu DR. Experimental interrogation of the path dependence and stochasticity of protein evolution using phage-assisted continuous evolution. Proc Natl Acad Sci U S A. 2013 May 28; 110(22):9007-12. PMID: 23674678; PMCID: PMC3670371.
      Citations: 65     Fields:    Translation:Cells
    83. Leconte AM, Dickinson BC, Yang DD, Chen IA, Allen B, Liu DR. A population-based experimental model for protein evolution: effects of mutation rate and selection stringency on evolutionary outcomes. Biochemistry. 2013 Feb 26; 52(8):1490-9. PMID: 23360105; PMCID: PMC3641671.
      Citations: 29     Fields:    Translation:Cells
    84. Lin VS, Dickinson BC, Chang CJ. Boronate-based fluorescent probes: imaging hydrogen peroxide in living systems. Methods Enzymol. 2013; 526:19-43. PMID: 23791092; PMCID: PMC4096516.
      Citations: 49     Fields:    Translation:HumansAnimals
    85. Woolley JF, Naughton R, Stanicka J, Gough DR, Bhatt L, Dickinson BC, Chang CJ, Cotter TG. H2O2 production downstream of FLT3 is mediated by p22phox in the endoplasmic reticulum and is required for STAT5 signalling. PLoS One. 2012; 7(7):e34050. PMID: 22807997; PMCID: PMC3396659.
      Citations: 29     Fields:    Translation:HumansCells
    86. Dickinson BC, Tang Y, Chang Z, Chang CJ. A nuclear-localized fluorescent hydrogen peroxide probe for monitoring sirtuin-mediated oxidative stress responses in vivo. Chem Biol. 2011 Aug 26; 18(8):943-8. PMID: 21867909; PMCID: PMC3173257.
      Citations: 51     Fields:    Translation:HumansAnimalsCells
    87. Dickinson BC, Chang CJ. Chemistry and biology of reactive oxygen species in signaling or stress responses. Nat Chem Biol. 2011 Jul 18; 7(8):504-11. PMID: 21769097; PMCID: PMC3390228.
      Citations: 510     Fields:    Translation:Cells
    88. Dickinson BC, Peltier J, Stone D, Schaffer DV, Chang CJ. Nox2 redox signaling maintains essential cell populations in the brain. Nat Chem Biol. 2011 Feb; 7(2):106-12. PMID: 21186346; PMCID: PMC3023843.
      Citations: 132     Fields:    Translation:Cells
    89. Miller EW, Dickinson BC, Chang CJ. Aquaporin-3 mediates hydrogen peroxide uptake to regulate downstream intracellular signaling. Proc Natl Acad Sci U S A. 2010 Sep 07; 107(36):15681-6. PMID: 20724658; PMCID: PMC2936599.
      Citations: 304     Fields:    Translation:HumansAnimalsCells
    90. Dickinson BC, Huynh C, Chang CJ. A palette of fluorescent probes with varying emission colors for imaging hydrogen peroxide signaling in living cells. J Am Chem Soc. 2010 Apr 28; 132(16):5906-15. PMID: 20361787; PMCID: PMC2862989.
      Citations: 147     Fields:    Translation:HumansAnimalsCells
    91. Dickinson BC, Srikun D, Chang CJ. Mitochondrial-targeted fluorescent probes for reactive oxygen species. Curr Opin Chem Biol. 2010 Feb; 14(1):50-6. PMID: 19910238; PMCID: PMC2830890.
      Citations: 69     Fields:    Translation:Cells
    92. Sims JJ, Haririnia A, Dickinson BC, Fushman D, Cohen RE. Avid interactions underlie the Lys63-linked polyubiquitin binding specificities observed for UBA domains. Nat Struct Mol Biol. 2009 Aug; 16(8):883-9. PMID: 19620964; PMCID: PMC2744598.
      Citations: 52     Fields:    Translation:Cells
    93. Albers AE, Dickinson BC, Miller EW, Chang CJ. A red-emitting naphthofluorescein-based fluorescent probe for selective detection of hydrogen peroxide in living cells. Bioorg Med Chem Lett. 2008 Nov 15; 18(22):5948-50. PMID: 18762422; PMCID: PMC2590631.
      Citations: 19     Fields:    Translation:AnimalsCells
    94. Dickinson BC, Chang CJ. A targetable fluorescent probe for imaging hydrogen peroxide in the mitochondria of living cells. J Am Chem Soc. 2008 Jul 30; 130(30):9638-9. PMID: 18605728; PMCID: PMC2810491.
      Citations: 179     Fields:    Translation:HumansAnimalsCells
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