"Ouabain" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A cardioactive glycoside consisting of rhamnose and ouabagenin, obtained from the seeds of Strophanthus gratus and other plants of the Apocynaceae; used like DIGITALIS. It is commonly used in cell biological studies as an inhibitor of the NA(+)-K(+)-EXCHANGING ATPASE.
- G Strophanthin
- Acolongifloroside K
Below are MeSH descriptors whose meaning is more general than "Ouabain".
Below are MeSH descriptors whose meaning is more specific than "Ouabain".
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Below are the most recent publications written about "Ouabain" by people in Profiles.
Telocinobufagin, a Novel Cardiotonic Steroid, Promotes Renal Fibrosis via Na?/K?-ATPase Profibrotic Signaling Pathways. Int J Mol Sci. 2018 Aug 29; 19(9).
Regulation of myofibroblast differentiation by cardiac glycosides. Am J Physiol Lung Cell Mol Physiol. 2016 05 01; 310(9):L815-23.
Critical role of the a1-Na(+), K(+)-ATPase subunit in insensitivity of rodent cells to cytotoxic action of ouabain. Apoptosis. 2015 Sep; 20(9):1200-10.
Novel mutations in ATP1A3 associated with catastrophic early life epilepsy, episodic prolonged apnea, and postnatal microcephaly. Epilepsia. 2015 Mar; 56(3):422-30.
A structural rearrangement of the Na+/K+-ATPase traps ouabain within the external ion permeation pathway. J Mol Biol. 2015 Mar 27; 427(6 Pt B):1335-1344.
Ouabain inhibits placental sFlt1 production by repressing HSP27-dependent HIF-1a pathway. FASEB J. 2014 Oct; 28(10):4324-34.
Ouabain binding site in a functioning Na+/K+ ATPase. J Biol Chem. 2011 Nov 04; 286(44):38177-38183.
Vastus lateralis Na(+)-K(+)-ATPase activity, protein, and isoform distribution in chronic obstructive pulmonary disease. Muscle Nerve. 2009 Jul; 40(1):62-8.
[Na]i -induced c-Fos expression is not mediated by activation of the 5' -promoter containing known transcriptional elements. FEBS J. 2007 Jul; 274(14):3557-3567.
The relation of brain ouabain-like compounds and idiopathic intracranial hypertension. Headache. 2006 Sep; 46(8):1255-60.