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Vukica Srajer

TitleResearch Professor
InstitutionUniversity of Chicago
DepartmentBiochemistry and Molecular Biology
AddressChicago IL 60637
Phone+1 (630) 252 0455
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    P41GM118217     (RANGANATHAN, RAMA)Feb 1, 2019 - Jan 31, 2022
    BioCARS: Structural Dynamics and Biological Mechanisms
    Role: Co-Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Kosheleva I, Henning R, Kim I, Kim SO, Kusel M, Srajer V. Sample-minimizing co-flow cell for time-resolved pump-probe X-ray solution scattering. J Synchrotron Radiat. 2023 Mar 01; 30(Pt 2):490-499. PMID: 36891863; PMCID: PMC10000795.
      Citations: 2     Fields:    Translation:Cells
    2. Wilamowski M, Sherrell DA, Kim Y, Lavens A, Henning RW, Lazarski K, Shigemoto A, Endres M, Maltseva N, Babnigg G, Burdette SC, Srajer V, Joachimiak A. Time-resolved ß-lactam cleavage by L1 metallo-ß-lactamase. Nat Commun. 2022 11 30; 13(1):7379. PMID: 36450742; PMCID: PMC9712583.
      Citations: 8     Fields:    
    3. Moreno-Chicano T, Carey LM, Axford D, Beale JH, Doak RB, Duyvesteyn HME, Ebrahim A, Henning RW, Monteiro DCF, Myles DA, Owada S, Sherrell DA, Straw ML, Šrajer V, Sugimoto H, Tono K, Tosha T, Tews I, Trebbin M, Strange RW, Weiss KL, Worrall JAR, Meilleur F, Owen RL, Ghiladi RA, Hough MA. Complementarity of neutron, XFEL and synchrotron crystallography for defining the structures of metalloenzymes at room temperature. IUCrJ. 2022 Sep 01; 9(Pt 5):610-624. PMID: 36071813; PMCID: PMC9438502.
      Citations: 2     Fields:    
    4. Carrillo M, Pandey S, Sanchez J, Noda M, Poudyal I, Aldama L, Malla TN, Claesson E, Wahlgren WY, Feliz D, Šrajer V, Maj M, Castillon L, Iwata S, Nango E, Tanaka R, Tanaka T, Fangjia L, Tono K, Owada S, Westenhoff S, Stojkovic EA, Schmidt M. High-resolution crystal structures of transient intermediates in the phytochrome photocycle. Structure. 2021 07 01; 29(7):743-754.e4. PMID: 33756101; PMCID: PMC8405169.
      Citations: 17     Fields:    Translation:Cells
    5. Sanchez JC, Carrillo M, Pandey S, Noda M, Aldama L, Feliz D, Claesson E, Wahlgren WY, Tracy G, Duong P, Nugent AC, Field A, Šrajer V, Kupitz C, Iwata S, Nango E, Tanaka R, Tanaka T, Fangjia L, Tono K, Owada S, Westenhoff S, Schmidt M, Stojkovic EA. High-resolution crystal structures of a myxobacterial phytochrome at cryo and room temperatures. Struct Dyn. 2019 Sep; 6(5):054701. PMID: 31559319; PMCID: PMC6748860.
      Citations: 12     
    6. Meents A, Wiedorn MO, Srajer V, Henning R, Sarrou I, Bergtholdt J, Barthelmess M, Dierksmeyer D, Tolstikova A, Schaible S, Messerschmidt M, Ogata CM, Kissick DJ, Lieske J, Oberthuer D, Fischetti RF, Chapman HN, Reinke PYA, Taft MH, Manstein DJ. Pink-beam serial crystallography. Nat Commun. 2017 11 03; 8(1):1281. PMID: 29097720; PMCID: PMC5668288.
      Citations: 39     Fields:    Translation:Cells
    7. Šrajer V, Schmidt M. Watching Proteins Function with Time-resolved X-ray Crystallography. J Phys D Appl Phys. 2017 09 20; 50(37). PMID: 29353938; PMCID: PMC5771432.
      Citations: 25     
    8. Hekstra DR, White KI, Socolich MA, Henning RW, Ranganathan R, Šrajer V. Electric-field-stimulated protein mechanics. Nature. 2016 12 15; 540(7633):400-405. PMID: 27926732; PMCID: PMC5730412.
      Citations: 72     Fields:    Translation:HumansCells
    9. Sui S, Wang Y, Kolewe KW, Srajer V, Henning R, Schiffman JD, Dimitrakopoulos C, Perry SL. Graphene-based microfluidics for serial crystallography. Lab Chip. 2016 08 02; 16(16):3082-96. PMID: 27241728; PMCID: PMC4970872.
      Citations: 19     Fields:    Translation:Cells
    10. Pande K, Hutchison CD, Aquila A, Robinson JS, Tenboer J, Basu S, DePonte DP, Liang M, White TA, Zatsepin NA, Yefanov O, Oberthuer D, Gati C, Subramanian G, James D, Zhao Y, Koralek J, Brayshaw J, Kupitz C, Conrad C, Roy-Chowdhury S, Coe JD, Metz M, Xavier PL, Grant TD, Koglin JE, Ketawala G, Fromme R, Henning R, Spence JC, Ourmazd A, Schwander P, Weierstall U, Frank M, Fromme P, Barty A, Chapman HN, Moffat K, van Thor JJ, Schmidt M, Groenhof G, Boutet S, Morozov D, Šrajer V. Femtosecond structural dynamics drives the trans/cis isomerization in photoactive yellow protein. Science. 2016 May 06; 352(6286):725-9. PMID: 27151871; PMCID: PMC5291079.
      Citations: 149     Fields:    Translation:Cells
    11. Pawate AS, Schieferstein J, Guha S, Henning R, Kosheleva I, Schmidt M, Ren Z, Kenis PJ, Perry SL, Šrajer V. Towards time-resolved serial crystallography in a microfluidic device. Acta Crystallogr F Struct Biol Commun. 2015 Jul; 71(Pt 7):823-30. PMID: 26144226; PMCID: PMC4498702.
      Citations: 13     Fields:    Translation:Cells
    12. Kaucikas M, Fitzpatrick A, Bryan E, Struve A, Henning R, Kosheleva I, Srajer V, Groenhof G, Van Thor JJ. Room temperature crystal structure of the fast switching M159T mutant of the fluorescent protein dronpa. Proteins. 2015 Mar; 83(3):397-402. PMID: 25524427; PMCID: PMC4494737.
      Citations: 1     Fields:    Translation:AnimalsCells
    13. Tenboer J, Basu S, Zatsepin N, Pande K, Milathianaki D, Frank M, Hunter M, Williams GJ, Koglin JE, Oberthuer D, Heymann M, Kupitz C, Conrad C, Coe J, Roy-Chowdhury S, Weierstall U, James D, Wang D, Grant T, Barty A, Yefanov O, Scales J, Gati C, Seuring C, Srajer V, Henning R, Schwander P, Fromme R, Ourmazd A, Moffat K, Van Thor JJ, Spence JC, Fromme P, Chapman HN, Schmidt M, Boutet S. Time-resolved serial crystallography captures high-resolution intermediates of photoactive yellow protein. Science. 2014 12 05; 346(6214):1242-6. PMID: 25477465; PMCID: PMC4361027.
      Citations: 222     Fields:    Translation:Cells
    14. Perry SL, Guha S, Pawate AS, Henning R, Kosheleva I, Srajer V, Kenis PJ, Ren Z. In situ serial Laue diffraction on a microfluidic crystallization device. J Appl Crystallogr. 2014 Dec 01; 47(Pt 6):1975-1982. PMID: 25484843; PMCID: PMC4248567.
      Citations: 19     
    15. van Thor JJ, Warren MM, Lincoln CN, Chollet M, Lemke HT, Fritz DM, Schmidt M, Tenboer J, Ren Z, Srajer V, Moffat K, Graber T. Signal to noise considerations for single crystal femtosecond time resolved crystallography of the Photoactive Yellow Protein. Faraday Discuss. 2014; 171:439-55. PMID: 25415305.
      Citations: 12     Fields:    
    16. Jung YO, Lee JH, Kim J, Schmidt M, Moffat K, Šrajer V, Ihee H. Reply to 'contradictions in X-ray structures of intermediates in the photocycle of photoactive yellow protein'. Nat Chem. 2014 Apr; 6(4):259-60. PMID: 24651179; PMCID: PMC4072662.
      Citations: 10     Fields:    
    17. Schmidt M, Srajer V, Henning R, Ihee H, Purwar N, Tenboer J, Tripathi S. Protein energy landscapes determined by five-dimensional crystallography. Acta Crystallogr D Biol Crystallogr. 2013 Dec; 69(Pt 12):2534-42. PMID: 24311594; PMCID: PMC3852658.
      Citations: 34     Fields:    Translation:Cells
    18. Zhao J, Srajer V, Franzen S. Functional consequences of the open distal pocket of dehaloperoxidase-hemoglobin observed by time-resolved X-ray crystallography. Biochemistry. 2013 Nov 12; 52(45):7943-50. PMID: 24116924; PMCID: PMC3983922.
      Citations: 1     Fields:    Translation:Cells
    19. Ren Z, Chan PW, Moffat K, Pai EF, Royer WE, Šrajer V, Yang X. Resolution of structural heterogeneity in dynamic crystallography. Acta Crystallogr D Biol Crystallogr. 2013 Jun; 69(Pt 6):946-59. PMID: 23695239; PMCID: PMC3663119.
      Citations: 21     Fields:    
    20. Jung YO, Lee JH, Kim J, Schmidt M, Moffat K, Srajer V, Ihee H. Volume-conserving trans-cis isomerization pathways in photoactive yellow protein visualized by picosecond X-ray crystallography. Nat Chem. 2013 Mar; 5(3):212-20. PMID: 23422563; PMCID: PMC3579544.
      Citations: 74     Fields:    Translation:Cells
    21. Youngblut M, Judd ET, Srajer V, Sayyed B, Goelzer T, Elliott SJ, Schmidt M, Pacheco AA. Laue crystal structure of Shewanella oneidensis cytochrome c nitrite reductase from a high-yield expression system. J Biol Inorg Chem. 2012 Apr; 17(4):647-62. PMID: 22382353; PMCID: PMC3412176.
      Citations: 17     Fields:    Translation:Cells
    22. Tripathi S, Srajer V, Purwar N, Henning R, Schmidt M. pH dependence of the photoactive yellow protein photocycle investigated by time-resolved crystallography. Biophys J. 2012 Jan 18; 102(2):325-32. PMID: 22339869; PMCID: PMC3260688.
      Citations: 22     Fields:    
    23. Schmidt M, Šrajer V, Purwar N, Tripathi S. The kinetic dose limit in room-temperature time-resolved macromolecular crystallography. J Synchrotron Radiat. 2012 Mar; 19(Pt 2):264-73. PMID: 22338689; PMCID: PMC3284346.
      Citations: 10     Fields:    
    24. Ren Z, Srajer V, Knapp JE, Royer WE. Cooperative macromolecular device revealed by meta-analysis of static and time-resolved structures. Proc Natl Acad Sci U S A. 2012 Jan 03; 109(1):107-12. PMID: 22171006; PMCID: PMC3252913.
      Citations: 25     Fields:    Translation:AnimalsCells
    25. Graber T, Anderson S, Brewer H, Chen YS, Cho HS, Dashdorj N, Henning RW, Kosheleva I, Macha G, Meron M, Pahl R, Ren Z, Ruan S, Schotte F, Srajer V, Viccaro PJ, Westferro F, Anfinrud P, Moffat K. BioCARS: a synchrotron resource for time-resolved X-ray science. J Synchrotron Radiat. 2011 Jul; 18(Pt 4):658-70. PMID: 21685684; PMCID: PMC3121234.
      Citations: 56     Fields:    
    26. Schmidt M, Graber T, Henning R, Srajer V. Five-dimensional crystallography. Acta Crystallogr A. 2010 Mar; 66(Pt 2):198-206. PMID: 20164643; PMCID: PMC2824529.
      Citations: 16     Fields:    Translation:Cells
    27. Knapp JE, Pahl R, Cohen J, Nichols JC, Schulten K, Gibson QH, Srajer V, Royer WE. Ligand migration and cavities within Scapharca Dimeric HbI: studies by time-resolved crystallo-graphy, Xe binding, and computational analysis. Structure. 2009 Nov 11; 17(11):1494-504. PMID: 19913484; PMCID: PMC2785043.
      Citations: 32     Fields:    Translation:AnimalsCells
    28. Srajer V, Royer WE. Time-resolved x-ray crystallography of heme proteins. Methods Enzymol. 2008; 437:379-95. PMID: 18433638; PMCID: PMC3287071.
      Citations: 9     Fields:    Translation:AnimalsCells
    29. Key J, Srajer V, Pahl R, Moffat K. Time-resolved crystallographic studies of the heme domain of the oxygen sensor FixL: structural dynamics of ligand rebinding and their relation to signal transduction. Biochemistry. 2007 Apr 24; 46(16):4706-15. PMID: 17385895.
      Citations: 15     Fields:    Translation:Cells
    30. Knapp JE, Pahl R, Srajer V, Royer WE. Allosteric action in real time: time-resolved crystallographic studies of a cooperative dimeric hemoglobin. Proc Natl Acad Sci U S A. 2006 May 16; 103(20):7649-54. PMID: 16684887; PMCID: PMC1472499.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    31. Nienhaus K, Pahl R, Krasselt A, Anderson S, Parak F, Nienhaus GU, Srajer V, Schmidt M. Ligand migration pathway and protein dynamics in myoglobin: a time-resolved crystallographic study on L29W MbCO. Proc Natl Acad Sci U S A. 2005 Aug 16; 102(33):11704-9. PMID: 16085709; PMCID: PMC1187994.
      Citations: 66     Fields:    Translation:Cells
    32. Ihee H, Rajagopal S, Srajer V, Pahl R, Anderson S, Schmidt M, Schotte F, Anfinrud PA, Wulff M, Moffat K. Visualizing reaction pathways in photoactive yellow protein from nanoseconds to seconds. Proc Natl Acad Sci U S A. 2005 May 17; 102(20):7145-50. PMID: 15870207; PMCID: PMC1088170.
      Citations: 91     Fields:    Translation:Cells
    33. Rajagopal S, Anderson S, Srajer V, Schmidt M, Pahl R, Moffat K. A structural pathway for signaling in the E46Q mutant of photoactive yellow protein. Structure. 2005 Jan; 13(1):55-63. PMID: 15642261.
      Citations: 29     Fields:    Translation:Cells
    34. Schmidt M, Ihee H, Pahl R, Srajer V. Protein-ligand interaction probed by time-resolved crystallography. Methods Mol Biol. 2005; 305:115-54. PMID: 15939996.
      Citations: 14     Fields:    Translation:Cells
    35. Anderson S, Srajer V, Moffat K. Structural heterogeneity of cryotrapped intermediates in the bacterial blue light photoreceptor, photoactive yellow protein. Photochem Photobiol. 2004 Jul-Aug; 80:7-14. PMID: 15339224.
      Citations: 12     Fields:    Translation:Cells
    36. Anderson S, Srajer V, Pahl R, Rajagopal S, Schotte F, Anfinrud P, Wulff M, Moffat K. Chromophore conformation and the evolution of tertiary structural changes in photoactive yellow protein. Structure. 2004 Jun; 12(6):1039-45. PMID: 15274923.
      Citations: 19     Fields:    Translation:Cells
    37. Baxter RH, Ponomarenko N, Srajer V, Pahl R, Moffat K, Norris JR. Time-resolved crystallographic studies of light-induced structural changes in the photosynthetic reaction center. Proc Natl Acad Sci U S A. 2004 Apr 20; 101(16):5982-7. PMID: 15073325; PMCID: PMC395909.
      Citations: 17     Fields:    Translation:Cells
    38. Pahl R, Srajer V, Anderson S, Ren Z, Ihee H, Rajagopal S, Moffat K, Schmidt M. Protein kinetics: structures of intermediates and reaction mechanism from time-resolved x-ray data. Proc Natl Acad Sci U S A. 2004 Apr 06; 101(14):4799-804. PMID: 15041745; PMCID: PMC387328.
      Citations: 38     Fields:    
    39. Knapp JE, Srajer V, Pahl R, Royer WE. Immobilization of Scapharca HbI crystals improves data quality in time-resolved crystallographic experiments. Micron. 2004; 35(1-2):107-8. PMID: 15036308.
      Citations: 3     Fields:    Translation:Animals
    40. Ren Z, Perman B, Srajer V, Teng TY, Pradervand C, Bourgeois D, Schotte F, Ursby T, Kort R, Wulff M, Moffat K. A molecular movie at 1.8 A resolution displays the photocycle of photoactive yellow protein, a eubacterial blue-light receptor, from nanoseconds to seconds. Biochemistry. 2001 Nov 20; 40(46):13788-801. PMID: 11705368.
      Citations: 53     Fields:    Translation:Cells
    41. Srajer V, Ren Z, Teng TY, Schmidt M, Ursby T, Bourgeois D, Pradervand C, Schildkamp W, Wulff M, Moffat K. Protein conformational relaxation and ligand migration in myoglobin: a nanosecond to millisecond molecular movie from time-resolved Laue X-ray diffraction. Biochemistry. 2001 Nov 20; 40(46):13802-15. PMID: 11705369.
      Citations: 112     Fields:    Translation:AnimalsCells
    42. Srajer V, Crosson S, Schmidt M, Key J, Schotte F, Anderson S, Perman B, Ren Z, Teng TY, Bourgeois D, Wulff M, Moffat K. Extraction of accurate structure-factor amplitudes from Laue data: wavelength normalization with wiggler and undulator X-ray sources. J Synchrotron Radiat. 2000 Jul 01; 7(Pt 4):236-44. PMID: 16609201.
      Citations: 14     Fields:    
    43. Perman B, Srajer V, Ren Z, Teng T, Pradervand C, Ursby T, Bourgeois D, Schotte F, Wulff M, Kort R, Hellingwerf K, Moffat K. Energy transduction on the nanosecond time scale: early structural events in a xanthopsin photocycle. Science. 1998 Mar 20; 279(5358):1946-50. PMID: 9506946.
      Citations: 42     Fields:    Translation:Cells
    44. Teng TY, Srajer V, Moffat K. Initial trajectory of carbon monoxide after photodissociation from myoglobin at cryogenic temperatures. Biochemistry. 1997 Oct 07; 36(40):12087-100. PMID: 9315847.
      Citations: 15     Fields:    Translation:Cells
    45. Genick UK, Borgstahl GE, Ng K, Ren Z, Pradervand C, Burke PM, Srajer V, Teng TY, Schildkamp W, McRee DE, Moffat K, Getzoff ED. Structure of a protein photocycle intermediate by millisecond time-resolved crystallography. Science. 1997 Mar 07; 275(5305):1471-5. PMID: 9045611.
      Citations: 112     Fields:    Translation:Cells
    46. Srajer V, Teng T, Ursby T, Pradervand C, Ren Z, Adachi S, Schildkamp W, Bourgeois D, Wulff M, Moffat K. Photolysis of the carbon monoxide complex of myoglobin: nanosecond time-resolved crystallography. Science. 1996 Dec 06; 274(5293):1726-9. PMID: 8939867.
      Citations: 108     Fields:    Translation:Cells
    47. Bourgeois D, Ursby T, Wulff M, Pradervand C, Legrand A, Schildkamp W, Srajer V, Teng TY, Roth M, Moffat K, Labouré S. Feasibility and Realization of Single-Pulse Laue Diffraction on Macromolecular Crystals at ESRF. J Synchrotron Radiat. 1996 Mar 01; 3(Pt 2):65-74. PMID: 16702661.
      Citations: 13     Fields:    
    48. Teng TY, Srajer V, Moffat K. Photolysis-induced structural changes in single crystals of carbonmonoxy myoglobin at 40 K. Nat Struct Biol. 1994 Oct; 1(10):701-5. PMID: 7634074.
      Citations: 47     Fields:    Translation:AnimalsCells
    49. Tian WD, Sage JT, Srajer V, Champion PM. Relaxation dynamics of myoglobin in solution. Phys Rev Lett. 1992 Jan 20; 68(3):408-411. PMID: 10045884.
      Citations: 27     Fields:    
    50. Srajer V, Champion PM. Investigations of optical line shapes and kinetic hole burning in myoglobin. Biochemistry. 1991 Jul 30; 30(30):7390-402. PMID: 1854744.
      Citations: 31     Fields:    Translation:Cells
    51. Srajer V, Reinisch L, Champion PM. Investigation of laser-induced long-lived states of photolyzed MbCO. Biochemistry. 1991 May 21; 30(20):4886-95. PMID: 2036357.
      Citations: 13     Fields:    Translation:AnimalsCells
    52. Srajer V, Schomacker KT, Champion PM. Spectral broadening in biomolecules. Phys Rev Lett. 1986 Sep 08; 57(10):1267-1270. PMID: 10033400.
      Citations: 28     Fields:    
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