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Marcos Sotomayor

TitleProfessor
InstitutionUniversity of Chicago
DepartmentBiochemistry and Molecular Biology
AddressChicago IL 60637
Phone+1 (773) 7026345
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    Collapse Research 
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    R01DC020190     (INDZHYKULIAN, ARTUR)Jun 17, 2022 - May 31, 2027
    NIH
    Development of Gene Therapy for Hereditary Deafness using Rational Protein Engineering
    Role: Co-Principal Investigator
    R01DC015271     (SOTOMAYOR, MARCOS)Apr 1, 2016 - Jun 30, 2027
    NIH
    Nanomechanics of inner-ear hair-cell transduction
    Role: Principal Investigator
    R00DC012534     (SOTOMAYOR, MARCOS)Jul 16, 2013 - Jun 30, 2017
    NIH
    FORCE SPECTROSCOPY AND STRUCTURAL BIOLOGY OF HAIR-CELL TIP LINKS
    Role: Principal Investigator
    K99DC012534     (SOTOMAYOR, MARCOS)Jul 1, 2012 - Jul 15, 2013
    NIH
    FORCE SPECTROSCOPY AND STRUCTURAL BIOLOGY OF HAIR-CELL TIP LINKS
    Role: Principal Investigator
    R01DC000304     (COREY, DAVID P)Sep 1, 1984 - Nov 30, 2028
    NIH
    Molecular Mechanisms of Auditory Transduction
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Lee H, Park YC, Wen H, Smith HE, Balaraman J, Cui R, Sotomayor M, Ballesteros A. TMC1 and TMC2 are cholesterol-dependent scramblases that regulate membrane homeostasis in auditory hair cells. bioRxiv. 2025 Jul 04. PMID: 40631239; PMCID: PMC12236488.
      Citations:    
    2. Smith HE, Harrison-Rawn T, Zheng W, Ballesteros A, Sotomayor M. Groove architecture controls lipid scrambling in simulations of protein and model systems. bioRxiv. 2025 Jul 01. PMID: 40631228; PMCID: PMC12236793.
      Citations:    
    3. Zheng W, Lowry AJ, Smith HE, Xie J, Rawson S, Wang C, Ou J, Sotomayor M, Fu TM, Yang H, Holt JR. Structural and functional basis of mechanosensitive TMEM63 channelopathies. Neuron. 2025 Aug 06; 113(15):2474-2489.e5. PMID: 40480214; PMCID: PMC12445292.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    4. Lopez DM, Castro CE, Sotomayor M. In silico analyses of molecular force sensors for mechanical characterization of biological systems. Biophys J. 2025 Mar 04; 124(5):829-843. PMID: 39905731; PMCID: PMC11897771.
      Citations:    Fields:    Translation:Cells
    5. Giese APJ, Weng WH, Kindt KS, Chang HHV, Montgomery JS, Ratzan EM, Beirl AJ, Aponte Rivera R, Lotthammer JM, Walujkar S, Foster MP, Zobeiri OA, Holt JR, Riazuddin S, Cullen KE, Sotomayor M, Ahmed ZM. Complexes of vertebrate TMC1/2 and CIB2/3 proteins form hair-cell mechanotransduction cation channels. Elife. 2025 Jan 08; 12. PMID: 39773557; PMCID: PMC11709434.
      Citations: 17     Fields:    Translation:AnimalsCells
    6. Ebrahim S, Ballesteros A, Zheng WS, Mukherjee S, Hu G, Weng WH, Montgomery JS, Agyemang Y, Cui R, Sun W, Krystofiak E, Foster MP, Sotomayor M, Kachar B. Transmembrane channel-like 4 and 5 proteins at microvillar tips are potential ion channels and lipid scramblases. bioRxiv. 2024 Aug 23. PMID: 39229161; PMCID: PMC11370596.
      Citations:    
    7. Lopez DM, Castro CE, Sotomayor M. In-Silico Analyses of Molecular Force Sensors for Mechanical Characterization of Biological Systems. bioRxiv. 2024 Jul 22. PMID: 39091752; PMCID: PMC11291006.
      Citations:    
    8. Giese APJ, Weng WH, Kindt KS, Chang HHV, Montgomery JS, Ratzan EM, Beirl AJ, Rivera RA, Lotthammer JM, Walujkar S, Foster MP, Zobeiri OA, Holt JR, Riazuddin S, Cullen KE, Sotomayor M, Ahmed ZM. Complexes of vertebrate TMC1/2 and CIB2/3 proteins form hair-cell mechanotransduction cation channels. bioRxiv. 2024 Jul 05. PMID: 37398045; PMCID: PMC10312449.
      Citations: 1     
    9. Wen H, Brower J, Martínez-Pérez K, Narui Y, Yeh F, Hale E, Ivanchenko MV, Corey DP, Sotomayor M, Indzhykulian AA. Elasticity and Thermal Stability are Key Determinants of Hearing Rescue by Mini-Protocadherin-15 Proteins. bioRxiv. 2024 Jun 17. PMID: 38948700; PMCID: PMC11212938.
      Citations:    
    10. Tamilselvan E, Sotomayor M. CELSR1, a core planar cell polarity protein, features a weakly adhesive and flexible cadherin ectodomain. Structure. 2024 04 04; 32(4):476-491.e5. PMID: 38307021.
      Citations: 1     Fields:    Translation:HumansCells
    11. Zheng W, Rawson S, Shen Z, Tamilselvan E, Smith HE, Halford J, Shen C, Murthy SE, Ulbrich MH, Sotomayor M, Fu TM, Holt JR. TMEM63 proteins function as monomeric high-threshold mechanosensitive ion channels. Neuron. 2023 10 18; 111(20):3195-3210.e7. PMID: 37543036; PMCID: PMC10592209.
      Citations: 40     Fields:    Translation:Animals
    12. Nisler CR, Narui Y, Scheib E, Choudhary D, Bowman JD, Mandayam Bharathi H, Lynch VJ, Sotomayor M. Interpreting the Evolutionary Echoes of a Protein Complex Essential for Inner-Ear Mechanosensation. Mol Biol Evol. 2023 04 04; 40(4). PMID: 36911992; PMCID: PMC10089651.
      Citations: 1     Fields:    Translation:Animals
    13. Neel BL, Nisler CR, Walujkar S, Araya-Secchi R, Sotomayor M. Elastic versus brittle mechanical responses predicted for dimeric cadherin complexes. Biophys J. 2022 03 15; 121(6):1013-1028. PMID: 35151631; PMCID: PMC8943749.
      Citations: 4     Fields:    Translation:Cells
    14. Neel BL, Nisler CR, Walujkar S, Araya-Secchi R, Sotomayor M. Collective mechanical responses of cadherin-based adhesive junctions as predicted by simulations. Biophys J. 2022 03 15; 121(6):991-1012. PMID: 35150618; PMCID: PMC8943820.
      Citations: 5     Fields:    Translation:Cells
    15. Chen Y, Sotomayor M, Capponi S, Hariharan B, Sahu ID, Haase M, Lorigan GA, Kuhn A, White SH, Dalbey RE. A hydrophilic microenvironment in the substrate-translocating groove of the YidC membrane insertase is essential for enzyme function. J Biol Chem. 2022 03; 298(3):101690. PMID: 35148995; PMCID: PMC8920935.
      Citations: 7     Fields:    Translation:Cells
    16. Gray ME, Johnson ZR, Modak D, Tamilselvan E, Tyska MJ, Sotomayor M. Heterophilic and homophilic cadherin interactions in intestinal intermicrovillar links are species dependent. PLoS Biol. 2021 12; 19(12):e3001463. PMID: 34871294; PMCID: PMC8691648.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    17. Hudson JD, Tamilselvan E, Sotomayor M, Cooper SR. A complete Protocadherin-19 ectodomain model for evaluating epilepsy-causing mutations and potential protein interaction sites. Structure. 2021 10 07; 29(10):1128-1143.e4. PMID: 34520737.
      Citations: 4     Fields:    Translation:HumansCells
    18. Ahmed T, Nisler CR, Fluck EC, Walujkar S, Sotomayor M, Moiseenkova-Bell VY. Structure of the ancient TRPY1 channel from Saccharomyces cerevisiae reveals mechanisms of modulation by lipids and calcium. Structure. 2022 01 06; 30(1):139-155.e5. PMID: 34453887; PMCID: PMC8741645.
      Citations: 10     Fields:    Translation:AnimalsCells
    19. Caldwell BJ, Norris A, Zakharova E, Smith CE, Wheat CT, Choudhary D, Sotomayor M, Wysocki VH, Bell CE. Oligomeric complexes formed by Redß single strand annealing protein in its different DNA bound states. Nucleic Acids Res. 2021 04 06; 49(6):3441-3460. PMID: 33693865; PMCID: PMC8034648.
      Citations: 8     Fields:    Translation:Cells
    20. Smith H, Pinkerton N, Heisler DB, Kudryashova E, Hall AR, Karch KR, Norris A, Wysocki V, Sotomayor M, Reisler E, Vavylonis D, Kudryashov DS. Rounding Out the Understanding of ACD Toxicity with the Discovery of Cyclic Forms of Actin Oligomers. Int J Mol Sci. 2021 Jan 13; 22(2). PMID: 33450834; PMCID: PMC7828245.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    21. Choudhary D, Narui Y, Neel BL, Wimalasena LN, Klanseck CF, De-la-Torre P, Chen C, Araya-Secchi R, Tamilselvan E, Sotomayor M. Structural determinants of protocadherin-15 mechanics and function in hearing and balance perception. Proc Natl Acad Sci U S A. 2020 10 06; 117(40):24837-24848. PMID: 32963095; PMCID: PMC7547225.
      Citations: 27     Fields:    Translation:HumansCells
    22. Park MS, Araya-Secchi R, Brackbill JA, Phan HD, Kehling AC, Abd El-Wahab EW, Dayeh DM, Sotomayor M, Nakanishi K. Multidomain Convergence of Argonaute during RISC Assembly Correlates with the Formation of Internal Water Clusters. Mol Cell. 2019 08 22; 75(4):725-740.e6. PMID: 31324450; PMCID: PMC6707842.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    23. De-la-Torre P, Choudhary D, Araya-Secchi R, Narui Y, Sotomayor M. A Mechanically Weak Extracellular Membrane-Adjacent Domain Induces Dimerization of Protocadherin-15. Biophys J. 2018 12 18; 115(12):2368-2385. PMID: 30527337; PMCID: PMC6302040.
      Citations: 18     Fields:    Translation:AnimalsCells
    24. Chen TH, Sotomayor M, Gopalan V. Biochemical Studies Provide Insights into the Necessity for Multiple Arabidopsis thaliana Protein-Only RNase P Isoenzymes. J Mol Biol. 2019 02 01; 431(3):615-624. PMID: 30414965; PMCID: PMC6349523.
      Citations: 5     Fields:    Translation:AnimalsCells
    25. Pan B, Akyuz N, Liu XP, Asai Y, Nist-Lund C, Kurima K, Derfler BH, György B, Limapichat W, Walujkar S, Wimalasena LN, Sotomayor M, Corey DP, Holt JR. TMC1 Forms the Pore of Mechanosensory Transduction Channels in Vertebrate Inner Ear Hair Cells. Neuron. 2018 08 22; 99(4):736-753.e6. PMID: 30138589; PMCID: PMC6360533.
      Citations: 184     Fields:    Translation:HumansAnimalsCells
    26. Jaiganesh A, De-la-Torre P, Patel AA, Termine DJ, Velez-Cortes F, Chen C, Sotomayor M. Zooming in on Cadherin-23: Structural Diversity and Potential Mechanisms of Inherited Deafness. Structure. 2018 09 04; 26(9):1210-1225.e4. PMID: 30033219; PMCID: PMC6375707.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    27. Fecker T, Galaz-Davison P, Engelberger F, Narui Y, Sotomayor M, Parra LP, Ramírez-Sarmiento CA. Active Site Flexibility as a Hallmark for Efficient PET Degradation by I. sakaiensis PETase. Biophys J. 2018 03 27; 114(6):1302-1312. PMID: 29590588; PMCID: PMC5883944.
      Citations: 78     Fields:    Translation:Cells
    28. Powers RE, Gaudet R, Sotomayor M. A Partial Calcium-Free Linker Confers Flexibility to Inner-Ear Protocadherin-15. Structure. 2017 03 07; 25(3):482-495. PMID: 28238533; PMCID: PMC5363953.
      Citations: 18     Fields:    Translation:HumansCells
    29. Sotomayor M, Gaudet R, Corey DP. Sorting out a promiscuous superfamily: towards cadherin connectomics. Trends Cell Biol. 2014 Sep; 24(9):524-36. PMID: 24794279; PMCID: PMC4294768.
      Citations: 48     Fields:    Translation:AnimalsCells
    30. Koussa MA, Sotomayor M, Wong WP. Protocol for sortase-mediated construction of DNA-protein hybrids and functional nanostructures. Methods. 2014 May 15; 67(2):134-41. PMID: 24568941; PMCID: PMC4312557.
      Citations: 16     Fields:    Translation:Cells
    31. Gamini R, Sotomayor M, Chipot C, Schulten K. Cytoplasmic domain filter function in the mechanosensitive channel of small conductance. Biophys J. 2011 Jul 06; 101(1):80-9. PMID: 21723817; PMCID: PMC3127185.
      Citations: 16     Fields:    Translation:Cells
    32. Sotomayor M, Schulten K. The allosteric role of the Ca2+ switch in adhesion and elasticity of C-cadherin. Biophys J. 2008 Jun; 94(12):4621-33. PMID: 18326636; PMCID: PMC2397358.
      Citations: 79     Fields:    Translation:Cells
    33. Sotomayor M, Perozo E, Schulten K, Vásquez V. Ion conduction through MscS as determined by electrophysiology and simulation. Biophys J. 2007 Feb 01; 92(3):886-902. PMID: 17114233; PMCID: PMC1779981.
      Citations: 70     Fields:    Translation:Cells
    34. Sotomayor M, van der Straaten TA, Ravaioli U, Schulten K. Electrostatic properties of the mechanosensitive channel of small conductance MscS. Biophys J. 2006 May 15; 90(10):3496-510. PMID: 16513774; PMCID: PMC1440732.
      Citations: 27     Fields:    Translation:Cells
    35. Sotomayor M, Schulten K. Molecular dynamics study of gating in the mechanosensitive channel of small conductance MscS. Biophys J. 2004 Nov; 87(5):3050-65. PMID: 15339798; PMCID: PMC1304777.
      Citations: 80     Fields:    Translation:Cells
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