 Mechlorethamine
"Mechlorethamine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A vesicant and necrotizing irritant destructive to mucous membranes. It was formerly used as a war gas. The hydrochloride is used as an antineoplastic in Hodgkin's disease and lymphomas. It causes severe gastrointestinal and bone marrow damage.
| Descriptor ID |
D008466
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| MeSH Number(s) |
D02.455.526.728.650.529
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| Concept/Terms |
Mechlorethamine- Mechlorethamine
- Chlorethazine
- Chlormethine
- Mustine
- Nitrogen Mustard
- Bis(2-chloroethyl)methylamine
- Methylchlorethamine
Mechlorethamine Hydrochloride N-Oxide- Mechlorethamine Hydrochloride N-Oxide
- Hydrochloride N-Oxide, Mechlorethamine
- Mechlorethamine Hydrochloride N Oxide
- N-Oxide, Mechlorethamine Hydrochloride
Mustargen- Mustargen
- Merck Frosst Brand of Mechlorethamine Hydrochloride
- Merck Brand of Mechlorethamine Hydrochloride
Caryolysine- Caryolysine
- Genopharm Brand of Mechlorethamine Hydrochloride
Mechlorethamine N-Oxide- Mechlorethamine N-Oxide
- Mechlorethamine N Oxide
- N-Oxide, Mechlorethamine
- Nitrogen Mustard N-Oxide
- N-Oxide, Nitrogen Mustard
- Nitrogen Mustard N Oxide
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Below are MeSH descriptors whose meaning is more general than "Mechlorethamine".
Below are MeSH descriptors whose meaning is more specific than "Mechlorethamine".
This graph shows the total number of publications written about "Mechlorethamine" by people in this website by year, and whether "Mechlorethamine" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1980 | 0 | 1 | 1 | | 1981 | 0 | 1 | 1 | | 1986 | 1 | 0 | 1 | | 1988 | 0 | 1 | 1 | | 1998 | 1 | 1 | 2 |
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Below are the most recent publications written about "Mechlorethamine" by people in Profiles.
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Lamb PM, Menaker GM, Moy RL. Multiple basal cell carcinomas of the limb after adjuvant treatment of melanoma with isolated limb perfusion. J Am Acad Dermatol. 1998 May; 38(5 Pt 1):767-8.
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Glick JH, Young ML, Harrington D, Schilsky RL, Beck T, Neiman R, Fisher RI, Peterson BA, Oken MM. MOPP/ABV hybrid chemotherapy for advanced Hodgkin's disease significantly improves failure-free and overall survival: the 8-year results of the intergroup trial. J Clin Oncol. 1998 Jan; 16(1):19-26.
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Hallahan DE, Griem ML, Griem SF, Medenica M, Soltani K, Lorincz AL, Baron JM. Combined modality therapy for tumor stage mycosis fungoides: results of a 10-year follow-up. J Clin Oncol. 1988 Jul; 6(7):1177-83.
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Sagher D, Karrison T, Schwartz JL, Larson R, Meier P, Strauss B. Low O6-alkylguanine DNA alkyltransferase activity in the peripheral blood lymphocytes of patients with therapy-related acute nonlymphocytic leukemia. Cancer Res. 1988 Jun 01; 48(11):3084-9.
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Nagy B, Grdina DJ. Protective effects of 2-[(aminopropyl)amino] ethanethiol against bleomycin and nitrogen mustard-induced mutagenicity in V79 cells. Int J Radiat Oncol Biol Phys. 1986 Aug; 12(8):1475-8.
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Schilsky RL, Sherins RJ, Hubbard SM, Wesley MN, Young RC, DeVita VT. Long-term follow up of ovarian function in women treated with MOPP chemotherapy for Hodgkin's disease. Am J Med. 1981 Oct; 71(4):552-6.
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Golomb HM, Sweet DL. Diagnosis, staging, and treatment of the malignant lymphomas. Compr Ther. 1980 Jul; 6(7):48-56.
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Greenberger JS, Come SE, Weichselbaum RR. Issues of controversy in radiation therapy and combined modality approaches to Hodgkin's disease. Clin Haematol. 1979 Oct; 8(3):611-24.
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Abelson HT, Karlan D, Penman S. A comparison of the effects of alkylating agents 1,3-bis(2-chloroethyl)-1-nitrosourea, 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea and nitrogen mustard on nuclear RNA synthesis and processing. Biochim Biophys Acta. 1974 May 31; 349(3):389-401.
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Helman P, Sealy R, Malherbe E, Anderson J. Intra-arterial cytotoxic therapy and x-ray therapy for cancer of the head and neck. Lancet. 1965 Jan 16; 1(7377):128-30.
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