 Ribose-Phosphate Pyrophosphokinase
"Ribose-Phosphate Pyrophosphokinase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the formation of phosphoribosyl pyrophosphate from ATP and ribose-5-phosphate. EC 2.7.6.1.
| Descriptor ID |
D012268
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| MeSH Number(s) |
D08.811.913.696.175.650
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| Concept/Terms |
Ribose-Phosphate Pyrophosphokinase- Ribose-Phosphate Pyrophosphokinase
- Pyrophosphokinase, Ribose-Phosphate
- Ribose Phosphate Pyrophosphokinase
- PRPP Synthetase
- Synthetase, PRPP
- PRibPP Synthetase
- Ribosephosphate Pyrophosphokinase
- Pyrophosphokinase, Ribosephosphate
- 5-Phospho-alpha-D-Ribose 1-Diphosphate Synthetase
- 1-Diphosphate Synthetase, 5-Phospho-alpha-D-Ribose
- 5 Phospho alpha D Ribose 1 Diphosphate Synthetase
- Synthetase, 5-Phospho-alpha-D-Ribose 1-Diphosphate
- Phosphoribosyl Pyrophosphate Synthetase
- Pyrophosphate Synthetase, Phosphoribosyl
- Synthetase, Phosphoribosyl Pyrophosphate
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Below are MeSH descriptors whose meaning is more general than "Ribose-Phosphate Pyrophosphokinase".
Below are MeSH descriptors whose meaning is more specific than "Ribose-Phosphate Pyrophosphokinase".
This graph shows the total number of publications written about "Ribose-Phosphate Pyrophosphokinase" by people in this website by year, and whether "Ribose-Phosphate Pyrophosphokinase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
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| 1980 | 2 | 0 | 2 | | 1981 | 1 | 1 | 2 | | 1982 | 1 | 0 | 1 | | 1983 | 0 | 1 | 1 | | 1984 | 5 | 1 | 6 | | 1985 | 1 | 0 | 1 | | 1986 | 4 | 0 | 4 | | 1987 | 1 | 1 | 2 | | 1989 | 3 | 0 | 3 | | 1990 | 1 | 0 | 1 | | 1991 | 2 | 0 | 2 | | 1992 | 2 | 0 | 2 | | 1993 | 2 | 0 | 2 | | 1994 | 3 | 0 | 3 | | 1995 | 2 | 0 | 2 | | 1996 | 2 | 0 | 2 | | 1998 | 1 | 0 | 1 | | 1999 | 1 | 0 | 1 | | 2000 | 1 | 0 | 1 | | 2001 | 1 | 0 | 1 | | 2003 | 1 | 0 | 1 |
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Below are the most recent publications written about "Ribose-Phosphate Pyrophosphokinase" by people in Profiles.
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García-Pavía P, Torres RJ, Rivero M, Ahmed M, García-Puig J, Becker MA. Phosphoribosylpyrophosphate synthetase overactivity as a cause of uric acid overproduction in a young woman. Arthritis Rheum. 2003 Jul; 48(7):2036-41.
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Becker MA. Phosphoribosylpyrophosphate synthetase and the regulation of phosphoribosylpyrophosphate production in human cells. Prog Nucleic Acid Res Mol Biol. 2001; 69:115-48.
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Becker MA, Ahmed M. Cell type-specific differential expression of human PRPP synthetase (PRPS) genes. Adv Exp Med Biol. 2000; 486:5-10.
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Ahmed M, Taylor W, Smith PR, Becker MA. Accelerated transcription of PRPS1 in X-linked overactivity of normal human phosphoribosylpyrophosphate synthetase. J Biol Chem. 1999 Mar 12; 274(11):7482-8.
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Becker MA, Taylor W, Smith PR, Ahmed M. Regulation of human PRS isoform expression. Adv Exp Med Biol. 1998; 431:215-20.
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Becker MA, Taylor W, Smith PR, Ahmed M. Overexpression of the normal phosphoribosylpyrophosphate synthetase 1 isoform underlies catalytic superactivity of human phosphoribosylpyrophosphate synthetase. J Biol Chem. 1996 Aug 16; 271(33):19894-9.
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Torres RJ, Mateos FA, Puig JG, Becker MA. Determination of phosphoribosylpyrophosphate synthetase activity in human cells by a non-isotopic, one step method. Clin Chim Acta. 1996 Feb 09; 245(1):105-12.
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Becker MA, Smith PR, Taylor W, Mustafi R, Switzer RL. The genetic and functional basis of purine nucleotide feedback-resistant phosphoribosylpyrophosphate synthetase superactivity. J Clin Invest. 1995 Nov; 96(5):2133-41.
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Fry DW, Becker MA, Switzer RL. Inhibition of human 5-phosphoribosyl-1-pyrophosphate synthetase by 4-amino-8-(beta-D-ribofuranosylamino)-pyrimido[5,4-d]pyrimidine-5'- monophosphate: evidence for interaction at the ADP allosteric site. Mol Pharmacol. 1995 Apr; 47(4):810-5.
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Torres RJ, Mateos FA, Puig JG, Becker MA. A simplified method for the determination of phosphoribosylpyrophosphate synthetase activity in hemolysates. Clin Chim Acta. 1994 Jan 14; 224(1):55-63.
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