"Ketamine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.
| Descriptor ID |
D007649
|
| MeSH Number(s) |
D02.455.426.392.368.367.652
|
| Concept/Terms |
Ketamine- Ketamine
- 2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone
|
Below are MeSH descriptors whose meaning is more general than "Ketamine".
Below are MeSH descriptors whose meaning is more specific than "Ketamine".
This graph shows the total number of publications written about "Ketamine" by people in this website by year, and whether "Ketamine" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 2 | 2 |
| 2005 | 1 | 0 | 1 |
| 2008 | 3 | 1 | 4 |
| 2009 | 1 | 1 | 2 |
| 2011 | 1 | 0 | 1 |
| 2012 | 1 | 0 | 1 |
| 2013 | 1 | 1 | 2 |
| 2015 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
| 2018 | 2 | 0 | 2 |
| 2020 | 3 | 0 | 3 |
| 2021 | 1 | 0 | 1 |
| 2022 | 1 | 0 | 1 |
| 2023 | 1 | 0 | 1 |
| 2024 | 2 | 0 | 2 |
| 2025 | 1 | 1 | 2 |
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Below are the most recent publications written about "Ketamine" by people in Profiles.
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Rapid antidepressant potential of nitrous oxide: current state and major questions. Mol Psychiatry. 2026 Jun; 31(6):3022-3032.
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Ketamine or Etomidate for Tracheal Intubation of Critically Ill Adults. N Engl J Med. 2026 Apr 23; 394(16):1608-1620.
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Ketamine Versus Etomidate for Rapid Sequence Intubation: A Systematic Review and Meta-Analysis of Randomized Trials. Crit Care Med. 2025 Feb 01; 53(2):e374-e383.
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Ketamine's rapid and sustained antidepressant effects are driven by distinct mechanisms. Cell Mol Life Sci. 2024 Feb 27; 81(1):105.
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Nitrous Oxide Reduced Suicidal Ideation in Treatment-Resistant Major Depression in Exploratory Analysis. J Clin Psychiatry. 2023 08 16; 84(5).
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Nitrous Oxide, a Rapid Antidepressant, Has Ketamine-like Effects on Excitatory Transmission in the Adult Hippocampus. Biol Psychiatry. 2022 12 15; 92(12):964-972.
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Synergistic Effect of Ketamine and Buprenorphine Observed in the Treatment of Buprenorphine Precipitated Opioid Withdrawal in a Patient With Fentanyl Use. J Addict Med. 2022 Jul-Aug 01; 16(4):483-487.
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Perioperative Methadone and Ketamine for Postoperative Pain Control in Spinal Surgical Patients: A Randomized, Double-blind, Placebo-controlled Trial. Anesthesiology. 2021 05 01; 134(5):697-708.
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Ketamine infusion reduces narcotic requirements following gastric bypass surgery: a randomized controlled trial. Surg Obes Relat Dis. 2021 Apr; 17(4):737-743.
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Ketamine and nitrous oxide: The evolution of NMDA receptor antagonists as antidepressant agents. J Neurol Sci. 2020 05 15; 412:116778.