"Picrotoxin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A noncompetitive antagonist at GABA-A receptors and thus a convulsant. Picrotoxin blocks the GAMMA-AMINOBUTYRIC ACID-activated chloride ionophore. Although it is most often used as a research tool, it has been used as a CNS stimulant and an antidote in poisoning by CNS depressants, especially the barbiturates.
| Descriptor ID |
D010852
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| MeSH Number(s) |
D02.455.426.392.368.367.800 D02.540.552
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Picrotoxin".
Below are MeSH descriptors whose meaning is more specific than "Picrotoxin".
This graph shows the total number of publications written about "Picrotoxin" by people in this website by year, and whether "Picrotoxin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 0 | 1 | 1 |
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Picrotoxin" by people in Profiles.
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Functional Deficiency of Interneurons and Negative BOLD fMRI Response. Cells. 2023 03 06; 12(5).
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Repeated binge-like ethanol drinking alters ethanol drinking patterns and depresses striatal GABAergic transmission. Neuropsychopharmacology. 2014 Feb; 39(3):579-94.
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Glyoxalase 1 and its substrate methylglyoxal are novel regulators of seizure susceptibility. Epilepsia. 2013 Apr; 54(4):649-57.
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Hydrogen peroxide differentially affects activity in the pre-Bötzinger complex and hippocampus. J Neurophysiol. 2011 Dec; 106(6):3045-55.
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Maturation of cultured hippocampal slices results in increased excitability in granule cells. Int J Dev Neurosci. 2005 Feb; 23(1):65-73.
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Subunit composition and function of GABAA receptors of rat spermatozoa. Neurochem Res. 2002 Mar; 27(3):195-9.
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Abnormal GABAA receptor-mediated currents in dorsal root ganglion neurons isolated from Na-K-2Cl cotransporter null mice. J Neurosci. 2000 Oct 15; 20(20):7531-8.
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Ions required for the electrogenic transport of GABA by horizontal cells of the catfish retina. J Physiol. 1993 Dec; 472:81-102.