"Ligands" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A molecule that binds to another molecule, used especially to refer to a small molecule that binds specifically to a larger molecule, e.g., an antigen binding to an antibody, a hormone or neurotransmitter binding to a receptor, or a substrate or allosteric effector binding to an enzyme. Ligands are also molecules that donate or accept a pair of electrons to form a coordinate covalent bond with the central metal atom of a coordination complex. (From Dorland, 27th ed)
| Descriptor ID |
D008024
|
| MeSH Number(s) |
D27.720.470.480
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Ligands".
Below are MeSH descriptors whose meaning is more specific than "Ligands".
This graph shows the total number of publications written about "Ligands" by people in this website by year, and whether "Ligands" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 3 | 3 |
| 1996 | 0 | 6 | 6 |
| 1997 | 0 | 8 | 8 |
| 1998 | 1 | 6 | 7 |
| 1999 | 0 | 7 | 7 |
| 2000 | 0 | 9 | 9 |
| 2001 | 0 | 10 | 10 |
| 2002 | 0 | 15 | 15 |
| 2003 | 0 | 21 | 21 |
| 2004 | 0 | 13 | 13 |
| 2005 | 2 | 14 | 16 |
| 2006 | 1 | 12 | 13 |
| 2007 | 0 | 17 | 17 |
| 2008 | 0 | 12 | 12 |
| 2009 | 1 | 21 | 22 |
| 2010 | 1 | 9 | 10 |
| 2011 | 0 | 7 | 7 |
| 2012 | 2 | 19 | 21 |
| 2013 | 0 | 11 | 11 |
| 2014 | 0 | 13 | 13 |
| 2015 | 0 | 13 | 13 |
| 2016 | 0 | 12 | 12 |
| 2017 | 1 | 11 | 12 |
| 2018 | 0 | 12 | 12 |
| 2019 | 0 | 8 | 8 |
| 2020 | 1 | 17 | 18 |
| 2021 | 0 | 8 | 8 |
| 2022 | 0 | 17 | 17 |
| 2023 | 0 | 12 | 12 |
| 2024 | 0 | 7 | 7 |
| 2025 | 0 | 1 | 1 |
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Below are the most recent publications written about "Ligands" by people in Profiles.
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Accurate Physics-Based Prediction of Binding Affinities of RNA- and DNA-Targeting Ligands. J Chem Inf Model. 2025 Feb 10; 65(3):1392-1403.
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Nanoscale Mixed-Ligand Metal-Organic Framework for X-ray Stimulated Cancer Therapy. J Am Chem Soc. 2024 Dec 04; 146(48):33149-33158.
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A Method for Treating Significant Conformational Changes in Alchemical Free Energy Simulations of Protein-Ligand Binding. J Chem Theory Comput. 2024 Oct 08; 20(19):8609-8623.
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Ligand-induced segregation from large cell-surface phosphatases is a critical step in ?d TCR triggering. Cell Rep. 2024 09 24; 43(9):114761.
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Signaling Ligand Heterogeneities in the Peduncle Complex of the Cephalopod Mollusc Octopus bimaculoides. Brain Behav Evol. 2024; 99(3):158-170.
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Metabolic trade-offs in Neonatal sepsis triggered by TLR4 and TLR1/2 ligands result in unique dysfunctions in neural breathing circuits. Brain Behav Immun. 2024 Jul; 119:333-350.
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Delivery of loaded MR1 monomer results in efficient ligand exchange to host MR1 and subsequent MR1T cell activation. Commun Biol. 2024 02 24; 7(1):228.
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Immunogenic Bifunctional Nanoparticle Suppresses Programmed Cell Death-Ligand 1 in Cancer and Dendritic Cells to Enhance Adaptive Immunity and Chemo-Immunotherapy. ACS Nano. 2024 02 13; 18(6):5152-5166.
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Effect of Ziltivekimab on Determinants of Hemoglobin in Patients with CKD Stage 3-5: An Analysis of a Randomized Trial (RESCUE). J Am Soc Nephrol. 2024 01 01; 35(1):74-84.
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Potential Dietary and Therapeutic Strategies Involving Indole-3-Carbinole in Preclinical Models of Intestinal Inflammation. Nutrients. 2023 Nov 30; 15(23).