 Ligands
"Ligands" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A molecule that binds to another molecule, used especially to refer to a small molecule that binds specifically to a larger molecule, e.g., an antigen binding to an antibody, a hormone or neurotransmitter binding to a receptor, or a substrate or allosteric effector binding to an enzyme. Ligands are also molecules that donate or accept a pair of electrons to form a coordinate covalent bond with the central metal atom of a coordination complex. (From Dorland, 27th ed)
| Descriptor ID |
D008024
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| MeSH Number(s) |
D27.720.470.480
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Ligands".
Below are MeSH descriptors whose meaning is more specific than "Ligands".
This graph shows the total number of publications written about "Ligands" by people in this website by year, and whether "Ligands" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1984 | 0 | 1 | 1 | | 1986 | 0 | 1 | 1 | | 1987 | 0 | 1 | 1 | | 1988 | 0 | 2 | 2 | | 1989 | 0 | 2 | 2 | | 1990 | 0 | 1 | 1 | | 1993 | 0 | 1 | 1 | | 1994 | 0 | 4 | 4 | | 1995 | 0 | 4 | 4 | | 1996 | 0 | 6 | 6 | | 1997 | 0 | 9 | 9 | | 1998 | 1 | 7 | 8 | | 1999 | 0 | 7 | 7 | | 2000 | 0 | 8 | 8 | | 2001 | 0 | 10 | 10 | | 2002 | 0 | 16 | 16 | | 2003 | 0 | 22 | 22 | | 2004 | 0 | 13 | 13 | | 2005 | 2 | 14 | 16 | | 2006 | 0 | 13 | 13 | | 2007 | 0 | 20 | 20 | | 2008 | 0 | 13 | 13 | | 2009 | 1 | 22 | 23 | | 2010 | 1 | 10 | 11 | | 2011 | 0 | 10 | 10 | | 2012 | 2 | 16 | 18 | | 2013 | 0 | 11 | 11 | | 2014 | 0 | 12 | 12 | | 2015 | 0 | 14 | 14 | | 2016 | 0 | 12 | 12 | | 2017 | 1 | 10 | 11 | | 2018 | 0 | 11 | 11 | | 2019 | 0 | 8 | 8 | | 2020 | 1 | 15 | 16 | | 2021 | 0 | 4 | 4 |
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Below are the most recent publications written about "Ligands" by people in Profiles.
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Klawon DEJ, Gilmore DC, Leonard JD, Miller CH, Chao JL, Walker MT, Duncombe RK, Tung KS, Adams EJ, Savage PA. Altered selection on a single self-ligand promotes susceptibility to organ-specific T cell infiltration. J Exp Med. 2021 06 07; 218(6).
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Michalska K, Jedrzejczak R, Wower J, Chang C, Baragaña B, Gilbert IH, Forte B, Joachimiak A. Mycobacterium tuberculosis Phe-tRNA synthetase: structural insights into tRNA recognition and aminoacylation. Nucleic Acids Res. 2021 05 21; 49(9):5351-5368.
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Kim Y, Wower J, Maltseva N, Chang C, Jedrzejczak R, Wilamowski M, Kang S, Nicolaescu V, Randall G, Michalska K, Joachimiak A. Tipiracil binds to uridine site and inhibits Nsp15 endoribonuclease NendoU from SARS-CoV-2. Commun Biol. 2021 02 09; 4(1):193.
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Kimani FW, Ajit J, Galluppi A, Manna S, Howitz WJ, Tang S, Esser-Kahn AP. Receptor-Ligand Kinetics Influence the Mechanism of Action of Covalently Linked TLR Ligands. ACS Chem Biol. 2021 02 19; 16(2):380-388.
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Hochberg GKA, Liu Y, Marklund EG, Metzger BPH, Laganowsky A, Thornton JW. A hydrophobic ratchet entrenches molecular complexes. Nature. 2020 12; 588(7838):503-508.
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Pergola PE, Devalaraja M, Fishbane S, Chonchol M, Mathur VS, Smith MT, Lo L, Herzog K, Kakkar R, Davidson MH. Ziltivekimab for Treatment of Anemia of Inflammation in Patients on Hemodialysis: Results from a Phase 1/2 Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial. J Am Soc Nephrol. 2021 01; 32(1):211-222.
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Abderrahman B, Maximov PY, Curpan RF, Fanning SW, Hanspal JS, Fan P, Foulds CE, Chen Y, Malovannaya A, Jain A, Xiong R, Greene GL, Tonetti DA, Thatcher GRJ, Jordan VC. Rapid Induction of the Unfolded Protein Response and Apoptosis by Estrogen Mimic TTC-352 for the Treatment of Endocrine-Resistant Breast Cancer. Mol Cancer Ther. 2021 01; 20(1):11-25.
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Somani S, Jo S, Thirumangalathu R, Rodrigues D, Tanenbaum LM, Amin K, MacKerell AD, Thakkar SV. Toward Biotherapeutics Formulation Composition Engineering using Site-Identification by Ligand Competitive Saturation (SILCS). J Pharm Sci. 2021 03; 110(3):1103-1110.
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Basak S, Kumar A, Ramsey S, Gibbs E, Kapoor A, Filizola M, Chakrapani S. High-resolution structures of multiple 5-HT3AR-setron complexes reveal a novel mechanism of competitive inhibition. Elife. 2020 10 16; 9.
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Dajnowicz S, Ghoreishi D, Modugula K, Damm W, Harder ED, Abel R, Wang L, Yu HS. Advancing Free-Energy Calculations of Metalloenzymes in Drug Discovery via Implementation of LFMM Potentials. J Chem Theory Comput. 2020 Nov 10; 16(11):6926-6937.
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