 Persistent Fetal Circulation Syndrome
"Persistent Fetal Circulation Syndrome" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A syndrome of persistent PULMONARY HYPERTENSION in the newborn infant (INFANT, NEWBORN) without demonstrable HEART DISEASES. This neonatal condition can be caused by severe pulmonary vasoconstriction (reactive type), hypertrophy of pulmonary arterial muscle (hypertrophic type), or abnormally developed pulmonary arterioles (hypoplastic type). The newborn patient exhibits CYANOSIS and ACIDOSIS due to the persistence of fetal circulatory pattern of right-to-left shunting of blood through a patent ductus arteriosus (DUCTUS ARTERIOSUS, PATENT) and at times a patent foramen ovale (FORAMEN OVALE, PATENT).
| Descriptor ID |
D010547
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| MeSH Number(s) |
C08.381.423.694 C16.614.694
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| Concept/Terms |
Persistent Fetal Circulation Syndrome- Persistent Fetal Circulation Syndrome
- Fetal Circulation, Persistent
- Pulmonary Hypertension, Familial Persistent, of the Newborn
- Persistent Fetal Circulation
- Persistent Pulmonary Hypertension of Newborn
- Circulation, Persistent Fetal
- Hypertension, Pulmonary, of Newborn, Persistent
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Below are MeSH descriptors whose meaning is more general than "Persistent Fetal Circulation Syndrome".
Below are MeSH descriptors whose meaning is more specific than "Persistent Fetal Circulation Syndrome".
This graph shows the total number of publications written about "Persistent Fetal Circulation Syndrome" by people in this website by year, and whether "Persistent Fetal Circulation Syndrome" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1986 | 1 | 0 | 1 | | 1997 | 1 | 0 | 1 | | 2002 | 0 | 1 | 1 | | 2008 | 0 | 1 | 1 | | 2015 | 0 | 1 | 1 | | 2018 | 1 | 0 | 1 |
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Below are the most recent publications written about "Persistent Fetal Circulation Syndrome" by people in Profiles.
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Suzuki S, Togari H, Potenziano JL, Schreiber MD. Efficacy of inhaled nitric oxide in neonates with hypoxic respiratory failure and pulmonary hypertension: the Japanese experience. J Perinat Med. 2018 Aug 28; 46(6):657-663.
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Abman SH, Hansmann G, Archer SL, Ivy DD, Adatia I, Chung WK, Hanna BD, Rosenzweig EB, Raj JU, Cornfield D, Stenmark KR, Steinhorn R, Thébaud B, Fineman JR, Kuehne T, Feinstein JA, Friedberg MK, Earing M, Barst RJ, Keller RL, Kinsella JP, Mullen M, Deterding R, Kulik T, Mallory G, Humpl T, Wessel DL. Pediatric Pulmonary Hypertension: Guidelines From the American Heart Association and American Thoracic Society. Circulation. 2015 Nov 24; 132(21):2037-99.
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Wedgwood S, Lakshminrusimha S, Schumacker PT, Steinhorn RH. Cyclic stretch stimulates mitochondrial reactive oxygen species and Nox4 signaling in pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2015 Jul 15; 309(2):L196-203.
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Wedgwood S, Lakshminrusimha S, Fukai T, Russell JA, Schumacker PT, Steinhorn RH. Hydrogen peroxide regulates extracellular superoxide dismutase activity and expression in neonatal pulmonary hypertension. Antioxid Redox Signal. 2011 Sep 15; 15(6):1497-506.
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Farrow KN, Wedgwood S, Lee KJ, Czech L, Gugino SF, Lakshminrusimha S, Schumacker PT, Steinhorn RH. Mitochondrial oxidant stress increases PDE5 activity in persistent pulmonary hypertension of the newborn. Respir Physiol Neurobiol. 2010 Dec 31; 174(3):272-81.
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Bin-Nun A, Schreiber MD. Role of iNO in the modulation of pulmonary vascular resistance. J Perinatol. 2008 Dec; 28 Suppl 3:S84-92.
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Schreiber MD, Dixit R, Rudinsky B, Hipps R, Morgan SE, Keith RRT A, Meadow W. Direct comparison of the effects of nebulized nitroprusside versus inhaled nitric oxide on pulmonary and systemic hemodynamics during hypoxia-induced pulmonary hypertension in piglets. Crit Care Med. 2002 Nov; 30(11):2560-5.
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Roberts JD, Fineman JR, Morin FC, Shaul PW, Rimar S, Schreiber MD, Polin RA, Zwass MS, Zayek MM, Gross I, Heymann MA, Zapol WM. Inhaled nitric oxide and persistent pulmonary hypertension of the newborn. The Inhaled Nitric Oxide Study Group. N Engl J Med. 1997 Feb 27; 336(9):605-10.
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Rudinsky BF, Komar KJ, Strates E, Meadow WL. Neither nitroglycerin nor nitroprusside selectively reduces sepsis-induced pulmonary hypertension in piglets. Crit Care Med. 1987 Dec; 15(12):1127-30.
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Meadow W, Benn A, Giardini N, Hageman J, Berger S. Clinical correlates do not predict PaO2 response after tolazoline administration in hypoxic newborns. Crit Care Med. 1986 Jun; 14(6):548-51.
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