"Spiro Compounds" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Cyclic compounds that include two rings which share a single atom (usually a carbon). The simplest example of this type of compound is Spiro[2.2]pentane, which looks like a bow tie.
| Descriptor ID |
D013141
|
| MeSH Number(s) |
D02.455.426.779 D04.711
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Spiro Compounds".
Below are MeSH descriptors whose meaning is more specific than "Spiro Compounds".
This graph shows the total number of publications written about "Spiro Compounds" by people in this website by year, and whether "Spiro Compounds" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2013 | 2 | 0 | 2 |
| 2015 | 3 | 0 | 3 |
| 2016 | 3 | 2 | 5 |
| 2017 | 1 | 1 | 2 |
| 2019 | 2 | 0 | 2 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Spiro Compounds" by people in Profiles.
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Imaging Mitochondrial Hydrogen Peroxide in Living Cells. Methods Mol Biol. 2021; 2275:127-140.
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Ranirestat Improved Nerve Conduction Velocities, Sensory Perception, and Intraepidermal Nerve Fiber Density in Rats with Overt Diabetic Polyneuropathy. J Diabetes Res. 2019; 2019:2756020.
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The safety of rolapitant for the treatment of nausea and vomiting associated with chemotherapy. Expert Opin Drug Saf. 2019 Dec; 18(12):1127-1132.
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Design and synthesis of new substituted spirooxindoles as potential inhibitors of the MDM2-p53 interaction. Bioorg Chem. 2019 05; 86:598-608.
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Synthesis of new thiazolo-pyrrolidine-(spirooxindole) tethered to 3-acylindole as anticancer agents. Bioorg Chem. 2019 02; 82:423-430.
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Recent developments in the clinical pharmacology of rolapitant: subanalyses in specific populations. Drug Des Devel Ther. 2017; 11:2621-2629.
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Pharmacological inhibition of LSD1 and mTOR reduces mitochondrial retention and associated ROS levels in the red blood cells of sickle cell disease. Exp Hematol. 2017 06; 50:46-52.
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Rolapitant improves quality of life of patients receiving highly or moderately emetogenic chemotherapy. Support Care Cancer. 2017 01; 25(1):85-92.
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Therapeutic Inhibition of the MDM2-p53 Interaction Prevents Recurrence of Adenoid Cystic Carcinomas. Clin Cancer Res. 2017 Feb 15; 23(4):1036-1048.
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ADAM17 is a Tumor Promoter and Therapeutic Target in Western Diet-associated Colon Cancer. Clin Cancer Res. 2017 Jan 15; 23(2):549-561.