 Tryptophan
"Tryptophan" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An essential amino acid that is necessary for normal growth in infants and for NITROGEN balance in adults. It is a precursor of INDOLE ALKALOIDS in plants. It is a precursor of SEROTONIN (hence its use as an antidepressant and sleep aid). It can be a precursor to NIACIN, albeit inefficiently, in mammals.
| Descriptor ID |
D014364
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| MeSH Number(s) |
D12.125.072.050.850 D12.125.142.875
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| Concept/Terms |
Tryptophan- Tryptophan
- L-Tryptophan
- L Tryptophan
- Levotryptophan
Ardeydorm- Ardeydorm
- Ardeytropin
- Ardeypharm Brand of Tryptophan
L-Tryptophan-ratiopharm- L-Tryptophan-ratiopharm
- L Tryptophan ratiopharm
- Ratiopharm Brand of Tryptophan
- ratio-Tryptophan
- ratio Tryptophan
PMS-Tryptophan- PMS-Tryptophan
- PMS Tryptophan
- Pharmascience Brand of Tryptophan
Trofan- Trofan
- Upsher-Smith Brand of Tryptophan
Optimax- Optimax
- Merck Brand of Tryptophan
Lyphan- Lyphan
- Naturruhe
- esparma Brand of Tryptophan
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Below are MeSH descriptors whose meaning is more general than "Tryptophan".
Below are MeSH descriptors whose meaning is more specific than "Tryptophan".
This graph shows the total number of publications written about "Tryptophan" by people in this website by year, and whether "Tryptophan" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1981 | 0 | 1 | 1 | | 1988 | 1 | 2 | 3 | | 1990 | 0 | 1 | 1 | | 1991 | 2 | 0 | 2 | | 1992 | 2 | 1 | 3 | | 1993 | 0 | 1 | 1 | | 1994 | 0 | 1 | 1 | | 1995 | 0 | 1 | 1 | | 1996 | 2 | 1 | 3 | | 1998 | 0 | 1 | 1 | | 1999 | 1 | 0 | 1 | | 2000 | 1 | 0 | 1 | | 2001 | 3 | 1 | 4 | | 2002 | 1 | 1 | 2 | | 2003 | 2 | 1 | 3 | | 2005 | 1 | 1 | 2 | | 2006 | 1 | 0 | 1 | | 2007 | 1 | 2 | 3 | | 2008 | 2 | 0 | 2 | | 2009 | 1 | 1 | 2 | | 2010 | 0 | 1 | 1 | | 2011 | 0 | 1 | 1 | | 2012 | 0 | 1 | 1 | | 2014 | 0 | 2 | 2 | | 2015 | 1 | 1 | 2 | | 2016 | 2 | 3 | 5 | | 2018 | 3 | 1 | 4 | | 2019 | 0 | 2 | 2 | | 2020 | 1 | 1 | 2 |
To return to the timeline, click here.
Below are the most recent publications written about "Tryptophan" by people in Profiles.
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Manzella CR, Jayawardena D, Pagani W, Li Y, Alrefai WA, Bauer J, Jung B, Weber CR, Gill RK. Serum Serotonin Differentiates Between Disease Activity States in Crohn's Patients. Inflamm Bowel Dis. 2020 09 18; 26(10):1607-1618.
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Li H, Liu T, Heinsberg LW, Lockwood MB, Wainwright DA, Jang MK, Doorenbos AZ. Systematic Review of the Kynurenine Pathway and Psychoneurological Symptoms Among Adult Cancer Survivors. Biol Res Nurs. 2020 10; 22(4):472-484.
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Labaki WW, Gu T, Murray S, Curtis JL, Yeomans L, Bowler RP, Barr RG, Comellas AP, Hansel NN, Cooper CB, Barjaktarevic I, Kanner RE, Paine R, McDonald MN, Krishnan JA, Peters SP, Woodruff PG, O'Neal WK, Diao W, He B, Martinez FJ, Standiford TJ, Stringer KA, Han MK. Serum amino acid concentrations and clinical outcomes in smokers: SPIROMICS metabolomics study. Sci Rep. 2019 08 06; 9(1):11367.
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Zhai L, Ladomersky E, Bell A, Dussold C, Cardoza K, Qian J, Lauing KL, Wainwright DA. Quantification of IDO1 enzyme activity in normal and malignant tissues. Methods Enzymol. 2019; 629:235-256.
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Lukas RV, Juhász C, Wainwright DA, James CD, Kennedy E, Stupp R, Lesniak MS. Imaging tryptophan uptake with positron emission tomography in glioblastoma patients treated with indoximod. J Neurooncol. 2019 Jan; 141(1):111-120.
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Labadie BW, Bao R, Luke JJ. Reimagining IDO Pathway Inhibition in Cancer Immunotherapy via Downstream Focus on the Tryptophan-Kynurenine-Aryl Hydrocarbon Axis. Clin Cancer Res. 2019 03 01; 25(5):1462-1471.
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Sofia MA, Ciorba MA, Meckel K, Lim CK, Guillemin GJ, Weber CR, Bissonnette M, Pekow JR. Tryptophan Metabolism through the Kynurenine Pathway is Associated with Endoscopic Inflammation in Ulcerative Colitis. Inflamm Bowel Dis. 2018 06 08; 24(7):1471-1480.
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Zhai L, Ladomersky E, Lenzen A, Nguyen B, Patel R, Lauing KL, Wu M, Wainwright DA. IDO1 in cancer: a Gemini of immune checkpoints. Cell Mol Immunol. 2018 May; 15(5):447-457.
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Sachleben JR, Adhikari AN, Gawlak G, Hoey RJ, Liu G, Joachimiak A, Montelione GT, Sosnick TR, Koide S. Aromatic claw: A new fold with high aromatic content that evades structural prediction. Protein Sci. 2017 02; 26(2):208-217.
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Poellmann MJ, Sosnick TR, Meredith SC, Lee RC. The Pentablock Amphiphilic Copolymer T1107 Prevents Aggregation of Denatured and Reduced Lysozyme. Macromol Biosci. 2017 02; 17(2).
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