"Tryptophan" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An essential amino acid that is necessary for normal growth in infants and for NITROGEN balance in adults. It is a precursor of INDOLE ALKALOIDS in plants. It is a precursor of SEROTONIN (hence its use as an antidepressant and sleep aid). It can be a precursor to NIACIN, albeit inefficiently, in mammals.
Descriptor ID |
D014364
|
MeSH Number(s) |
D12.125.072.050.850 D12.125.142.875
|
Concept/Terms |
Tryptophan- Tryptophan
- L-Tryptophan
- L Tryptophan
- Levotryptophan
|
Below are MeSH descriptors whose meaning is more general than "Tryptophan".
Below are MeSH descriptors whose meaning is more specific than "Tryptophan".
This graph shows the total number of publications written about "Tryptophan" by people in this website by year, and whether "Tryptophan" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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1994 | 0 | 1 | 1 |
1995 | 0 | 1 | 1 |
1996 | 2 | 0 | 2 |
1998 | 0 | 1 | 1 |
1999 | 1 | 0 | 1 |
2000 | 1 | 0 | 1 |
2001 | 3 | 1 | 4 |
2002 | 1 | 1 | 2 |
2003 | 2 | 1 | 3 |
2005 | 1 | 1 | 2 |
2006 | 1 | 0 | 1 |
2007 | 1 | 2 | 3 |
2008 | 2 | 0 | 2 |
2009 | 1 | 1 | 2 |
2010 | 0 | 1 | 1 |
2011 | 0 | 1 | 1 |
2012 | 0 | 1 | 1 |
2014 | 0 | 2 | 2 |
2015 | 1 | 1 | 2 |
2016 | 2 | 3 | 5 |
2017 | 1 | 0 | 1 |
2018 | 2 | 1 | 3 |
2019 | 0 | 2 | 2 |
2020 | 1 | 1 | 2 |
2021 | 2 | 2 | 4 |
2022 | 0 | 3 | 3 |
2023 | 1 | 0 | 1 |
2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Tryptophan" by people in Profiles.
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Human cytomegalovirus in breast milk is associated with milk composition and the infant gut microbiome and growth. Nat Commun. 2024 Jul 23; 15(1):6216.
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Structure, sequon recognition and mechanism of tryptophan C-mannosyltransferase. Nat Chem Biol. 2023 05; 19(5):575-584.
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Identification and Characterization of a Novel Indoleamine 2,3-Dioxygenase 1 Protein Degrader for Glioblastoma. J Med Chem. 2022 12 08; 65(23):15642-15662.
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Computational Design and Experimental Validation of ACE2-Derived Peptides as SARS-CoV-2 Receptor Binding Domain Inhibitors. J Phys Chem B. 2022 10 20; 126(41):8129-8139.
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Metabolic adaptation of ovarian tumors in patients treated with an IDO1 inhibitor constrains antitumor immune responses. Sci Transl Med. 2022 03 16; 14(636):eabg8402.
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Tracking the movement of discrete gating charges in a voltage-gated potassium channel. Elife. 2021 11 15; 10.
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Tumor Cell IDO Enhances Immune Suppression and Decreases Survival Independent of Tryptophan Metabolism in Glioblastoma. Clin Cancer Res. 2021 12 01; 27(23):6514-6528.
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Catalytically impaired TrpA subunit of tryptophan synthase from Chlamydia trachomatis is an allosteric regulator of TrpB. Protein Sci. 2021 09; 30(9):1904-1918.
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Tryptophan metabolism in brain tumors - IDO and beyond. Curr Opin Immunol. 2021 06; 70:57-66.
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Serum Serotonin Differentiates Between Disease Activity States in Crohn's Patients. Inflamm Bowel Dis. 2020 09 18; 26(10):1607-1618.