"Isoleucine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An essential branched-chain aliphatic amino acid found in many proteins. It is an isomer of LEUCINE. It is important in hemoglobin synthesis and regulation of blood sugar and energy levels.
| Descriptor ID |
D007532
|
| MeSH Number(s) |
D12.125.070.577 D12.125.142.383
|
| Concept/Terms |
Isoleucine- Isoleucine
- L-Isoleucine
- Isoleucine, L-Isomer
- Isoleucine, L Isomer
- L-Isomer Isoleucine
|
Below are MeSH descriptors whose meaning is more general than "Isoleucine".
Below are MeSH descriptors whose meaning is more specific than "Isoleucine".
This graph shows the total number of publications written about "Isoleucine" by people in this website by year, and whether "Isoleucine" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 |
| 1996 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2004 | 1 | 0 | 1 |
| 2005 | 0 | 1 | 1 |
| 2007 | 0 | 3 | 3 |
| 2008 | 1 | 0 | 1 |
| 2011 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2017 | 1 | 0 | 1 |
| 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Isoleucine" by people in Profiles.
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Serum amino acid concentrations and clinical outcomes in smokers: SPIROMICS metabolomics study. Sci Rep. 2019 08 06; 9(1):11367.
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Inversion of the Side-Chain Stereochemistry of Indvidual Thr or Ile Residues in a Protein Molecule: Impact on the Folding, Stability, and Structure of the ShK Toxin. Angew Chem Int Ed Engl. 2017 03 13; 56(12):3324-3328.
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Tuning the voltage-sensor motion with a single residue. Biophys J. 2012 Aug 08; 103(3):L23-L25.
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Thermodynamic coupling between activation and inactivation gating in potassium channels revealed by free energy molecular dynamics simulations. J Gen Physiol. 2011 Dec; 138(6):571-80.
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Targeting the SH2-kinase interface in Bcr-Abl inhibits leukemogenesis. Cell. 2011 Oct 14; 147(2):306-19.
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A molecular switch between the outer and the inner vestibules of the voltage-gated Na+ channel. J Biol Chem. 2010 Dec 10; 285(50):39458-70.
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High-resolution structure of a self-assembly-competent form of a hydrophobic peptide captured in a soluble beta-sheet scaffold. J Mol Biol. 2008 Apr 25; 378(2):459-67.
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Genetic and functional analysis of CHEK2 (CHK2) variants in multiethnic cohorts. Int J Cancer. 2007 Dec 15; 121(12):2661-7.
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An Ryr1I4895T mutation abolishes Ca2+ release channel function and delays development in homozygous offspring of a mutant mouse line. Proc Natl Acad Sci U S A. 2007 Nov 20; 104(47):18537-42.
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FLT3 D835/I836 mutations are associated with poor disease-free survival and a distinct gene-expression signature among younger adults with de novo cytogenetically normal acute myeloid leukemia lacking FLT3 internal tandem duplications. Blood. 2008 Feb 01; 111(3):1552-9.