"Protein Engineering" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Procedures by which protein structure and function are changed or created in vitro by altering existing or synthesizing new structural genes that direct the synthesis of proteins with sought-after properties. Such procedures may include the design of MOLECULAR MODELS of proteins using COMPUTER GRAPHICS or other molecular modeling techniques; site-specific mutagenesis (MUTAGENESIS, SITE-SPECIFIC) of existing genes; and DIRECTED MOLECULAR EVOLUTION techniques to create new genes.
| Descriptor ID |
D015202
|
| MeSH Number(s) |
E05.393.420.601
|
| Concept/Terms |
Protein Engineering- Protein Engineering
- Engineering, Protein
- Genetic Engineering, Protein
- Engineering, Protein Genetic
- Protein Genetic Engineering
- Proteins, Genetic Engineering
- Genetic Engineering of Proteins
|
Below are MeSH descriptors whose meaning is more general than "Protein Engineering".
Below are MeSH descriptors whose meaning is more specific than "Protein Engineering".
This graph shows the total number of publications written about "Protein Engineering" by people in this website by year, and whether "Protein Engineering" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 0 | 1 |
| 1997 | 1 | 0 | 1 |
| 1999 | 0 | 1 | 1 |
| 2000 | 1 | 0 | 1 |
| 2001 | 1 | 2 | 3 |
| 2002 | 1 | 3 | 4 |
| 2003 | 1 | 0 | 1 |
| 2004 | 1 | 4 | 5 |
| 2005 | 2 | 4 | 6 |
| 2006 | 3 | 1 | 4 |
| 2007 | 3 | 0 | 3 |
| 2008 | 3 | 1 | 4 |
| 2009 | 3 | 7 | 10 |
| 2010 | 5 | 2 | 7 |
| 2011 | 2 | 3 | 5 |
| 2012 | 3 | 2 | 5 |
| 2013 | 1 | 1 | 2 |
| 2014 | 2 | 5 | 7 |
| 2015 | 4 | 4 | 8 |
| 2016 | 1 | 4 | 5 |
| 2017 | 1 | 4 | 5 |
| 2018 | 2 | 5 | 7 |
| 2019 | 3 | 0 | 3 |
| 2020 | 2 | 1 | 3 |
| 2021 | 1 | 3 | 4 |
| 2022 | 1 | 1 | 2 |
| 2023 | 1 | 0 | 1 |
| 2025 | 2 | 0 | 2 |
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Below are the most recent publications written about "Protein Engineering" by people in Profiles.
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Engineered protein G variants for multifunctional antibody-based assemblies. Protein Sci. 2025 Feb; 34(2):e70019.
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Structural studies of the IFN?4 receptor complex using cryoEM enabled by protein engineering. Nat Commun. 2025 Jan 18; 16(1):818.
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Molecular analysis of the type III interferon complex and its applications in protein engineering. Biophys J. 2023 11 07; 122(21):4254-4263.
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Engineered human antibodies for the opsonization and killing of Staphylococcus aureus. Proc Natl Acad Sci U S A. 2022 01 25; 119(4).
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Protein Engineering: Advances in Phage Display for Basic Science and Medical Research. Biochemistry (Mosc). 2022 Jan; 87(Suppl 1):S146-S110.
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Structure of an AMPK complex in an inactive, ATP-bound state. Science. 2021 07 23; 373(6553):413-419.
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Immunoengineering approaches for cytokine therapy. Am J Physiol Cell Physiol. 2021 08 01; 321(2):C369-C383.
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Suppression of Rheumatoid Arthritis by Enhanced Lymph Node Trafficking of Engineered Interleukin-10 in Murine Models. Arthritis Rheumatol. 2021 05; 73(5):769-778.
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100th Anniversary of Macromolecular Science Viewpoint: Data-Driven Protein Design. ACS Macro Lett. 2021 03 16; 10(3):327-340.
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Engineering and characterization of a novel Self Assembling Protein for Toxoplasma peptide vaccine in HLA-A*11:01, HLA-A*02:01 and HLA-B*07:02 transgenic mice. Sci Rep. 2020 10 12; 10(1):16984.