 Protein Engineering
"Protein Engineering" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Procedures by which protein structure and function are changed or created in vitro by altering existing or synthesizing new structural genes that direct the synthesis of proteins with sought-after properties. Such procedures may include the design of MOLECULAR MODELS of proteins using COMPUTER GRAPHICS or other molecular modeling techniques; site-specific mutagenesis (MUTAGENESIS, SITE-SPECIFIC) of existing genes; and DIRECTED MOLECULAR EVOLUTION techniques to create new genes.
| Descriptor ID |
D015202
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| MeSH Number(s) |
E05.393.420.601
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| Concept/Terms |
Protein Engineering- Protein Engineering
- Engineering, Protein
- Genetic Engineering, Protein
- Engineering, Protein Genetic
- Protein Genetic Engineering
- Proteins, Genetic Engineering
- Genetic Engineering of Proteins
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Below are MeSH descriptors whose meaning is more general than "Protein Engineering".
Below are MeSH descriptors whose meaning is more specific than "Protein Engineering".
This graph shows the total number of publications written about "Protein Engineering" by people in this website by year, and whether "Protein Engineering" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1990 | 0 | 1 | 1 | | 1991 | 0 | 2 | 2 | | 1992 | 0 | 1 | 1 | | 1993 | 1 | 1 | 2 | | 1996 | 1 | 0 | 1 | | 1997 | 1 | 0 | 1 | | 1999 | 0 | 1 | 1 | | 2000 | 1 | 0 | 1 | | 2001 | 1 | 2 | 3 | | 2002 | 1 | 3 | 4 | | 2003 | 1 | 0 | 1 | | 2004 | 1 | 4 | 5 | | 2005 | 2 | 4 | 6 | | 2006 | 3 | 1 | 4 | | 2007 | 3 | 0 | 3 | | 2008 | 3 | 1 | 4 | | 2009 | 3 | 7 | 10 | | 2010 | 3 | 2 | 5 | | 2011 | 3 | 4 | 7 | | 2012 | 3 | 2 | 5 | | 2013 | 1 | 1 | 2 | | 2014 | 3 | 5 | 8 | | 2015 | 4 | 4 | 8 | | 2016 | 1 | 3 | 4 | | 2017 | 0 | 4 | 4 | | 2018 | 2 | 5 | 7 | | 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Protein Engineering" by people in Profiles.
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Guthmiller JJ, Dugan HL, Neu KE, Lan LY, Wilson PC. An Efficient Method to Generate Monoclonal Antibodies from Human B Cells. Methods Mol Biol. 2019; 1904:109-145.
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Ranganathan R. Putting Evolution to Work. Cell. 2018 11 29; 175(6):1449-1451.
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Pincus D, Pandey JP, Feder ZA, Creixell P, Resnekov O, Reynolds KA. Engineering allosteric regulation in protein kinases. Sci Signal. 2018 11 06; 11(555).
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Rauch S, He C, Dickinson BC. Targeted m6A Reader Proteins To Study Epitranscriptomic Regulation of Single RNAs. J Am Chem Soc. 2018 09 26; 140(38):11974-11981.
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Roth TL, Puig-Saus C, Yu R, Shifrut E, Carnevale J, Li PJ, Hiatt J, Saco J, Krystofinski P, Li H, Tobin V, Nguyen DN, Lee MR, Putnam AL, Ferris AL, Chen JW, Schickel JN, Pellerin L, Carmody D, Alkorta-Aranburu G, Del Gaudio D, Matsumoto H, Morell M, Mao Y, Cho M, Quadros RM, Gurumurthy CB, Smith B, Haugwitz M, Hughes SH, Weissman JS, Schumann K, Esensten JH, May AP, Ashworth A, Kupfer GM, Greeley SAW, Bacchetta R, Meffre E, Roncarolo MG, Romberg N, Herold KC, Ribas A, Leonetti MD, Marson A. Reprogramming human T cell function and specificity with non-viral genome targeting. Nature. 2018 07; 559(7714):405-409.
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Fettis MM, Hudalla GA. Engineering Reactive Oxygen Species-Resistant Galectin-1 Dimers with Enhanced Lectin Activity. Bioconjug Chem. 2018 07 18; 29(7):2489-2496.
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Dickinson BC. Controlling protein function with HCV protease. Nat Methods. 2018 07; 15(7):489-490.
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Hattori T, Koide S. Next-generation antibodies for post-translational modifications. Curr Opin Struct Biol. 2018 08; 51:141-148.
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Mukherjee S, Griffin DH, Horn JR, Rizk SS, Nocula-Lugowska M, Malmqvist M, Kim SS, Kossiakoff AA. Engineered synthetic antibodies as probes to quantify the energetic contributions of ligand binding to conformational changes in proteins. J Biol Chem. 2018 02 23; 293(8):2815-2828.
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Bailey LJ, Sheehy KM, Dominik PK, Liang WG, Rui H, Clark M, Jaskolowski M, Kim Y, Deneka D, Tang WJ, Kossiakoff AA. Locking the Elbow: Improved Antibody Fab Fragments as Chaperones for Structure Determination. J Mol Biol. 2018 02 02; 430(3):337-347.
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