Immunoglobulin Fab Fragments
"Immunoglobulin Fab Fragments" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Univalent antigen-binding fragments composed of one entire IMMUNOGLOBULIN LIGHT CHAIN and the amino terminal end of one of the IMMUNOGLOBULIN HEAVY CHAINS from the hinge region, linked to each other by disulfide bonds. Fab contains the IMMUNOGLOBULIN VARIABLE REGIONS, which are part of the antigen-binding site, and the first IMMUNOGLOBULIN CONSTANT REGIONS. This fragment can be obtained by digestion of immunoglobulins with the proteolytic enzyme PAPAIN.
| Descriptor ID |
D007140
|
| MeSH Number(s) |
D12.644.541.500.650 D12.776.124.486.485.680.650 D12.776.124.790.651.680.650 D12.776.377.715.548.680.650
|
| Concept/Terms |
Immunoglobulin Fab Fragments- Immunoglobulin Fab Fragments
- Fab Fragments, Immunoglobulin
- Immunoglobulins, Fab Fragment
- Fab Fragment Immunoglobulins
- Fragment Immunoglobulins, Fab
- Immunoglobulin Fab Fragment
- Fab Fragment, Immunoglobulin
- Fab Immunoglobulin Fragments
- Immunoglobulin Fragments, Fab
- Fab Fragments
- Immunoglobulins, Fab
|
Below are MeSH descriptors whose meaning is more general than "Immunoglobulin Fab Fragments".
Below are MeSH descriptors whose meaning is more specific than "Immunoglobulin Fab Fragments".
This graph shows the total number of publications written about "Immunoglobulin Fab Fragments" by people in this website by year, and whether "Immunoglobulin Fab Fragments" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 2 | 2 |
| 2005 | 0 | 1 | 1 |
| 2006 | 0 | 2 | 2 |
| 2007 | 1 | 2 | 3 |
| 2009 | 0 | 3 | 3 |
| 2010 | 6 | 2 | 8 |
| 2011 | 2 | 1 | 3 |
| 2012 | 1 | 2 | 3 |
| 2013 | 1 | 2 | 3 |
| 2014 | 4 | 1 | 5 |
| 2015 | 2 | 0 | 2 |
| 2016 | 3 | 0 | 3 |
| 2017 | 1 | 0 | 1 |
| 2018 | 2 | 1 | 3 |
| 2019 | 2 | 1 | 3 |
| 2020 | 1 | 1 | 2 |
| 2021 | 2 | 2 | 4 |
| 2022 | 1 | 0 | 1 |
| 2023 | 1 | 0 | 1 |
| 2024 | 1 | 0 | 1 |
| 2025 | 2 | 1 | 3 |
| 2026 | 2 | 1 | 3 |
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Below are the most recent publications written about "Immunoglobulin Fab Fragments" by people in Profiles.
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Epitope-guided Detection of a Molecular Glue-induced Ternary Complex Using Engineered Synthetic Antibody Fragments. J Mol Biol. 2026 Oct 01; 438(19):169953.
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A universal Fab targeting a conserved U1A-RNA epitope for RNA structure determination by cryo-EM. Nucleic Acids Res. 2026 May 20; 54(10).
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LDL-binding IL-10 reduces vascular inflammation in atherosclerotic mice. Nat Biomed Eng. 2026 Sep; 10(9):1843-1854.
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A universal chimeric antigen receptor (CAR)-fragment antibody binder (FAB) split system for cancer immunotherapy. Sci Adv. 2025 Jul 04; 11(27):eadv4937.
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Effect of phosphorylation barcodes on arrestin binding to a chemokine receptor. Nature. 2025 07; 643(8070):280-287.
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Phase 2 Study of the Anti-High Temperature Requirement A1 (HtrA1) Fab Galegenimab (FHTR2163) in Geographic Atrophy Secondary to Age-Related Macular Degeneration. Am J Ophthalmol. 2025 07; 275:14-26.
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Engineered protein G variants for multifunctional antibody-based assemblies. Protein Sci. 2025 02; 34(2):e70019.
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Vision Loss Reduction with Avacincaptad Pegol for Geographic Atrophy: A 12-Month Post Hoc Analysis of the GATHER1 and GATHER2 Trials. Ophthalmol Retina. 2024 11; 8(11):1052-1060.
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Engineered antigen-binding fragments for enhanced crystallization of antibody:antigen complexes. Protein Sci. 2024 01; 33(1):e4824.
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Biochemical and biophysical characterization of natural polyreactivity in antibodies. Cell Rep. 2023 10 31; 42(10):113190.