 Immunoglobulin Class Switching
"Immunoglobulin Class Switching" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Gene rearrangement of the B-lymphocyte which results in a substitution in the type of heavy-chain constant region that is expressed. This allows the effector response to change while the antigen binding specificity (variable region) remains the same. The majority of class switching occurs by a DNA recombination event but it also can take place at the level of RNA processing.
| Descriptor ID |
D017578
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| MeSH Number(s) |
G05.355.330.401.501.450 G12.425.742.500.501.450 G12.500.349.500.501.450
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| Concept/Terms |
Immunoglobulin Class Switching- Immunoglobulin Class Switching
- Class Switching, Immunoglobulin
- Class Switchings, Immunoglobulin
- Immunoglobulin Class Switchings
- Switching, Immunoglobulin Class
- Switchings, Immunoglobulin Class
- Class Switching
- Class Switchings
- Switching, Class
- Switchings, Class
- Isotype Switching
- Isotype Switchings
- Switching, Isotype
- Switchings, Isotype
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Below are MeSH descriptors whose meaning is more general than "Immunoglobulin Class Switching".
Below are MeSH descriptors whose meaning is more specific than "Immunoglobulin Class Switching".
This graph shows the total number of publications written about "Immunoglobulin Class Switching" by people in this website by year, and whether "Immunoglobulin Class Switching" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 0 | 1 | | 2000 | 0 | 2 | 2 | | 2001 | 1 | 0 | 1 | | 2004 | 1 | 1 | 2 | | 2005 | 1 | 0 | 1 | | 2006 | 3 | 1 | 4 | | 2007 | 1 | 1 | 2 | | 2008 | 0 | 1 | 1 | | 2009 | 1 | 0 | 1 | | 2010 | 1 | 0 | 1 | | 2011 | 0 | 1 | 1 | | 2012 | 1 | 0 | 1 | | 2014 | 0 | 1 | 1 | | 2015 | 1 | 0 | 1 | | 2016 | 1 | 0 | 1 | | 2017 | 2 | 0 | 2 | | 2018 | 1 | 0 | 1 | | 2021 | 2 | 1 | 3 |
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Below are the most recent publications written about "Immunoglobulin Class Switching" by people in Profiles.
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Lehrke MJ, Shapiro MJ, Rajcula MJ, Kennedy MM, McCue SA, Medina KL, Shapiro VS. The mitochondrial iron transporter ABCB7 is required for B cell development, proliferation, and class switch recombination in mice. Elife. 2021 11 11; 10.
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Reiman D, Manakkat Vijay GK, Xu H, Sonin A, Chen D, Salomonis N, Singh H, Khan AA. Pseudocell Tracer-A method for inferring dynamic trajectories using scRNAseq and its application to B cells undergoing immunoglobulin class switch recombination. PLoS Comput Biol. 2021 05; 17(5):e1008094.
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Kennedy DE, Clark MR. Compartments and Connections Within the Germinal Center. Front Immunol. 2021; 12:659151.
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Kalinina O, Louzoun Y, Wang Y, Utset T, Weigert M. Origins and specificity of auto-antibodies in Sm+ SLE patients. J Autoimmun. 2018 06; 90:94-104.
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Seo GY, Lee JM, Jang YS, Kang SG, Yoon SI, Ko HJ, Lee GS, Park SR, Nagler CR, Kim PH. Mechanism underlying the suppressor activity of retinoic acid on IL4-induced IgE synthesis and its physiological implication. Cell Immunol. 2017 Dec; 322:49-55.
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Feldman S, Wuerffel R, Achour I, Wang L, Carpenter PB, Kenter AL. 53BP1 Contributes to Igh Locus Chromatin Topology during Class Switch Recombination. J Immunol. 2017 03 15; 198(6):2434-2444.
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Perera J, Zheng Z, Li S, Gudjonson H, Kalinina O, Benichou JIC, Block KE, Louzoun Y, Yin D, Chong AS, Dinner AR, Weigert M, Huang H. Self-Antigen-Driven Thymic B Cell Class Switching Promotes T Cell Central Tolerance. Cell Rep. 2016 10 04; 17(2):387-398.
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Feldman S, Achour I, Wuerffel R, Kumar S, Gerasimova T, Sen R, Kenter AL. Constraints contributed by chromatin looping limit recombination targeting during Ig class switch recombination. J Immunol. 2015 Mar 01; 194(5):2380-9.
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Roduit C, Frei R, Depner M, Schaub B, Loss G, Genuneit J, Pfefferle P, Hyvärinen A, Karvonen AM, Riedler J, Dalphin JC, Pekkanen J, von Mutius E, Braun-Fahrländer C, Lauener R. Increased food diversity in the first year of life is inversely associated with allergic diseases. J Allergy Clin Immunol. 2014 Apr; 133(4):1056-64.
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Kenter AL, Feldman S, Wuerffel R, Achour I, Wang L, Kumar S. Three-dimensional architecture of the IgH locus facilitates class switch recombination. Ann N Y Acad Sci. 2012 Sep; 1267:86-94.
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