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John Blair

AddressChicago IL 60637
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    John Blair, MD, FACC, is a cardiologist who specializes in the care of complex coronary artery disease, mitral and aortic valve disease and congestive heart failure. Dr. Blair performs a wide range of procedures for the diagnosis and treatment of coronary artery disease, including radial artery catheterization, balloon angioplasty, coronary stent placement, rotational orbital and excimer laser atherectomy, and treatment of chronic total occlusions (CTOs).

    Dr. Blair is also a member of the structural heart team, and treats mitral and aortic valve disease. He is one of the primary operators for the transcatheter mitral valve repair (MitraClip) procedures, and has extensive experience in transcatheter aortic valve replacement (TAVR).

    He is one of few cardiologists who perform coronary physiology studies, which aid in diagnosing coronary microvascular dysfunction in a range of challenging clinical scenarios. His research interests focus on coronary microvascular dysfunction in patients with various cardiovascular conditions, including heart failure with preserved ejection fraction (HFpEF) and CTOs.

    Prior to joining the University of Chicago Medicine, Dr. Blair was a Major in the United States Air Force Medical Corps, where he served as staff cardiologist at the San Antonio Military Medical Center and Wilford Hall Medical Center in San Antonio, Texas.


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    University of Chicago Pritzker School of Medicine, ChicagoMD06/2003
    Carleton College, Northfield, MNBA06/1999Chemistry

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Kawaji K, Nazir N, Blair JA, Mor-Avi V, Besser S, Matsumoto K, Goes JP, Dabir D, Stoiber L, Kelle S, Zamani SM, Holzhauser L, Lang RM, Patel AR. Quantitative detection of changes in regional wall motion using real time strain-encoded cardiovascular magnetic resonance. Magn Reson Imaging. 2019 Sep 01. PMID: 31484044.
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    2. Venturini JM, McClelland I, Blair JEA, Narang A, Kalathiya R, Lang RM, Addetia K, Paul J, Nathan S, Shah AP. Percutaneous Transapical Left Ventricular Access to Treat Paravalvular Leak and Ventricular Septal Defect. J Invasive Cardiol. 2019 Sep; 31(9):247-252. PMID: 31199350.
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    3. Kaur K, Cisneros M, Nathan S, Blair JEA, Balkhy HH. Percutaneous Coronary Intervention following Placement of Sutureless Aortic Bioprostheses. Innovations (Phila). 2019 Apr; 14(2):177-182. PMID: 30885090.
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    4. Bharmal MI, Venturini JM, Chua RFM, Sharp WW, Beiser DG, Tabit CE, Hirai T, Rosenberg JR, Friant J, Blair JEA, Paul JD, Nathan S, Shah AP. Cost-utility of extracorporeal cardiopulmonary resuscitation in patients with cardiac arrest. Resuscitation. 2019 03; 136:126-130. PMID: 30716427.
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    5. Hirai T, Rosenberg J, Nathan S, Blair JEA. Broken arrow: Successful retrieval of a dislodged coronary orbital atherectomy microtip. Catheter Cardiovasc Interv. 2018 09 01; 92(3):511-514. PMID: 30019818.
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    6. Hirai T, Tate S, Dryer K, Jones D, Rosenberg J, Nathan S, Shah AP, Carey K, Churpek M, Edelson D, Friant J, Paul J, Blair JEA. Electronic cardiac arrest triage score best predicts mortality after intervention in patients with massive and submassive pulmonary embolism. Catheter Cardiovasc Interv. 2018 08 01; 92(2):366-371. PMID: 29745451.
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    7. Dryer K, Gajjar M, Narang N, Lee M, Paul J, Shah AP, Nathan S, Butler J, Davidson CJ, Fearon WF, Shah SJ, Blair JEA. Coronary microvascular dysfunction in patients with heart failure with preserved ejection fraction. Am J Physiol Heart Circ Physiol. 2018 05 01; 314(5):H1033-H1042. PMID: 29424571.
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    8. Shimizu T, Narang N, Chen P, Yu B, Knapp M, Janardanan J, Blair J, Liao JK. Fibroblast deletion of ROCK2 attenuates cardiac hypertrophy, fibrosis, and diastolic dysfunction. JCI Insight. 2017 Jul 06; 2(13). PMID: 28679962.
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    9. Narang N, Medvedofsky D, Dryer K, Shah SJ, Davidson CJ, Patel AR, Blair JEA. Microvascular dysfunction and cardiac fibrosis in heart failure with preserved ejection fraction: a case report. ESC Heart Fail. 2017 11; 4(4):645-648. PMID: 29154426.
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    10. Venturini JM, Retzer E, Estrada JR, Friant J, Beiser D, Edelson D, Paul J, Blair J, Nathan S, Shah AP. Mechanical chest compressions improve rate of return of spontaneous circulation and allow for initiation of percutaneous circulatory support during cardiac arrest in the cardiac catheterization laboratory. Resuscitation. 2017 06; 115:56-60. PMID: 28377296.
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    11. Mediratta A, Addetia K, Medvedofsky D, Schneider RJ, Kruse E, Shah AP, Nathan S, Paul JD, Blair JE, Ota T, Balkhy HH, Patel AR, Mor-Avi V, Lang RM. 3D echocardiographic analysis of aortic annulus for transcatheter aortic valve replacement using novel aortic valve quantification software: Comparison with computed tomography. Echocardiography. 2017 May; 34(5):690-699. PMID: 28345211.
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    12. Blair JEA, Atri P, Friedman JL, Thomas JD, Brummel K, Sweis RN, Mikati I, Malaisrie SC, Davidson CJ, Flaherty JD. Diastolic Function and Transcatheter Aortic Valve Replacement. J Am Soc Echocardiogr. 2017 Jun; 30(6):541-551. PMID: 28314622.
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    13. Patel KV, Leef JA, Blair JE, Shah AP, Nathan S, Paul JD. Catheter-Directed Fibrinolysis of Submassive Pulmonary Embolism After IVC Filter Migration to Renal Veins. J Invasive Cardiol. 2017 Jan; 29(1):E8-E9. PMID: 28045672.
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    14. Patel AR, Blair JA. Heart Failure With Preserved Ejection Fraction: Have We Finally Found the Perfect Noninvasive Biomarker? Circ Cardiovasc Imaging. 2016 12; 9(12). PMID: 27974409.
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    15. Venturini JM, Retzer EM, Estrada JR, Mediratta A, Friant J, Nathan S, Paul JD, Blair J, Lang RM, Shah AP. A Practical Scoring System to Select Optimally Sized Devices for Percutaneous Patent Foramen Ovale Closure. J Struct Heart Dis. 2016 Oct; 2(5):217-223. PMID: 29104878.
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    16. Grinstein J, Estrada J, Sayer G, Kim GH, Sarswat N, Adatya S, Nathan S, Paul JD, Blair JE, Jeevanandam V, Lang R, Uriel N, Shah AP. Left Ventricular Assist Device Deactivation via Percutaneous Closure of the Outflow Graft. J Card Fail. 2016 Aug; 22(8):653-5. PMID: 27291686.
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    17. Lee L, Blair J, Gupta S, Nathan S. Upper extremity vascular complications following transradial approach for cardiac catheterization and intervention: a focused review of diagnostic, prognostic and therapeutic considerations. Minerva Cardioangiol. 2016 Dec; 64(6):648-61. PMID: 27175978.
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    18. Narang A, Mediratta A, Estrada JR, Rosenberg J, DeCara JM, Howell MD, Lang RM, Paul JD, Nathan S, Shah AP, Blair JE. Transcatheter Therapy for a Large Mobile Right Atrial Thrombus and Massive Pulmonary Embolism. J Invasive Cardiol. 2016 May; 28(5):E49-51. PMID: 27145056.
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    19. Czobor P, Venturini JM, Parikh KS, Retzer EM, Friant J, Jeevanandam V, Russo MJ, Uriel N, Paul JD, Blair JE, Nathan S, Shah AP. Sequential Organ Failure Assessment Score at Presentation Predicts Survival in Patients Treated With Percutaneous Veno-Arterial Extracorporeal Membrane Oxygenation. J Invasive Cardiol. 2016 Apr; 28(4):133-8. PMID: 26887027.
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    20. Blair JEA, Brummel K, Friedman JL, Atri P, Sweis RN, Russell H, Ricciardi MJ, Malaisrie SC, Davidson CJ, Flaherty JD. Inhospital and Post-discharge Changes in Renal Function After Transcatheter Aortic Valve Replacement. Am J Cardiol. 2016 Feb 15; 117(4):633-639. PMID: 26721656.
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    21. Chavez JF, Doll JA, Mediratta A, Maffessanti F, Friant J, Paul JD, Blair JE, Nathan S, Jolly N, Shah AP. Factors Associated with the Use of Drug-Eluting Stents in Patients Presenting with Acute ST-Segment Elevation Myocardial Infarction. Cardiol Res Pract. 2015; 2015:528753. PMID: 26106504.
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    22. Choi AW, Blair JE, Flaherty JD. Abciximab-induced alveolar hemorrhage treated with rescue extracorporeal membranous oxygenation. Catheter Cardiovasc Interv. 2015 Apr; 85(5):828-31. PMID: 25381962.
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    23. Huded CP, Blair JE, Sweis RN, Flaherty JD. Transradial cardiac catheterization in liver transplant candidates. Am J Cardiol. 2014 May 15; 113(10):1634-8. PMID: 24698460.
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    24. Blair JE, Ricciardi MJ. Assessment of coronary blood flow in the cardiac catheterization laboratory. Curr Probl Cardiol. 2014 Jun; 39(6):159-84. PMID: 24856032.
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    25. Blair JE, Huffman M, Shah SJ. Heart failure in North America. Curr Cardiol Rev. 2013 May; 9(2):128-46. PMID: 23597296.
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    26. Vaduganathan M, Gheorghiade M, Pang PS, Konstam MA, Zannad F, Swedberg K, Grinfeld L, Burnett JC, Krasa HB, Zimmer C, Blair J, Ouyang J, Maggioni AP. Efficacy of oral tolvaptan in acute heart failure patients with hypotension and renal impairment. J Cardiovasc Med (Hagerstown). 2012 Jul; 13(7):415-22. PMID: 22673023.
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    27. Blair JE, Pang PS, Schrier RW, Metra M, Traver B, Cook T, Campia U, Ambrosy A, Burnett JC, Grinfeld L, Maggioni AP, Swedberg K, Udelson JE, Zannad F, Konstam MA, Gheorghiade M. Changes in renal function during hospitalization and soon after discharge in patients admitted for worsening heart failure in the placebo group of the EVEREST trial. Eur Heart J. 2011 Oct; 32(20):2563-72. PMID: 21785107.
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    28. O'Connor CM, Miller AB, Blair JE, Konstam MA, Wedge P, Bahit MC, Carson P, Haass M, Hauptman PJ, Metra M, Oren RM, Patten R, Piña I, Roth S, Sackner-Bernstein JD, Traver B, Cook T, Gheorghiade M. Causes of death and rehospitalization in patients hospitalized with worsening heart failure and reduced left ventricular ejection fraction: results from Efficacy of Vasopressin Antagonism in Heart Failure Outcome Study with Tolvaptan (EVEREST) program. Am Heart J. 2010 May; 159(5):841-849.e1. PMID: 20435194.
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    29. Gheorghiade M, Follath F, Ponikowski P, Barsuk JH, Blair JE, Cleland JG, Dickstein K, Drazner MH, Fonarow GC, Jaarsma T, Jondeau G, Sendon JL, Mebazaa A, Metra M, Nieminen M, Pang PS, Seferovic P, Stevenson LW, van Veldhuisen DJ, Zannad F, Anker SD, Rhodes A, McMurray JJ, Filippatos G. Assessing and grading congestion in acute heart failure: a scientific statement from the acute heart failure committee of the heart failure association of the European Society of Cardiology and endorsed by the European Society of Intensive Care Medicine. Eur J Heart Fail. 2010 May; 12(5):423-33. PMID: 20354029.
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    30. Goonewardena SN, Blair JE, Manuchehry A, Brennan JM, Keller M, Reeves R, Price A, Spencer KT, Puthumana J, Gheorghiade M. Use of hand carried ultrasound, B-type natriuretic peptide, and clinical assessment in identifying abnormal left ventricular filling pressures in patients referred for right heart catheterization. J Card Fail. 2010 Jan; 16(1):69-75. PMID: 20123321.
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    31. Gheorghiade M, Khan S, Blair JE, Harinstein ME, Krum H, Mukherjee R, Pitt B. The effects of eplerenone on length of stay and total days of heart failure hospitalization after myocardial infarction in patients with left ventricular systolic dysfunction. Am Heart J. 2009 Sep; 158(3):437-43. PMID: 19699868.
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    32. Pang PS, Konstam MA, Krasa HB, Swedberg K, Zannad F, Blair JE, Zimmer C, Teerlink JR, Maggioni AP, Burnett JC, Grinfeld L, Ouyang J, Udelson JE, Gheorghiade M. Effects of tolvaptan on dyspnoea relief from the EVEREST trials. Eur Heart J. 2009 Sep; 30(18):2233-40. PMID: 19561338.
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    33. Blair JE, Khan S, Konstam MA, Swedberg K, Zannad F, Burnett JC, Grinfeld L, Maggioni AP, Udelson JE, Zimmer CA, Ouyang J, Chen CF, Gheorghiade M. Weight changes after hospitalization for worsening heart failure and subsequent re-hospitalization and mortality in the EVEREST trial. Eur Heart J. 2009 Jul; 30(13):1666-73. PMID: 19411662.
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    34. Shah SJ, Blair JE, Filippatos GS, Macarie C, Ruzyllo W, Korewicki J, Bubenek-Turconi SI, Ceracchi M, Bianchetti M, Carminati P, Kremastinos D, Grzybowski J, Valentini G, Sabbah HN, Gheorghiade M. Effects of istaroxime on diastolic stiffness in acute heart failure syndromes: results from the Hemodynamic, Echocardiographic, and Neurohormonal Effects of Istaroxime, a Novel Intravenous Inotropic and Lusitropic Agent: a Randomized Controlled Trial in Patients Hospitalized with Heart Failure (HORIZON-HF) trial. Am Heart J. 2009 Jun; 157(6):1035-41. PMID: 19464414.
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    35. Khan H, Metra M, Blair JE, Vogel M, Harinstein ME, Filippatos GS, Sabbah HN, Porchet H, Valentini G, Gheorghiade M. Istaroxime, a first in class new chemical entity exhibiting SERCA-2 activation and Na-K-ATPase inhibition: a new promising treatment for acute heart failure syndromes? Heart Fail Rev. 2009 Dec; 14(4):277-87. PMID: 19238540.
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    36. Blair JE, Zannad F, Konstam MA, Cook T, Traver B, Burnett JC, Grinfeld L, Krasa H, Maggioni AP, Orlandi C, Swedberg K, Udelson JE, Zimmer C, Gheorghiade M. Continental differences in clinical characteristics, management, and outcomes in patients hospitalized with worsening heart failure results from the EVEREST (Efficacy of Vasopressin Antagonism in Heart Failure: Outcome Study with Tolvaptan) program. J Am Coll Cardiol. 2008 Nov 11; 52(20):1640-8. PMID: 18992654.
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    37. Blair JE, Brennan JM, Goonewardena SN, Shah D, Vasaiwala S, Spencer KT. Usefulness of hand-carried ultrasound to predict elevated left ventricular filling pressure. Am J Cardiol. 2009 Jan 15; 103(2):246-7. PMID: 19121445.
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    38. Goonewardena SN, Gemignani A, Ronan A, Vasaiwala S, Blair J, Brennan JM, Shah DP, Spencer KT. Comparison of hand-carried ultrasound assessment of the inferior vena cava and N-terminal pro-brain natriuretic peptide for predicting readmission after hospitalization for acute decompensated heart failure. JACC Cardiovasc Imaging. 2008 Sep; 1(5):595-601. PMID: 19356487.
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    39. O'Connell JB, McCarthy PM, Sopko G, Filippatos GS, Piña IL, Konstam MA, Young JB, Miller LW, Mehra MR, Roland E, Blair JE, Farrar DJ, Gheorghiade M. Mechanical circulatory support devices for acute heart failure syndromes: considerations for clinical trial design. Heart Fail Rev. 2009 Jun; 14(2):101-12. PMID: 18548344.
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    40. Blair JE, Macarie C, Ruzyllo W, Bacchieri A, Valentini G, Bianchetti M, Pang PS, Harinstein ME, Sabbah HN, Filippatos GS, Gheorghiade M. Rationale and design of the hemodynamic, echocardiographic and neurohormonal effects of istaroxime, a novel intravenous inotropic and lusitropic agent: a randomized controlled trial in patients hospitalized with heart failure (HORIZON-HF) trial. Am J Ther. 2008 May-Jun; 15(3):231-40. PMID: 18496261.
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    41. Gheorghiade M, Blair JE, Filippatos GS, Macarie C, Ruzyllo W, Korewicki J, Bubenek-Turconi SI, Ceracchi M, Bianchetti M, Carminati P, Kremastinos D, Valentini G, Sabbah HN. Hemodynamic, echocardiographic, and neurohormonal effects of istaroxime, a novel intravenous inotropic and lusitropic agent: a randomized controlled trial in patients hospitalized with heart failure. J Am Coll Cardiol. 2008 Jun 10; 51(23):2276-85. PMID: 18534276.
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    42. Brandimarte F, Blair JE, Manuchehry A, Fedele F, Gheorghiade M. Aldosterone receptor blockade in patients with left ventricular systolic dysfunction following acute myocardial infarction. Cardiol Clin. 2008 Feb; 26(1):91-105, vii. PMID: 18312909.
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    43. Brennan JM, Blair JE, Goonewardena S, Ronan A, Shah D, Vasaiwala S, Kirkpatrick JN, Spencer KT. Reappraisal of the use of inferior vena cava for estimating right atrial pressure. J Am Soc Echocardiogr. 2007 Jul; 20(7):857-61. PMID: 17617312.
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    44. Brennan JM, Blair JE, Hampole C, Goonewardena S, Vasaiwala S, Shah D, Spencer KT, Schmidt GA. Radial artery pulse pressure variation correlates with brachial artery peak velocity variation in ventilated subjects when measured by internal medicine residents using hand-carried ultrasound devices. Chest. 2007 May; 131(5):1301-7. PMID: 17494781.
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    45. Brennan JM, Blair JE, Goonewardena S, Ronan A, Shah D, Vasaiwala S, Brooks E, Levy A, Kirkpatrick JN, Spencer KT. A comparison by medicine residents of physical examination versus hand-carried ultrasound for estimation of right atrial pressure. Am J Cardiol. 2007 Jun 01; 99(11):1614-6. PMID: 17531592.
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    46. Blair JE, Manuchehry A, Chana A, Rossi J, Schrier RW, Burnett JC, Gheorghiade M. Prognostic markers in heart failure--congestion, neurohormones, and the cardiorenal syndrome. Acute Card Care. 2007; 9(4):207-13. PMID: 17891672.
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    47. Brennan JM, Ronan A, Goonewardena S, Blair JE, Hammes M, Shah D, Vasaiwala S, Kirkpatrick JN, Spencer KT. Handcarried ultrasound measurement of the inferior vena cava for assessment of intravascular volume status in the outpatient hemodialysis clinic. Clin J Am Soc Nephrol. 2006 Jul; 1(4):749-53. PMID: 17699282.
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