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Willard W. Sharp

TitleAssociate Professor
InstitutionUniversity of Chicago
DepartmentMedicine-Emergency Medicine
AddressChicago IL 60637
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    Collapse Biography 
    Collapse education and training
    Wofford College, Spartanburg, SCBS08/1989Biology and History
    University of South Carolina, Columbia, SCPhD12/1994Biomedical Science
    University of South Carolina, Columbia, SCMD05/2003Medicine
    University of Illinois at Chicago, Chicago, ILPost-Doctoral Work05/1998
    Collapse awards and honors
    2014SAEM Young Investigator Award, Society for Academic Emergency Medicine
    2013Best Resuscitation Abstract Award, Scientific Sessions, Amercian Heart Association
    2008 - 2010Resuscitation Science Young Investigator Award, American Heart Association
    2007Civilian Citation for Cardiac Arrest Assistance, Canton, Michigan Fire Department
    1985Eagle Scout, Boy Scouts of America
    2016Best Abstract Award (Translational Medicine), Department of Medicine Janet Rowley Research Day, University of Chicago
    2017Best Abstract Award (Basic Science), Department of Medicine Janet Rowley Research Day, University of Chicago

    Collapse Research 
    Collapse research activities and funding
    R01HL133675     (SHARP, WILLARD WILLIAM)Jul 1, 2016 - Apr 30, 2021
    NIH
    Pharmacological Induced Torpor/Hypothermia As A Novel Therapy for Improving Post Cardiac Arrest Resuscitation Outcomes
    Role: Principal Investigator
    R03HL110826     (SHARP, WILLARD WILLIAM)Aug 1, 2012 - Jun 30, 2014
    NIH
    Mitochondrial dynamics in human pulmonary hypertension: a new therapeutic target
    Role: Principal Investigator
    K08HL103901     (SHARP, WILLARD WILLIAM)Jun 10, 2011 - Mar 31, 2016
    NIH
    Hypothermia in Cardiac Arrest: Akt Preservation of Mitochondrial Integrity
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Maher PJ, Rothman R, Neumar R, Brown J, Sharp W, Cairns C, Kelen GD, Kaji A, Vogel JA, Richardson LD. T32 programs in emergency medicine: A report from the ACEP-SAEM Federal Research Funding Workgroup. Acad Emerg Med. 2024 Oct; 31(10):1050-1057. PMID: 39152536.
      Citations:    Fields:    Translation:Humans
    2. Pulcini CD, Barton DJ, Cassara M, Davis JJ, DeMasi SC, Durant EJ, Garg N, Greineder C, McMillian M, Paxton JH, Puskarich MA, Vogel JA, Wong AH, Sharp WW. Assessment of an organizational effort to increase emergency medicine faculty on National Institutes of Health study sections. Acad Emerg Med. 2024 Jul 26. PMID: 39056157.
      Citations:    Fields:    
    3. Ullah K, Li Y, Liu L, Zhang Q, Pan K, Humayun Z, Sitikov A, Fang Y, Wu D, Liao JK, Wu R, Ai L, Piao L, Su Q, Zhao Q, Sharp W. A Novel ARNT-Dependent HIF-2a Signaling as a Protective Mechanism for Cardiac Microvascular Barrier Integrity and Heart Function Post-Myocardial Infarction. bioRxiv. 2024 Apr 27. PMID: 36993497; PMCID: PMC10054928.
      Citations:    
    4. Sharp WW, Beiser DG. Hands free pulse checks: The future of CPR. Resuscitation. 2024 02; 195:110121. PMID: 38272387.
      Citations:    Fields:    Translation:Humans
    5. Piao L, Fang YH, Fisher M, Hamanaka RB, Ousta A, Wu R, Mutlu GM, Garcia AJ, Archer SL, Sharp WW. Dynamin-related protein 1 is a critical regulator of mitochondrial calcium homeostasis during myocardial ischemia/reperfusion injury. FASEB J. 2024 01; 38(1):e23379. PMID: 38133921.
      Citations: 2     Fields:    Translation:AnimalsCells
    6. Stanford KA, Macias-Konstantopoulos W, Linden J, Agrawal P, Cortes E, Barron RJ, Stoklosa H, Dekker AM, Paxton J, Knack S, Sharp WW, SAEM Research Committee. SAEM Response to the National Institutes of Health request for information: Future directions in violence against women research. Acad Emerg Med. 2023 11; 30(11):1161-1167. PMID: 37423251.
      Citations:    Fields:    Translation:Humans
    7. Pratt A, Tataris K, Sharp WW. Community Response Programs: The Real Question Is "Are They Scalable?" Ann Emerg Med. 2023 07; 82(1):118-119. PMID: 37349070.
      Citations:    Fields:    Translation:Humans
    8. Ullah K, Li Y, Lin Q, Pan K, Nguyen T, Aniruddhsingh S, Su Q, Sharp W, Wu R. Comparative Analysis of Whole Transcriptome Profiles in Septic Cardiomyopathy: Insights from CLP- and LPS-Induced Mouse Models. Genes (Basel). 2023 06 28; 14(7). PMID: 37510271; PMCID: PMC10379808.
      Citations: 2     Fields:    Translation:AnimalsCells
    9. Read AD, Bentley RET, Martin AY, Mewburn JD, Alizadeh E, Wu D, Lima PDA, Dunham-Snary KJ, Thébaud B, Sharp W, Archer SL. Electron Leak From the Mitochondrial Electron Transport Chain Complex I at Site IQ Is Crucial for Oxygen Sensing in Rabbit and Human Ductus Arteriosus. J Am Heart Assoc. 2023 07 04; 12(13):e029131. PMID: 37345832; PMCID: PMC10356098.
      Citations:    Fields:    Translation:HumansAnimalsCells
    10. Knack SK, Kim H, Paxton J, Garg N, Lumba-Brown A, Levy P, Puskarich M, Silbergleit R, D'Onofrio G, Adeoye O, Kang C, Diercks D, Neumar R, Sharp WW, the ACEP and SAEM Research Committees. ACEP-SAEM response to the National Institutes of Health (NIH) proposal to simplify the review framework for research project grant applications. Acad Emerg Med. 2023 09; 30(9):963-964. PMID: 36995344; PMCID: PMC10598805.
      Citations:    Fields:    Translation:Humans
    11. Woods PS, Kimmig LM, Sun KA, Meliton AY, Shamaa OR, Tian Y, Sharp WW, Hamanaka RB, Cetin-Atalay R, Mutlu GM. HIF-1a induces glycolytic reprograming in tissue-resident alveolar macrophages to promote cell survival during acute lung injury. Elife. 2022 07 13; 11. PMID: 35822617; PMCID: PMC9323005.
      Citations: 12     Fields:    Translation:AnimalsCells
    12. Moore AB, Puskarich M, Vogel JA, Brown J, Sharp WW. Emergency medicine faculty serving on standing NIH and AHRQ study sections from 2019 to 2020. Acad Emerg Med. 2022 01; 29(1):118-122. PMID: 34250678.
      Citations:    Fields:    Translation:Humans
    13. Jarou ZJ, Beiser DG, Sharp WW, Chacko R, Goode D, Rubin DS, Kurian D, Dalton A, Estime SR, O'Connor M, Patel BK, Kress JP, Spiegel TF. Emergency Department-initiated High-flow Nasal Cannula for COVID-19 Respiratory Distress. West J Emerg Med. 2021 Jul 20; 22(4):979-987. PMID: 35354003; PMCID: PMC8328178.
      Citations: 3     Fields:    Translation:HumansPHPublic Health
    14. Ousta A, Piao L, Fang YH, Vera A, Nallamothu T, Garcia AJ, Sharp WW. Microglial Activation and Neurological Outcomes in a Murine Model of Cardiac Arrest. Neurocrit Care. 2022 02; 36(1):61-70. PMID: 34268646; PMCID: PMC8813848.
      Citations: 5     Fields:    Translation:AnimalsCells
    15. Zhang HJ, Mitchell S, Fang YH, Tsai HM, Piao L, Ousta A, Leoni L, Chen CT, Sharp WW. Assessment of Brain Glucose Metabolism Following Cardiac Arrest by [18F]FDG Positron Emission Tomography. Neurocrit Care. 2021 02; 34(1):64-72. PMID: 32358767; PMCID: PMC7606281.
      Citations: 4     Fields:    Translation:HumansAnimals
    16. Zaidi HQ, Li S, Beiser DG, Tataris KL, Sharp WW. The utility of computed tomography to evaluate thoracic complications after cardiopulmonary resuscitation. Resusc Plus. 2020 Sep; 3:100017. PMID: 34223300; PMCID: PMC8244247.
      Citations: 3     
    17. Archer SL, Sharp WW, Weir EK. Differentiating COVID-19 Pneumonia From Acute Respiratory Distress Syndrome and High Altitude Pulmonary Edema: Therapeutic Implications. Circulation. 2020 07 14; 142(2):101-104. PMID: 32369390; PMCID: PMC7363563.
      Citations: 94     Fields:    Translation:HumansCellsPHPublic Health
    18. Piao L, Fang YH, Hamanaka RB, Dezfulian C, Archer SL, Sharp WW, Mutlu GM. Suppression of Superoxide-Hydrogen Peroxide Production at Site IQ of Mitochondrial Complex I Attenuates Myocardial Stunning and Improves Postcardiac Arrest Outcomes. Crit Care Med. 2020 02; 48(2):e133-e140. PMID: 31939812; PMCID: PMC6964871.
      Citations: 13     Fields:    Translation:AnimalsCells
    19. Piao L, Fang YH, Hamanaka RB, Mutlu GM, Dezfulian C, Archer SL, Sharp WW. Suppression of Superoxide-Hydrogen Peroxide Production at Site IQ of Mitochondrial Complex I Attenuates Myocardial Stunning and Improves Postcardiac Arrest Outcomes. Crit Care Med. 2019 Nov 13. PMID: 31725436.
      Citations:    
    20. Bharmal MI, Venturini JM, Chua RFM, Sharp WW, Beiser DG, Tabit CE, Hirai T, Rosenberg JR, Friant J, Blair JEA, Paul JD, Nathan S, Shah AP. Cost-utility of extracorporeal cardiopulmonary resuscitation in patients with cardiac arrest. Resuscitation. 2019 03; 136:126-130. PMID: 30716427.
      Citations: 23     Fields:    Translation:Humans
    21. Piao L, Fang YH, Kubler MM, Donnino MW, Sharp WW. Enhanced pyruvate dehydrogenase activity improves cardiac outcomes in a murine model of cardiac arrest. PLoS One. 2017; 12(9):e0185046. PMID: 28934276; PMCID: PMC5608301.
      Citations: 13     Fields:    Translation:Animals
    22. Pillai VB, Kanwal A, Fang YH, Sharp WW, Samant S, Arbiser J, Gupta MP. Honokiol, an activator of Sirtuin-3 (SIRT3) preserves mitochondria and protects the heart from doxorubicin-induced cardiomyopathy in mice. Oncotarget. 2017 May 23; 8(21):34082-34098. PMID: 28423723; PMCID: PMC5470953.
      Citations: 74     Fields:    Translation:AnimalsCells
    23. Tian L, Neuber-Hess M, Mewburn J, Dasgupta A, Dunham-Snary K, Wu D, Chen KH, Hong Z, Sharp WW, Kutty S, Archer SL. Ischemia-induced Drp1 and Fis1-mediated mitochondrial fission and right ventricular dysfunction in pulmonary hypertension. J Mol Med (Berl). 2017 04; 95(4):381-393. PMID: 28265681; PMCID: PMC5390778.
      Citations: 59     Fields:    Translation:AnimalsCells
    24. Pillai VB, Bindu S, Sharp W, Fang YH, Kim G, Gupta M, Samant S, Gupta MP. Sirt3 protects mitochondrial DNA damage and blocks the development of doxorubicin-induced cardiomyopathy in mice. Am J Physiol Heart Circ Physiol. 2016 Apr 15; 310(8):H962-72. PMID: 26873966; PMCID: PMC4867337.
      Citations: 65     Fields:    Translation:AnimalsCells
    25. Sharp WW. EM:RAP Commentaries in the Annals of Emergency Medicine: Peer Review and Financial Disclosure Needed. Ann Emerg Med. 2015 Jul; 66(1):90-1. PMID: 26097029.
      Citations:    Fields:    Translation:Humans
    26. Sharp WW, Davis C, McQueen A. Images in emergency medicine. Neonate with pustular rash. Neonatal methicillin-resistant staphylococcal (MRSA) pustulosis. Ann Emerg Med. 2015 Apr; 65(4):464, 469. PMID: 25805031.
      Citations:    Fields:    Translation:HumansCells
    27. Sharp WW. Change of shift. It's the Ebola. Ann Emerg Med. 2015 Apr; 65(4):457. PMID: 25805029.
      Citations:    Fields:    Translation:Humans
    28. Sharp WW. The crisis in the emergency medicine physician scientist workforce. Acad Emerg Med. 2015 Apr; 22(4):492. PMID: 25773995.
      Citations:    Fields:    Translation:Humans
    29. Sharp WW, Archer SL. Mitochondrial dynamics in cardiovascular disease: fission and fusion foretell form and function. J Mol Med (Berl). 2015 Mar; 93(3):225-8. PMID: 25669447; PMCID: PMC4338002.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    30. Sharp WW. Dynamin-related protein 1 as a therapeutic target in cardiac arrest. J Mol Med (Berl). 2015 Mar; 93(3):243-52. PMID: 25659608; PMCID: PMC4334717.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    31. Sharp WW, Beiser DG, Fang YH, Han M, Piao L, Varughese J, Archer SL. Inhibition of the mitochondrial fission protein dynamin-related protein 1 improves survival in a murine cardiac arrest model. Crit Care Med. 2015 Feb; 43(2):e38-47. PMID: 25599491; PMCID: PMC4342059.
      Citations: 44     Fields:    Translation:Animals
    32. Deal NS, Sharp WW, Orbelyan GA, Borak MH, Friant J, Shah AP, Beiser DG. The emergency cardiac arrest response team (eCART): a novel strategy for improving therapeutic hypothermia utilization following out-of-hospital cardiac arrest. Resuscitation. 2014 Dec; 85(12):1775-8. PMID: 25449348.
      Citations: 1     Fields:    Translation:Humans
    33. Sharp WW, Chan W. Images in emergency medicine. Infant with projectile vomiting. Peristaltic abdominal waves associated with infantile hypertrophic pyloric stenosis. Ann Emerg Med. 2014 Mar; 63(3):289,308. PMID: 24528943.
      Citations:    Fields:    Translation:Humans
    34. Sharp WW, Fang YH, Han M, Zhang HJ, Hong Z, Banathy A, Morrow E, Ryan JJ, Archer SL. Dynamin-related protein 1 (Drp1)-mediated diastolic dysfunction in myocardial ischemia-reperfusion injury: therapeutic benefits of Drp1 inhibition to reduce mitochondrial fission. FASEB J. 2014 Jan; 28(1):316-26. PMID: 24076965; PMCID: PMC3868827.
      Citations: 181     Fields:    Translation:AnimalsCells
    35. Ryan JJ, Marsboom G, Fang YH, Toth PT, Morrow E, Luo N, Piao L, Hong Z, Ericson K, Zhang HJ, Han M, Haney CR, Chen CT, Sharp WW, Archer SL. PGC1a-mediated mitofusin-2 deficiency in female rats and humans with pulmonary arterial hypertension. Am J Respir Crit Care Med. 2013 Apr 15; 187(8):865-78. PMID: 23449689; PMCID: PMC3707374.
      Citations: 102     Fields:    Translation:HumansAnimalsCells
    36. Hong Z, Kutty S, Toth PT, Marsboom G, Hammel JM, Chamberlain C, Ryan JJ, Zhang HJ, Sharp WW, Morrow E, Trivedi K, Weir EK, Archer SL. Role of dynamin-related protein 1 (Drp1)-mediated mitochondrial fission in oxygen sensing and constriction of the ductus arteriosus. Circ Res. 2013 Mar 01; 112(5):802-15. PMID: 23334860; PMCID: PMC3957065.
      Citations: 47     Fields:    Translation:HumansAnimalsCells
    37. Chang WT, Li J, Haung HH, Liu H, Han M, Ramachandran S, Li CQ, Sharp WW, Hamann KJ, Yuan CS, Hoek TL, Shao ZH. Baicalein protects against doxorubicin-induced cardiotoxicity by attenuation of mitochondrial oxidant injury and JNK activation. J Cell Biochem. 2011 Oct; 112(10):2873-81. PMID: 21618589; PMCID: PMC3178681.
      Citations: 26     Fields:    Translation:AnimalsCells
    38. Shao ZH, Sharp WW, Wojcik KR, Li CQ, Han M, Chang WT, Ramachandran S, Li J, Hamann KJ, Vanden Hoek TL. Therapeutic hypothermia cardioprotection via Akt- and nitric oxide-mediated attenuation of mitochondrial oxidants. Am J Physiol Heart Circ Physiol. 2010 Jun; 298(6):H2164-73. PMID: 20382860; PMCID: PMC2886635.
      Citations: 44     Fields:    Translation:AnimalsCells
    39. Shao ZH, Wojcik KR, Dossumbekova A, Hsu C, Mehendale SR, Li CQ, Qin Y, Sharp WW, Chang WT, Hamann KJ, Yuan CS, Hoek TL. Grape seed proanthocyanidins protect cardiomyocytes from ischemia and reperfusion injury via Akt-NOS signaling. J Cell Biochem. 2009 Jul 01; 107(4):697-705. PMID: 19388003.
      Citations: 12     Fields:    Translation:AnimalsCells
    40. Perhonen M, Sharp WW, Russell B. Microtubules are needed for dispersal of alpha-myosin heavy chain mRNA in rat neonatal cardiac myocytes. J Mol Cell Cardiol. 1998 Sep; 30(9):1713-22. PMID: 9769227.
      Citations: 8     Fields:    Translation:AnimalsCells
    41. Goldspink P, Sharp W, Russell B. Localization of cardiac (alpha)-myosin heavy chain mRNA is regulated by its 3' untranslated region via mechanical activity and translational block. J Cell Sci. 1997 Dec; 110 ( Pt 23):2969-78. PMID: 9359883.
      Citations: 5     Fields:    Translation:AnimalsCells
    42. Sharp WW, Simpson DG, Borg TK, Samarel AM, Terracio L. Mechanical forces regulate focal adhesion and costamere assembly in cardiac myocytes. Am J Physiol. 1997 Aug; 273(2 Pt 2):H546-56. PMID: 9277468.
      Citations: 43     Fields:    Translation:AnimalsCells
    43. Simpson DG, Sharp WW, Borg TK, Price RL, Terracio L, Samarel AM. Mechanical regulation of cardiac myocyte protein turnover and myofibrillar structure. Am J Physiol. 1996 Apr; 270(4 Pt 1):C1075-87. PMID: 8928735.
      Citations: 20     Fields:    Translation:AnimalsCells
    44. Simpson DG, Sharp WW, Borg TK, Price RL, Samarel AM, Terracio L. Mechanical regulation of cardiac myofibrillar structure. Ann N Y Acad Sci. 1995 Mar 27; 752:131-40. PMID: 7755252.
      Citations: 5     Fields:    Translation:AnimalsCells
    45. Sharp WW, Terracio L, Borg TK, Samarel AM. Contractile activity modulates actin synthesis and turnover in cultured neonatal rat heart cells. Circ Res. 1993 Jul; 73(1):172-83. PMID: 8508528.
      Citations: 13     Fields:    Translation:AnimalsCells
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