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Sebastian Fica

TitlePost Doctoral Scholar
InstitutionUniversity of Chicago
DepartmentBiochem/Mol Bio
AddressChicago IL 60637
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Aupic J, BoriĊĦek J, Fica SM, Galej WP, Magistrato A. Monovalent metal ion binding promotes the first transesterification reaction in the spliceosome. Nat Commun. 2023 Dec 20; 14(1):8482. PMID: 38123540; PMCID: PMC10733407.
      Citations:    Fields:    Translation:Cells
    2. Parker MT, Fica SM, Barton GJ, Simpson GG. Inter-species association mapping links splice site evolution to METTL16 and SNRNP27K. Elife. 2023 10 03; 12. PMID: 37787376; PMCID: PMC10581693.
      Citations: 1     Fields:    Translation:HumansCells
    3. Parker MT, Knop K, Joy N, Breidenbach F, Barton GJ, Fica SM, Soanes BK, Kusakina J, Larrieu A, Sherwood AV, Davies BH, Simpson GG. m6A modification of U6 snRNA modulates usage of two major classes of pre-mRNA 5' splice site. Elife. 2022 Nov 21; 11. PMID: 36409063.
      Citations: 8     Fields:    
    4. Wilkinson ME, Fica SM, Galej WP, Nagai K. Structural basis for conformational equilibrium of the catalytic spliceosome. Mol Cell. 2021 04 01; 81(7):1439-1452.e9. PMID: 33705709; PMCID: PMC8022279.
      Citations: 20     Fields:    Translation:AnimalsCells
    5. Strittmatter LM, Capitanchik C, Newman AJ, Hallegger M, Norman CM, Fica SM, Oubridge C, Luscombe NM, Ule J, Nagai K. psiCLIP reveals dynamic RNA binding by DEAH-box helicases before and after exon ligation. Nat Commun. 2021 03 05; 12(1):1488. PMID: 33674615; PMCID: PMC7935899.
      Citations: 7     Fields:    Translation:Cells
    6. Fica SM. Cryo-EM snapshots of the human spliceosome reveal structural adaptions for splicing regulation. Curr Opin Struct Biol. 2020 12; 65:139-148. PMID: 32717639.
      Citations: 11     Fields:    Translation:HumansCells
    7. Fica SM, Oubridge C, Wilkinson ME, Newman AJ, Nagai K. A human postcatalytic spliceosome structure reveals essential roles of metazoan factors for exon ligation. Science. 2019 02 15; 363(6428):710-714. PMID: 30705154; PMCID: PMC6386133.
      Citations: 52     Fields:    Translation:HumansCells
    8. Wilkinson ME, Fica SM, Galej WP, Norman CM, Newman AJ, Nagai K. Postcatalytic spliceosome structure reveals mechanism of 3'-splice site selection. Science. 2017 12 08; 358(6368):1283-1288. PMID: 29146871; PMCID: PMC5808836.
      Citations: 57     Fields:    Translation:AnimalsCells
    9. Fica SM, Nagai K. Cryo-electron microscopy snapshots of the spliceosome: structural insights into a dynamic ribonucleoprotein machine. Nat Struct Mol Biol. 2017 Oct 05; 24(10):791-799. PMID: 28981077; PMCID: PMC6386135.
      Citations: 92     Fields:    Translation:AnimalsCells
    10. Fica SM, Oubridge C, Galej WP, Wilkinson ME, Bai XC, Newman AJ, Nagai K. Structure of a spliceosome remodelled for exon ligation. Nature. 2017 02 16; 542(7641):377-380. PMID: 28076345; PMCID: PMC5321579.
      Citations: 86     Fields:    Translation:AnimalsCells
    11. Galej WP, Wilkinson ME, Fica SM, Oubridge C, Newman AJ, Nagai K. Cryo-EM structure of the spliceosome immediately after branching. Nature. 2016 09 08; 537(7619):197-201. PMID: 27459055; PMCID: PMC5156311.
      Citations: 127     Fields:    Translation:AnimalsCells
    12. Nguyen TH, Galej WP, Fica SM, Lin PC, Newman AJ, Nagai K. CryoEM structures of two spliceosomal complexes: starter and dessert at the spliceosome feast. Curr Opin Struct Biol. 2016 Feb; 36:48-57. PMID: 26803803; PMCID: PMC4830896.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    13. Fica SM, Mefford MA, Piccirilli JA, Staley JP. Evidence for a group II intron-like catalytic triplex in the spliceosome. Nat Struct Mol Biol. 2014 May; 21(5):464-471. PMID: 24747940; PMCID: PMC4257784.
      Citations: 56     Fields:    Translation:AnimalsCells
    14. Fica SM, Tuttle N, Novak T, Li NS, Lu J, Koodathingal P, Dai Q, Staley JP, Piccirilli JA. RNA catalyses nuclear pre-mRNA splicing. Nature. 2013 Nov 14; 503(7475):229-34. PMID: 24196718; PMCID: PMC4666680.
      Citations: 162     Fields:    Translation:AnimalsCells
    15. Schellenberg MJ, Wu T, Ritchie DB, Fica S, Staley JP, Atta KA, LaPointe P, MacMillan AM. A conformational switch in PRP8 mediates metal ion coordination that promotes pre-mRNA exon ligation. Nat Struct Mol Biol. 2013 Jun; 20(6):728-34. PMID: 23686287; PMCID: PMC3703396.
      Citations: 24     Fields:    Translation:AnimalsCells
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