 Aspartic Acid Endopeptidases
"Aspartic Acid Endopeptidases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A sub-subclass of endopeptidases that depend on an ASPARTIC ACID residue for their activity.
| Descriptor ID |
D016282
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| MeSH Number(s) |
D08.811.277.656.074.500 D08.811.277.656.300.048
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| Concept/Terms |
Aspartic Acid Endopeptidases- Aspartic Acid Endopeptidases
- Acid Endopeptidases, Aspartic
- Endopeptidases, Aspartic Acid
- Aspartic Endopeptidases
- Aspartyl Endopeptidases
- Endopeptidases, Aspartyl
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Below are MeSH descriptors whose meaning is more general than "Aspartic Acid Endopeptidases".
Below are MeSH descriptors whose meaning is more specific than "Aspartic Acid Endopeptidases".
This graph shows the total number of publications written about "Aspartic Acid Endopeptidases" by people in this website by year, and whether "Aspartic Acid Endopeptidases" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1982 | 0 | 2 | 2 | | 1994 | 1 | 1 | 2 | | 1995 | 1 | 1 | 2 | | 1996 | 2 | 1 | 3 | | 2000 | 0 | 2 | 2 | | 2001 | 1 | 2 | 3 | | 2002 | 2 | 5 | 7 | | 2003 | 1 | 3 | 4 | | 2004 | 1 | 4 | 5 | | 2005 | 1 | 4 | 5 | | 2006 | 0 | 2 | 2 | | 2007 | 0 | 1 | 1 | | 2008 | 1 | 1 | 2 | | 2010 | 0 | 1 | 1 | | 2011 | 2 | 0 | 2 | | 2012 | 1 | 0 | 1 | | 2013 | 4 | 0 | 4 | | 2014 | 1 | 0 | 1 | | 2017 | 1 | 0 | 1 | | 2018 | 1 | 0 | 1 | | 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Aspartic Acid Endopeptidases" by people in Profiles.
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Roos K, Wu C, Damm W, Reboul M, Stevenson JM, Lu C, Dahlgren MK, Mondal S, Chen W, Wang L, Abel R, Friesner RA, Harder ED. OPLS3e: Extending Force Field Coverage for Drug-Like Small Molecules. J Chem Theory Comput. 2019 Mar 12; 15(3):1863-1874.
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Andrew RJ, De Rossi P, Nguyen P, Kowalski HR, Recupero AJ, Guerbette T, Krause SV, Rice RC, Laury-Kleintop L, Wagner SL, Thinakaran G. Reduction of the expression of the late-onset Alzheimer's disease (AD) risk-factor BIN1 does not affect amyloid pathology in an AD mouse model. J Biol Chem. 2019 03 22; 294(12):4477-4487.
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Chung J, Phukan G, Vergote D, Mohamed A, Maulik M, Stahn M, Andrew RJ, Thinakaran G, Posse de Chaves E, Kar S. Endosomal-Lysosomal Cholesterol Sequestration by U18666A Differentially Regulates Amyloid Precursor Protein (APP) Metabolism in Normal and APP-Overexpressing Cells. Mol Cell Biol. 2018 06 01; 38(11).
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Sun R, He T, Pan Y, Katusic ZS. Effects of senescence and angiotensin II on expression and processing of amyloid precursor protein in human cerebral microvascular endothelial cells. Aging (Albany NY). 2018 01 15; 10(1):100-114.
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Andrew RJ, Fernandez CG, Stanley M, Jiang H, Nguyen P, Rice RC, Buggia-Prévot V, De Rossi P, Vetrivel KS, Lamb R, Argemi A, Allaert ES, Rathbun EM, Krause SV, Wagner SL, Parent AT, Holtzman DM, Thinakaran G. Lack of BACE1 S-palmitoylation reduces amyloid burden and mitigates memory deficits in transgenic mouse models of Alzheimer's disease. Proc Natl Acad Sci U S A. 2017 11 07; 114(45):E9665-E9674.
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Sadleir KR, Kandalepas PC, Buggia-Prévot V, Nicholson DA, Thinakaran G, Vassar R. Presynaptic dystrophic neurites surrounding amyloid plaques are sites of microtubule disruption, BACE1 elevation, and increased Aß generation in Alzheimer's disease. Acta Neuropathol. 2016 08; 132(2):235-256.
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Buggia-Prévot V, Thinakaran G. Significance of transcytosis in Alzheimer's disease: BACE1 takes the scenic route to axons. Bioessays. 2015 Aug; 37(8):888-98.
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Fadare O, Desouki MM, Gwin K, Hanley KZ, Jarboe EA, Liang SX, Quick CM, Zheng W, Parkash V, Hecht JL. Frequent expression of napsin A in clear cell carcinoma of the endometrium: potential diagnostic utility. Am J Surg Pathol. 2014 Feb; 38(2):189-96.
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Buggia-Prévot V, Fernandez CG, Riordan S, Vetrivel KS, Roseman J, Waters J, Bindokas VP, Vassar R, Thinakaran G. Axonal BACE1 dynamics and targeting in hippocampal neurons: a role for Rab11 GTPase. Mol Neurodegener. 2014 Jan 04; 9:1.
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Udayar V, Buggia-Prévot V, Guerreiro RL, Siegel G, Rambabu N, Soohoo AL, Ponnusamy M, Siegenthaler B, Bali J. A paired RNAi and RabGAP overexpression screen identifies Rab11 as a regulator of ß-amyloid production. Cell Rep. 2013 Dec 26; 5(6):1536-51.
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