 Leukotrienes
"Leukotrienes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of biologically active compounds derived from arachidonic acid by oxidative metabolism through the 5-lipoxygenase pathway. They participate in host defense reactions and pathophysiological conditions such as immediate hypersensitivity and inflammation. They have potent actions on many essential organs and systems, including the cardiovascular, pulmonary, and central nervous system as well as the gastrointestinal tract and the immune system.
| Descriptor ID |
D015289
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| MeSH Number(s) |
D10.251.355.255.100.450 D23.469.050.175.450
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Leukotrienes".
Below are MeSH descriptors whose meaning is more specific than "Leukotrienes".
This graph shows the total number of publications written about "Leukotrienes" by people in this website by year, and whether "Leukotrienes" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1990 | 0 | 1 | 1 | | 1991 | 2 | 0 | 2 | | 1999 | 0 | 1 | 1 | | 2000 | 3 | 0 | 3 | | 2001 | 2 | 0 | 2 | | 2002 | 1 | 0 | 1 | | 2003 | 1 | 0 | 1 | | 2007 | 0 | 2 | 2 | | 2015 | 1 | 0 | 1 |
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Below are the most recent publications written about "Leukotrienes" by people in Profiles.
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Tang F, Sally B, Lesko K, Discepolo V, Abadie V, Ciszewski C, Semrad C, Guandalini S, Kupfer SS, Jabri B. Cysteinyl leukotrienes mediate lymphokine killer activity induced by NKG2D and IL-15 in cytotoxic T cells during celiac disease. J Exp Med. 2015 Sep 21; 212(10):1487-95.
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Kheirandish-Gozal L, Kim J, Goldbart AD, Gozal D. Novel pharmacological approaches for treatment of obstructive sleep apnea in children. Expert Opin Investig Drugs. 2013 Jan; 22(1):71-85.
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Isogai S, Athiviraham A, Fraser RS, Taha R, Hamid Q, Martin JG. Interferon-gamma-dependent inhibition of late allergic airway responses and eosinophilia by CD8+ gammadelta T cells. Immunology. 2007 Oct; 122(2):230-8.
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Meliton AY, Munoz NM, Leff AR. Blockade of avidity and focal clustering of beta 2-integrin by cysteinyl leukotriene antagonism attenuates eosinophil adhesion. J Allergy Clin Immunol. 2007 Dec; 120(6):1316-23.
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Haberal I, Corey JP. The role of leukotrienes in nasal allergy. Otolaryngol Head Neck Surg. 2003 Sep; 129(3):274-9.
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Muñoz NM, Kim YJ, Meliton AY, Kim KP, Han SK, Boetticher E, O'Leary E, Myou S, Zhu X, Bonventre JV, Leff AR, Cho W. Human group V phospholipase A2 induces group IVA phospholipase A2-independent cysteinyl leukotriene synthesis in human eosinophils. J Biol Chem. 2003 Oct 03; 278(40):38813-20.
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Kim YJ, Kim KP, Han SK, Munoz NM, Zhu X, Sano H, Leff AR, Cho W. Group V phospholipase A2 induces leukotriene biosynthesis in human neutrophils through the activation of group IVA phospholipase A2. J Biol Chem. 2002 Sep 27; 277(39):36479-88.
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Leff AR. Discovery of leukotrienes and development of antileukotriene agents. Ann Allergy Asthma Immunol. 2001 Jun; 86(6 Suppl 1):4-8.
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Leff AR. Regulation of leukotrienes in the management of asthma: biology and clinical therapy. Annu Rev Med. 2001; 52:1-14.
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Kim KP, Rafter JD, Bittova L, Han SK, Snitko Y, Munoz NM, Leff AR, Cho W. Mechanism of human group V phospholipase A2 (PLA2)-induced leukotriene biosynthesis in human neutrophils. A potential role of heparan sulfate binding in PLA2 internalization and degradation. J Biol Chem. 2001 Apr 06; 276(14):11126-34.
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