"Isoprostanes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A series of prostaglandin-like compounds that are produced by the attack of free-radical species on unsaturated fatty acids, especially ARACHIDONIC ACID, of cellular MEMBRANES. Once cleaved from the lipid membrane by the action of phospholipases they can circulate into various bodily fluids and eventually be excreted. Although these compounds resemble enzymatically synthesized prostaglandins their stereoisometric arrangement is usually different than the "naturally occurring" compounds.
| Descriptor ID |
D028421
|
| MeSH Number(s) |
D10.251.355.255.100.375 D10.251.355.310.166.775 D10.251.355.411
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Isoprostanes".
Below are MeSH descriptors whose meaning is more specific than "Isoprostanes".
This graph shows the total number of publications written about "Isoprostanes" by people in this website by year, and whether "Isoprostanes" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2010 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
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Below are the most recent publications written about "Isoprostanes" by people in Profiles.
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PKCe mediates resistin-induced NADPH oxidase activation and inflammation leading to smooth muscle cell dysfunction and intimal hyperplasia. Atherosclerosis. 2016 10; 253:29-37.
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Effects of combining simvastatin with rosiglitazone on inflammation, oxidant stress and ambulatory blood pressure in patients with the metabolic syndrome: the SIROCO study. Diabetes Obes Metab. 2012 Feb; 14(2):181-6.
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Differential carbonylation of proteins as a function of in vivo oxidative stress. J Proteome Res. 2011 Sep 02; 10(9):3959-72.
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Neurochemical alterations in spinocerebellar ataxia type 1 and their correlations with clinical status. Mov Disord. 2010 Jul 15; 25(9):1253-61.
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Epoxycyclopentenone-containing oxidized phospholipids restore endothelial barrier function via Cdc42 and Rac. Circ Res. 2004 Oct 29; 95(9):892-901.