"DNA, Antisense" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
DNA that is complementary to the sense strand. (The sense strand has the same sequence as the mRNA transcript. The antisense strand is the template for mRNA synthesis.) Synthetic antisense DNAs are used to hybridize to complementary sequences in target RNAs or DNAs to effect the functioning of specific genes for investigative or therapeutic purposes.
| Descriptor ID |
D016373
|
| MeSH Number(s) |
D13.150.200 D13.444.308.150 D13.444.600.150.200 D27.720.470.530.600.150.200
|
| Concept/Terms |
DNA, Antisense- DNA, Antisense
- Anti-Sense DNA
- Anti Sense DNA
- DNA, Anti-Sense
- Antisense DNA
|
Below are MeSH descriptors whose meaning is more general than "DNA, Antisense".
Below are MeSH descriptors whose meaning is more specific than "DNA, Antisense".
This graph shows the total number of publications written about "DNA, Antisense" by people in this website by year, and whether "DNA, Antisense" was a major or minor topic of these publications.
To see the data from this visualization as text,
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 2 | 2 |
| 2000 | 0 | 1 | 1 |
| 2001 | 1 | 2 | 3 |
| 2002 | 1 | 0 | 1 |
| 2003 | 1 | 2 | 3 |
| 2004 | 0 | 1 | 1 |
| 2007 | 1 | 0 | 1 |
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Below are the most recent publications written about "DNA, Antisense" by people in Profiles.
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Adenovirus-mediated expression of cyclooxygenase-2 antisense reverse abnormal genetic profile of human adhesion fibroblasts. Fertil Steril. 2008 May; 89(5 Suppl):1455-60.
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In vivo and in vitro degradation of heparan sulfate (HS) proteoglycans by HPR1 in pancreatic adenocarcinomas. Loss of cell surface HS suppresses fibroblast growth factor 2-mediated cell signaling and proliferation. J Biol Chem. 2007 Jan 26; 282(4):2363-73.
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Human antisense genes have unusually short introns: evidence for selection for rapid transcription. Trends Genet. 2005 Apr; 21(4):203-7.
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Increased immunogenicity of colon cancer cells by selective depletion of cytochrome C. Cancer Res. 2004 Apr 15; 64(8):2705-11.
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A pea antisense gene for the chloroplast stromal processing peptidase yields seedling lethals in Arabidopsis: survivors show defective GFP import in vivo. Plant J. 2003 Jun; 34(6):802-12.
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Interleukin-11-induced heat shock protein 25 confers intestinal epithelial-specific cytoprotection from oxidant stress. Gastroenterology. 2003 May; 124(5):1358-68.
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Induction of tenascin-C by tumor-specific EWS-ETS fusion genes. Genes Chromosomes Cancer. 2003 Mar; 36(3):224-32.
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Phase I clinical and pharmacokinetic study of protein kinase C-alpha antisense oligonucleotide ISIS 3521 administered in combination with 5-fluorouracil and leucovorin in patients with advanced cancer. Clin Cancer Res. 2002 Apr; 8(4):1042-8.
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Short-chain fatty acids induce intestinal epithelial heat shock protein 25 expression in rats and IEC 18 cells. Gastroenterology. 2001 Sep; 121(3):631-9.
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Making sense (and antisense) of the X inactivation center. Proc Natl Acad Sci U S A. 2001 Aug 28; 98(18):10025-7.