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William Parker

TitleAssistant Professor
InstitutionUniversity of Chicago
DepartmentMedicine-Pulmonary and Critical Care
AddressChicago IL 60637
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    R01LM014263     (William F Parker)Apr 1, 2023 - Jan 31, 2028
    NIH/NLM
    Improving the efficiency and equity of critical care allocation during a crisis with place-based disadvantage indices
    Role Description: When a US hospital system is overwhelmed by disaster, Crisis Standards of Care guide the triage teams forced to choose which patients receive scarce life support treatments in the Intensive Care Unit (ICU). Most US State Crisis Standards of Care rely on the Sequential Organ Failure Assessment (SOFA) score, but SOFA is inaccurate and racially biased. This project will 1) use structural equation modeling to develop an equitable life support allocation (ELSA) score with place-based disadvantage indices and 2) create the ICU Crisis Simulation Model (ICSM), open-source simulation software that evaluates the efficiency and equity of proposed life support allocation protocols.
    Role: Principal Investigator
    Making a Difference     (William F Parker)Jan 1, 2023 - Dec 31, 2024
    Greenwall Foundation
    Simulating Crisis Standards of Care and Developing an Equitable Life Support Allocation Protocol
    Role: Principal Investigator
    K08HL150291     (PARKER, WILLIAM F)Feb 1, 2020 - Jan 31, 2025
    NIH
    Mending a Broken Heart Allocation System with Machine Learning
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Adegunsoye A, Baccile R, Best TJ, Zaksas V, Zhang H, Karnik R, Patel BK, Solomonides AE, Parker WF, Solway J. Pharmacotherapy and pulmonary fibrosis risk after SARS-CoV-2 infection-response to Guangting Zeng and Yuchi Zhou. Lancet Reg Health Am. 2023 Oct; 26:100611. PMID: 37829195; PMCID: PMC10565760.
      Citations:    
    2. Piscitello GM, Parker WF. Do-Not-Resuscitate Orders by COVID-19 Status Throughout the First Year of the COVID-19 Pandemic. Chest. 2023 Sep 29. PMID: 37778695.
      Citations:    Fields:    
    3. Adegunsoye A, Baccile R, Best TJ, Zaksas V, Zhang H, Karnik R, Patel BK, Solomonides AE, Parker WF, Solway J, N3C Consortium. Pharmacotherapy and pulmonary fibrosis risk after SARS-CoV-2 infection: a prospective nationwide cohort study in the United States. Lancet Reg Health Am. 2023 Sep; 25:100566. PMID: 37564420; PMCID: PMC10410516.
      Citations: 3     
    4. Derman BA, Parker WF. Fair Allocation of Scarce CAR T-Cell Therapies for Relapsed/Refractory Multiple Myeloma. JAMA. 2023 Jul 31. PMID: 37523170.
      Citations:    Fields:    
    5. Ahn DJ, Zeng S, Pelzer KM, Barth RN, Gallo A, Parker WF. The Accuracy of Nonstandardized MELD/PELD Score Exceptions in the Pediatric Liver Allocation System. Transplantation. 2023 10 01; 107(10):e247-e256. PMID: 37408100; PMCID: PMC10527428.
      Citations:    Fields:    Translation:Humans
    6. Johnson DY, Ahn D, Lazenby K, Zeng S, Zhang K, Narang N, Khush K, Parker WF. Association of high-priority exceptions with waitlist mortality among heart transplant candidates. J Heart Lung Transplant. 2023 09; 42(9):1175-1182. PMID: 37225029; PMCID: PMC10524782.
      Citations:    Fields:    Translation:Humans
    7. Marcinak CT, Parker WF, Parikh AA, Datta J, Maithel SK, Kooby DA, Burkard ME, Kim HJ, LeCompte MT, Afshar M, Churpek MM, Zafar SN. Accuracy of models to prognosticate survival after surgery for pancreatic cancer in the era of neoadjuvant therapy. J Surg Oncol. 2023 Aug; 128(2):280-288. PMID: 37073788; PMCID: PMC10330210.
      Citations:    Fields:    Translation:Humans
    8. Pelzer KM, Zhang KC, Lazenby KA, Narang N, Churpek MM, Anderson AS, Parker WF. The Accuracy of Initial U.S. Heart Transplant Candidate Rankings. JACC Heart Fail. 2023 05; 11(5):504-512. PMID: 37052549.
      Citations:    Fields:    Translation:Humans
    9. Khush KK, Sandhu AT, Parker WF. How to Make the Transplantation Allocation System Better. JACC Heart Fail. 2023 05; 11(5):516-519. PMID: 37137658.
      Citations:    Fields:    Translation:Humans
    10. Piscitello GM, Tyker A, Schenker Y, Arnold RM, Siegler M, Parker WF. Disparities in Unilateral Do Not Resuscitate Order Use During the COVID-19 Pandemic. Crit Care Med. 2023 Aug 01; 51(8):1012-1022. PMID: 36995088; PMCID: PMC10526631.
      Citations:    Fields:    Translation:HumansPHPublic Health
    11. Plana A, Belkin MN, Kanelidis AJ, Parker WF, Jeevanandam V, Salerno C, Nguyen AB, Chung BB, Smith BA, Kalantari S, Sarswat N, Kim G, Pinney SP, Grinstein J. Status One and Status Two Exception Use in the Updated Heart Allocation System. J Card Fail. 2023 Jun; 29(6):963-967. PMID: 36966881.
      Citations:    Fields:    Translation:Humans
    12. Jablonski R, Parker WF. Inaccurate Predictions in Lung Transplantation and Implications for Allocation Policy. Chest. 2023 01; 163(1):16-17. PMID: 36628665.
      Citations:    Fields:    Translation:Humans
    13. Chung K, Parker WF. A bridge to nowhere: The durable left ventricular assist device dilemma in the new heart allocation system. J Heart Lung Transplant. 2022 Oct 29. PMID: 36437169.
      Citations:    Fields:    
    14. Strohbehn G, Persad G, Parker WF, Murthy S. Dose optimisation and scarce resource allocation: two sides of the same coin. BMJ Open. 2022 10 12; 12(10):e063436. PMID: 36223969; PMCID: PMC9562718.
      Citations: 2     Fields:    Translation:HumansPHPublic Health
    15. Parker WF, Persad G, Peek ME. Errors in Converting Principles to Protocols: Where the Bioethics of U.S. Covid-19 Vaccine Allocation Went Wrong. Hastings Cent Rep. 2022 09; 52(5):8-14. PMID: 36226880; PMCID: PMC9827540.
      Citations: 1     Fields:    Translation:HumansPHPublic Health
    16. Narang N, Thibodeau JT, Parker WF, Grodin JL, Garg S, Tedford RJ, Levine BD, McGuire DK, Drazner MH. Comparison of Accuracy of Estimation of Cardiac Output by Thermodilution Versus the Fick Method Using Measured Oxygen Uptake. Am J Cardiol. 2022 08 01; 176:58-65. PMID: 35613956; PMCID: PMC9648100.
      Citations:    Fields:    Translation:Humans
    17. Dussault NE, Churpek MM, Parker WF. Is it too soon to abandon all hope of useful post-transplant predictions in thoracic transplantation? Reply to: Expecting the unexpected, and prioritizing the predictable. J Heart Lung Transplant. 2022 09; 41(9):1304. PMID: 35835679; PMCID: PMC9661525.
      Citations:    Fields:    
    18. Zeng S, Pelzer KM, Gibbons RD, Peek ME, Parker WF. Association of Zip Code Vaccination Rate With COVID-19 Mortality in Chicago, Illinois. JAMA Netw Open. 2022 05 02; 5(5):e2214753. PMID: 35622360; PMCID: PMC9142872.
      Citations: 6     Fields:    Translation:HumansPHPublic Health
    19. Parker WF. Caring for the Unvaccinated. Ann Am Thorac Soc. 2022 02; 19(2):153-156. PMID: 34860642; PMCID: PMC8867358.
      Citations: 2     Fields:    Translation:HumansPHPublic Health
    20. Bhavani SV, Verhoef PA, Maier CL, Robichaux C, Parker WF, Holder A, Kamaleswaran R, Wang MD, Churpek MM, Coopersmith CM. Coronavirus Disease 2019 Temperature Trajectories Correlate With Hyperinflammatory and Hypercoagulable Subphenotypes. Crit Care Med. 2022 02 01; 50(2):212-223. PMID: 35100194; PMCID: PMC8796835.
      Citations: 5     Fields:    Translation:HumansCells
    21. Lazenby KA, Narang N, Pelzer KM, Ran G, Parker WF. An updated estimate of posttransplant survival after implementation of the new donor heart allocation policy. Am J Transplant. 2022 06; 22(6):1683-1690. PMID: 34951528; PMCID: PMC9177535.
      Citations: 6     Fields:    Translation:Humans
    22. Piscitello GM, Siegler M, Parker WF. Ethics of Extracorporeal Membrane Oxygenation under Conventional and Crisis Standards of Care. J Clin Ethics. 2022; 33(1):13-22. PMID: 35100174; PMCID: PMC9648099.
      Citations: 1     Fields:    Translation:Humans
    23. Han X, Davis AM, Parker WF. Managing Adult Acute and Acute-on-Chronic Liver Failure in the ICU. JAMA. 2021 Nov 16; 326(19):1964-1965. PMID: 34783852; PMCID: PMC9648071.
      Citations: 3     Fields:    Translation:Humans
    24. Bhavani SV, Luo Y, Miller WD, Sanchez-Pinto LN, Han X, Mao C, Peek ME, Coopersmith CM, Michelson KN, Parker WF, Sandikçi B. Simulation of Ventilator Allocation in Critically Ill Patients with COVID-19. Am J Respir Crit Care Med. 2021 11 15; 204(10):1224-1227. PMID: 34499587; PMCID: PMC8759315.
      Citations: 6     Fields:    Translation:Humans
    25. Parker WF, Dussault NE, Jablonski R, Garrity ER, Churpek MM. Assessing the accuracy of the lung allocation score. J Heart Lung Transplant. 2022 02; 41(2):217-225. PMID: 34802876; PMCID: PMC8799497.
      Citations: 4     Fields:    Translation:Humans
    26. Gandhi R, Piscitello GM, Parker WF, Michelson K. Variation in COVID-19 Resource Allocation Protocols and Potential Implementation in the Chicago Metropolitan Area. AJOB Empir Bioeth. 2021 Oct-Dec; 12(4):266-275. PMID: 34596474; PMCID: PMC9648102.
      Citations: 2     Fields:    Translation:HumansCellsPHPublic Health
    27. Piscitello GM, Bermea RS, Stokes JW, Gannon WD, Kanelidis AJ, Konopka M, Shappell C, Frye LK, Lyons PG, Siegler M, Parker WF. Clinician Ethical Perspectives on Extracorporeal Membrane Oxygenation in Practice. Am J Hosp Palliat Care. 2022 Jun; 39(6):659-666. PMID: 34414798; PMCID: PMC8858336.
      Citations: 2     Fields:    Translation:Humans
    28. Churpek MM, Gupta S, Spicer AB, Parker WF, Fahrenbach J, Brenner SK, Leaf DE, STOP-COVID Investigators. Hospital-Level Variation in Death for Critically Ill Patients with COVID-19. Am J Respir Crit Care Med. 2021 08 15; 204(403-411). PMID: 33891529; PMCID: PMC8480242.
      Citations: 23     Fields:    Translation:HumansCells
    29. Strohbehn GW, Parker WF, Reid PD, Gellad WF. Socially optimal pandemic drug dosing. Lancet Glob Health. 2021 08; 9(8):e1049-e1050. PMID: 34139194; PMCID: PMC8203182.
      Citations: 4     Fields:    Translation:Humans
    30. Miller WD, Han X, Peek ME, Charan Ashana D, Parker WF. Accuracy of the Sequential Organ Failure Assessment Score for In-Hospital Mortality by Race and Relevance to Crisis Standards of Care. JAMA Netw Open. 2021 06 01; 4(6):e2113891. PMID: 34143190; PMCID: PMC8214156.
      Citations: 14     Fields:    Translation:Humans
    31. Ran G, Chung K, Anderson AS, Gibbons RD, Narang N, Churpek MM, Parker WF. Between-center variation in high-priority listing status under the new heart allocation policy. Am J Transplant. 2021 11; 21(11):3684-3693. PMID: 33864733; PMCID: PMC8729112.
      Citations: 5     Fields:    Translation:Humans
    32. Parker WF, Persad G, Peek ME. Fair Allocation at COVID-19 Mass Vaccination Sites. JAMA Health Forum. 2021 Apr 01; 2(4):e210464. PMID: 36218803.
      Citations: 3     Fields:    
    33. Sanchez-Pinto LN, Parker WF, Mayampurath A, Derrington S, Michelson KN. Evaluation of Organ Dysfunction Scores for Allocation of Scarce Resources in Critically Ill Children and Adults During a Healthcare Crisis. Crit Care Med. 2021 02 01; 49(2):271-281. PMID: 33351501; PMCID: PMC8030729.
      Citations: 4     Fields:    Translation:Humans
    34. Peek ME, Simons RA, Parker WF, Ansell DA, Rogers SO, Edmonds BT. COVID-19 Among African Americans: An Action Plan for Mitigating Disparities. Am J Public Health. 2021 02; 111(2):286-292. PMID: 33351662; PMCID: PMC7811104.
      Citations: 27     Fields:    Translation:Humans
    35. Piscitello GM, Kapania EM, Kanelidis A, Siegler M, Parker WF. The Use of Slow Codes and Medically Futile Codes in Practice. J Pain Symptom Manage. 2021 08; 62(2):326-335.e5. PMID: 33346066; PMCID: PMC8729118.
      Citations: 2     Fields:    Translation:Humans
    36. Parker WF, Chung K, Anderson AS, Siegler M, Huang ES, Churpek MM. Practice Changes at U.S. Transplant Centers After the New Adult Heart Allocation Policy. J Am Coll Cardiol. 2020 06 16; 75(23):2906-2916. PMID: 32527399; PMCID: PMC7304520.
      Citations: 20     Fields:    Translation:Humans
    37. Piscitello GM, Kapania EM, Miller WD, Rojas JC, Siegler M, Parker WF. Variation in Ventilator Allocation Guidelines by US State During the Coronavirus Disease 2019 Pandemic: A Systematic Review. JAMA Netw Open. 2020 06 01; 3(6):e2012606. PMID: 32558916; PMCID: PMC7305526.
      Citations: 45     Fields:    Translation:HumansCellsPHPublic Health
    38. Miller WD, Peek ME, Parker WF. Scarce Resource Allocation Scores Threaten to Exacerbate Racial Disparities in Health Care. Chest. 2020 10; 158(4):1332-1334. PMID: 32450243; PMCID: PMC7243750.
      Citations: 6     Fields:    Translation:Humans
    39. Parker WF, Chin MH. Epistemic Authority and Trust in Shared Decision Making About Organ Transplantation. AMA J Ethics. 2020 05 01; 22(5):E408-415. PMID: 32449657; PMCID: PMC7565084.
      Citations:    Fields:    Translation:Humans
    40. Espinosa ML, Tannenbaum AM, Kilaru M, Stevens J, Siegler M, Howell MD, Parker WF. Bundled Consent in US Intensive Care Units. Am J Crit Care. 2020 05 01; 29(3):e44-e51. PMID: 32355968; PMCID: PMC7565087.
      Citations: 1     Fields:    Translation:Humans
    41. Pearson SD, Hall JB, Parker WF. Two for one with split- or co-ventilation at the peak of the COVID-19 tsunami: is there any role for communal care when the resources for personalised medicine are exhausted? Thorax. 2020 06; 75(6):444-445. PMID: 32327565; PMCID: PMC7675921.
      Citations: 3     Fields:    Translation:HumansCellsPHPublic Health
    42. Parker WF, Churpek MM, Anderson AS. Is it too early to investigate survival outcomes of the new US heart allocation system? J Heart Lung Transplant. 2020 07; 39(7):726. PMID: 32037250; PMCID: PMC7565081.
      Citations: 5     Fields:    Translation:Humans
    43. Parker WF, Anderson AS, Gibbons RD, Garrity ER, Ross LF, Huang ES, Churpek MM. Association of Transplant Center With Survival Benefit Among Adults Undergoing Heart Transplant in the United States. JAMA. 2019 11 12; 322(18):1789-1798. PMID: 31714985; PMCID: PMC6865773.
      Citations: 6     Fields:    Translation:Humans
    44. Piscitello GM, Parham WM, Huber MT, Siegler M, Parker WF. The Timing of Family Meetings in the Medical Intensive Care Unit. Am J Hosp Palliat Care. 2019 Dec; 36(12):1049-1056. PMID: 30983374; PMCID: PMC7565097.
      Citations: 5     Fields:    Translation:Humans
    45. Parker WF, Anderson AS, Huang ES, Garrity ER, Churpek MM. Reply: Does Overtreatment of Heart Transplantation Candidates Exist? J Am Coll Cardiol. 2018 08 07; 72(6):703-704. PMID: 30072009; PMCID: PMC6642804.
      Citations:    Fields:    Translation:Humans
    46. Parker WF, Gorges RJ, Gao YN, Zhang Y, Hur K, Gibbons RD. Association Between Groundwater Lithium and the Diagnosis of Bipolar Disorder and Dementia in the United States. JAMA Psychiatry. 2018 07 01; 75(7):751-754. PMID: 29799907; PMCID: PMC6145675.
      Citations: 5     Fields:    Translation:Humans
    47. Gallo AE, Parker WF, Thistlethwaite JR, Ross LF. It is time to revise the kidney allocation system to restore the pediatric advantage. Am J Transplant. 2018 09; 18(9):2365-2366. PMID: 29706006; PMCID: PMC6117209.
      Citations: 4     Fields:    Translation:Humans
    48. Parker WF, Anderson AS, Hedeker D, Huang ES, Garrity ER, Siegler M, Churpek MM. Geographic Variation in the Treatment of U.S. Adult Heart Transplant Candidates. J Am Coll Cardiol. 2018 04 24; 71(16):1715-1725. PMID: 29666020; PMCID: PMC6019274.
      Citations: 9     Fields:    Translation:Humans
    49. Parker WF, Ross LF, Richard Thistlethwaite J, Gallo AE. Impact of the kidney allocation system on young pediatric recipients. Clin Transplant. 2018 04; 32(4):e13223. PMID: 29457274; PMCID: PMC6029615.
      Citations: 10     Fields:    Translation:Humans
    50. Parker WF, Garrity ER, Fedson S, Churpek MM. Trends in the Use of Inotropes to List Adult Heart Transplant Candidates at Status 1A. Circ Heart Fail. 2017 Dec; 10(12). PMID: 29246896; PMCID: PMC5739062.
      Citations: 5     Fields:    Translation:Humans
    51. Parker WF, Garrity ER, Fedson S, Churpek MM. Potential impact of a shock requirement on adult heart allocation. J Heart Lung Transplant. 2017 09; 36(9):1013-1016. PMID: 28579114; PMCID: PMC6060413.
      Citations: 7     Fields:    Translation:Humans
    52. Parker WF, Thistlethwaite JR, Ross LF. Kidney Donor Profile Index Does Not Accurately Predict the Graft Survival of Pediatric Deceased Donor Kidneys. Transplantation. 2016 Nov; 100(11):2471-2478. PMID: 26760565; PMCID: PMC4940335.
      Citations: 13     Fields:    Translation:Humans
    53. Roll GR, Parekh JR, Parker WF, Siegler M, Pomfret EA, Ascher NL, Roberts JP. Left hepatectomy versus right hepatectomy for living donor liver transplantation: shifting the risk from the donor to the recipient. Liver Transpl. 2013 May; 19(5):472-81. PMID: 23447523.
      Citations: 24     Fields:    Translation:Humans
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