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Nathan Schoettler

TitleAssistant Professor
InstitutionUniversity of Chicago
DepartmentMedicine-Pulmonary and Critical Care
AddressChicago IL 60637
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    Collapse Biography 
    Collapse education and training
    University of Chicago, Chicago, ILPostdoctoral research06/2019Human Genetics
    University of Chicago, Chicago, ILMD06/2012Medicine
    University of Chicago, Chicago, ILPhD12/2009Immunology
    University of California, Los Angeles, Los Angeles, CAMS06/2003Molecular, Cellular and Developmental Biology

    Collapse Research 
    Collapse research activities and funding
    K08HL153955     (SCHOETTLER, NATHAN R)Aug 15, 2020 - Jul 31, 2025
    NIH
    Genetics of Asthma Sub-Phenotypes Impact Gene Regulation in Cell-Specific Patterns
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Dapas M, Lee YL, Wentworth-Sheilds W, Im HK, Ober C, Schoettler N. Revealing polygenic pleiotropy using genetic risk scores for asthma. HGG Adv. 2023 10 12; 4(4):100233. PMID: 37663543; PMCID: PMC10474095.
      Citations: 1     Translation:Humans
    2. Jia G, Zhong X, Im HK, Schoettler N, Pividori M, Hogarth DK, Sperling AI, White SR, Naureckas ET, Lyttle CS, Terao C, Kamatani Y, Akiyama M, Matsuda K, Kubo M, Cox NJ, Ober C, Rzhetsky A, Solway J. Discerning asthma endotypes through comorbidity mapping. Nat Commun. 2022 11 07; 13(1):6712. PMID: 36344522; PMCID: PMC9640644.
      Citations: 2     Fields:    Translation:Humans
    3. Schoettler N, Dissanayake E, Craven MW, Yee JS, Eliason J, Schauberger EM, Lemanske RF, Ober C, Gern JE. New Insights Relating Gasdermin B to the Onset of Childhood Asthma. Am J Respir Cell Mol Biol. 2022 Oct; 67(4):430-437. PMID: 35580164; PMCID: PMC9564923.
      Citations: 3     Fields:    Translation:Humans
    4. Clay SM, Schoettler N, Goldstein AM, Carbonetto P, Dapas M, Altman MC, Rosasco MG, Gern JE, Jackson DJ, Im HK, Stephens M, Nicolae DL, Ober C. Fine-mapping studies distinguish genetic risks for childhood- and adult-onset asthma in the HLA region. Genome Med. 2022 05 24; 14(1):55. PMID: 35606880; PMCID: PMC9128203.
      Citations: 1     Fields:    Translation:HumansCells
    5. Aneas I, Decker DC, Howard CL, Sakabe NJ, Blaine KM, Stein MM, Hrusch CL, Montefiori LE, Magnaye KM, Clay SM, Gern JE, Jackson DJ, Altman MC, Naureckas ET, Hogarth DK, White SR, Schoetler N, Ober C, Sperling AI, Sobreira DR, Tena J, Gomez-Skarmeta JL, Nóbrega MA. Asthma-associated genetic variants induce IL33 differential expression through an enhancer-blocking regulatory region. Nat Commun. 2021 10 21; 12(1):6115. PMID: 34675193; PMCID: PMC8531453.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    6. Wu D, Lee TH, Huang RT, D Guzy R, Schoettler N, Adegunsoye A, Mueller J, Husain A, I Sperling A, Fang Y, Mutlu GM. SARS-CoV-2 Infection Is Associated with Reduced Krüppel-like Factor 2 in Human Lung Autopsy. Am J Respir Cell Mol Biol. 2021 08; 65(2):222-226. PMID: 33971111; PMCID: PMC8399572.
      Citations: 3     Fields:    Translation:HumansCells
    7. Kim KW, Kim DY, Yoon D, Kim KK, Jang H, Schoettler N, Kim EG, Kim MN, Hong JY, Lee JK, Kim S, Ober C, Gee HY, Sohn MH. Genome-wide association study identifies TNFSF15 associated with childhood asthma. Allergy. 2022 01; 77(1):218-229. PMID: 34022066; PMCID: PMC8606614.
      Citations: 6     Fields:    Translation:Humans
    8. McMullen P, Pytel P, Snyder A, Smith H, Vickery J, Brainer J, Guzy R, Wu D, Schoettler N, Adegunsoye A, Sperling A, Hart J, Alpert L, Chang A, Gurbuxani S, Krausz T, Husain AN, Mueller J. A series of COVID-19 autopsies with clinical and pathologic comparisons to both seasonal and pandemic influenza. J Pathol Clin Res. 2021 09; 7(5):459-470. PMID: 33960723; PMCID: PMC8239851.
      Citations: 5     Fields:    Translation:HumansCellsPHPublic Health
    9. Lee TH, Wu D, Guzy R, Schoettler N, Adegunsoye A, Mueller J, Hussein A, Sperling A, Mutlu GM, Fang Y. SARS-CoV-2 infection reduces Krüppel-Like Factor 2 in human lung autopsy. bioRxiv. 2021 Jan 18. PMID: 33469586; PMCID: PMC7814823.
      Citations:    
    10. Schoettler N, Hrusch CL, Blaine KM, Sperling AI, Ober C. Transcriptional programming and T cell receptor repertoires distinguish human lung and lymph node memory T cells. Commun Biol. 2019; 2:411. PMID: 31754641; PMCID: PMC6853923.
      Citations: 8     Translation:HumansCells
    11. Schoettler N, Weidinger S, Ober C, Rodríguez E. Advances in asthma and allergic disease genetics: Is bigger always better? J Allergy Clin Immunol. 2019 12; 144(6):1495-1506. PMID: 31677964; PMCID: PMC6900451.
      Citations: 30     Fields:    Translation:Humans
    12. Schoettler N, Strek ME. Recent Advances in Severe Asthma: From Phenotypes to Personalized Medicine. Chest. 2020 03; 157(3):516-528. PMID: 31678077; PMCID: PMC7609962.
      Citations: 46     Fields:    Translation:HumansPHPublic Health
    13. Schoettler N, Ober C. Genetic architecture of moderate-to-severe asthma mirrors that of mild asthma. J Allergy Clin Immunol. 2019 12; 144(6):1521-1523. PMID: 31541629.
      Citations: 3     Fields:    Translation:Humans
    14. Pividori M, Schoettler N, Nicolae DL, Ober C, Im HK. Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies. Lancet Respir Med. 2019 06; 7(6):509-522. PMID: 31036433; PMCID: PMC6534440.
      Citations: 112     Fields:    Translation:HumansCells
    15. Waage J, Curtin JA, Jessen LE, Thorsen J, Tian C, Schoettler N, 23andMe Research Team, AAGC collaborators, Flores C, Abdellaoui A, Ahluwalia TS, Alves AC, Amaral AFS, Arnold A, Barreto-Luis A, van Beijsterveldt CEM, Bleecker ER, Boomsma DI, Brix S, Bunyavanich S, Burchard EG, Chen Z, Curjuric I, Custovic A, den Dekker HT, Dharmage SC, Duijts L, Ege MJ, Gauderman WJ, Gilliland F, Granell R, Gui H, Hansen T, Henderson J, Hernandez-Pacheco N, Holt P, Imboden M, Jaddoe VWV, Jarvelin MR, Jarvis DL, Jensen KK, Kabesch M, Kaprio J, Kumar A, Levin AM, Li X, Lorenzo-Diaz F, Mercader JM, Meyers DA, Myers R, Nicolae DL, Nohr EA, Palviainen T, Paternoster L, Pennell CE, Pino-Yanes M, Probst-Hensch NM, Simpson A, Stefansson K, Sunyer J, Sveinbjornsson G, Thompson PJ, Torrent M, Torrents D, Tung JY, Wang CA, Weidinger S, Weiss S, Willemsen G, Williams LK, Ober C, Hinds DA, Ferreira MA, Bisgaard H, Strachan DP, Standl M, Antó JM, Baurecht H, Bonàs-Guarch S, Dmitrieva J, Georges M, Gieger C, Heinrich J, Jónsdóttir I, Lee YA, Melén E, Pershagen G, Rüschendorf F, Thiering E, Bønnelykke K. Author Correction: Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis. Nat Genet. 2018 09; 50(9):1343. PMID: 30116036.
      Citations: 1     Fields:    
    16. Waage J, Curtin JA, Jessen LE, Thorsen J, Tian C, Schoettler N, 23andMe Research Team, AAGC collaborators, Flores C, Abdellaoui A, Ahluwalia TS, Alves AC, Amaral AFS, Arnold A, Barreto-Luis A, van Beijsterveldt CEM, Bleecker ER, Boomsma DI, Brix S, Bunyavanich S, Burchard EG, Chen Z, Curjuric I, Custovic A, den Dekker HT, Dharmage SC, Duijts L, Ege MJ, Gauderman WJ, Gilliland F, Granell R, Gui H, Hansen T, Henderson J, Hernandez-Pacheco N, Holt P, Imboden M, Jaddoe VWV, Jarvelin MR, Jarvis DL, Jensen KK, Kabesch M, Kaprio J, Kumar A, Levin AM, Li X, Lorenzo-Diaz F, Mercader JM, Meyers DA, Myers R, Nicolae DL, Nohr EA, Palviainen T, Paternoster L, Pennell CE, Pino-Yanes M, Probst-Hensch NM, Simpson A, Stefansson K, Sunyer J, Sveinbjornsson G, Thompson PJ, Torrent M, Torrents D, Tung JY, Wang CA, Weidinger S, Weiss S, Willemsen G, Williams LK, Ober C, Hinds DA, Ferreira MA, Bisgaard H, Strachan DP, Standl M, Antó JM, Baurecht H, Bonàs-Guarch S, Dmitrieva J, Georges M, Gieger C, Heinrich J, Jónsdóttir I, Lee YA, Melén E, Pershagen G, Rüschendorf F, Thiering E, Bønnelykke K. Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis. Nat Genet. 2018 08; 50(8):1072-1080. PMID: 30013184; PMCID: PMC7068780.
      Citations: 44     Fields:    Translation:Humans
    17. Stein MM, Thompson EE, Schoettler N, Helling BA, Magnaye KM, Stanhope C, Igartua C, Washington C, Nicolae D, Ober C, Morin A, Bønnelykke K. A decade of research on the 17q12-21 asthma locus: Piecing together the puzzle. J Allergy Clin Immunol. 2018 09; 142(3):749-764.e3. PMID: 29307657; PMCID: PMC6172038.
      Citations: 77     Fields:    Translation:HumansCells
    18. Schoettler N, Ni D, Weigert M. B cell receptor light chain repertoires show signs of selection with differences between groups of healthy individuals and SLE patients. Mol Immunol. 2012 Jul; 51(3-4):273-82. PMID: 22516082; PMCID: PMC4264353.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    19. Schoettler N, Brahn E. Angiogenesis inhibitors for the treatment of chronic autoimmune inflammatory arthritis. Curr Opin Investig Drugs. 2009 May; 10(5):425-33. PMID: 19431075.
      Citations: 4     Fields:    Translation:HumansAnimals
    20. Brahn E, Schoettler N, Lee S, Banquerigo ML. Involution of collagen-induced arthritis with an angiogenesis inhibitor, PPI-2458. J Pharmacol Exp Ther. 2009 May; 329(2):615-24. PMID: 19218530; PMCID: PMC2672877.
      Citations: 6     Fields:    Translation:AnimalsCells
    21. Pine PR, Chang B, Schoettler N, Banquerigo ML, Wang S, Lau A, Zhao F, Grossbard EB, Payan DG, Brahn E. Inflammation and bone erosion are suppressed in models of rheumatoid arthritis following treatment with a novel Syk inhibitor. Clin Immunol. 2007 Sep; 124(3):244-57. PMID: 17537677.
      Citations: 82     Fields:    Translation:AnimalsCells
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