 Lymphocyte Function-Associated Antigen-1
"Lymphocyte Function-Associated Antigen-1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An integrin heterodimer widely expressed on cells of hematopoietic origin. CD11A ANTIGEN comprises the alpha chain and the CD18 antigen (ANTIGENS, CD18) the beta chain. Lymphocyte function-associated antigen-1 is a major receptor of T-CELLS; B-CELLS; and GRANULOCYTES. It mediates the leukocyte adhesion reactions underlying cytolytic conjugate formation, helper T-cell interactions, and antibody-dependent killing by NATURAL KILLER CELLS and granulocytes. Intracellular adhesion molecule-1 has been defined as a ligand for lymphocyte function-associated antigen-1.
| Descriptor ID |
D016169
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| MeSH Number(s) |
D12.776.395.550.200.625.550 D12.776.543.550.200.625.550 D12.776.543.750.705.408.600.400 D12.776.543.750.705.877.550 D23.050.301.264.035.111.400 D23.050.301.264.035.850.550 D23.050.301.350.625.550 D23.101.100.110.111.400 D23.101.100.110.850.550
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| Concept/Terms |
Lymphocyte Function-Associated Antigen-1- Lymphocyte Function-Associated Antigen-1
- Antigen-1, Lymphocyte Function-Associated
- Leukocyte Function Associated Antigen-1
- LFA-1
- Integrin alphaLbeta2
- alphaLbeta2, Integrin
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Below are MeSH descriptors whose meaning is more general than "Lymphocyte Function-Associated Antigen-1".
- Chemicals and Drugs [D]
- Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
- Glycoproteins [D12.776.395]
- Membrane Glycoproteins [D12.776.395.550]
- Cell Adhesion Molecules [D12.776.395.550.200]
- Receptors, Lymphocyte Homing [D12.776.395.550.200.625]
- Lymphocyte Function-Associated Antigen-1 [D12.776.395.550.200.625.550]
- Membrane Proteins [D12.776.543]
- Membrane Glycoproteins [D12.776.543.550]
- Cell Adhesion Molecules [D12.776.543.550.200]
- Receptors, Lymphocyte Homing [D12.776.543.550.200.625]
- Lymphocyte Function-Associated Antigen-1 [D12.776.543.550.200.625.550]
- Receptors, Cell Surface [D12.776.543.750]
- Receptors, Immunologic [D12.776.543.750.705]
- Integrins [D12.776.543.750.705.408]
- Receptors, Leukocyte-Adhesion [D12.776.543.750.705.408.600]
- Lymphocyte Function-Associated Antigen-1 [D12.776.543.750.705.408.600.400]
- Receptors, Lymphocyte Homing [D12.776.543.750.705.877]
- Lymphocyte Function-Associated Antigen-1 [D12.776.543.750.705.877.550]
- Biological Factors [D23]
- Antigens [D23.050]
- Antigens, Surface [D23.050.301]
- Antigens, Differentiation [D23.050.301.264]
- Antigens, CD [D23.050.301.264.035]
- Antigens, CD11 [D23.050.301.264.035.111]
- Lymphocyte Function-Associated Antigen-1 [D23.050.301.264.035.111.400]
- Receptors, Lymphocyte Homing [D23.050.301.264.035.850]
- Lymphocyte Function-Associated Antigen-1 [D23.050.301.264.035.850.550]
- Cell Adhesion Molecules [D23.050.301.350]
- Receptors, Lymphocyte Homing [D23.050.301.350.625]
- Lymphocyte Function-Associated Antigen-1 [D23.050.301.350.625.550]
- Biological Markers [D23.101]
- Antigens, Differentiation [D23.101.100]
- Antigens, CD [D23.101.100.110]
- Antigens, CD11 [D23.101.100.110.111]
- Lymphocyte Function-Associated Antigen-1 [D23.101.100.110.111.400]
- Receptors, Lymphocyte Homing [D23.101.100.110.850]
- Lymphocyte Function-Associated Antigen-1 [D23.101.100.110.850.550]
Below are MeSH descriptors whose meaning is more specific than "Lymphocyte Function-Associated Antigen-1".
This graph shows the total number of publications written about "Lymphocyte Function-Associated Antigen-1" by people in this website by year, and whether "Lymphocyte Function-Associated Antigen-1" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1991 | 0 | 1 | 1 | | 1992 | 1 | 1 | 2 | | 1993 | 0 | 2 | 2 | | 1994 | 0 | 1 | 1 | | 1995 | 1 | 0 | 1 | | 2001 | 0 | 1 | 1 | | 2002 | 0 | 1 | 1 | | 2011 | 1 | 0 | 1 | | 2014 | 0 | 1 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Lymphocyte Function-Associated Antigen-1" by people in Profiles.
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Sladojevic N, Stamatovic SM, Keep RF, Grailer JJ, Sarma JV, Ward PA, Andjelkovic AV. Inhibition of junctional adhesion molecule-A/LFA interaction attenuates leukocyte trafficking and inflammation in brain ischemia/reperfusion injury. Neurobiol Dis. 2014 Jul; 67:57-70.
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Thomas SY, Scanlon ST, Griewank KG, Constantinides MG, Savage AK, Barr KA, Meng F, Luster AD, Bendelac A. PLZF induces an intravascular surveillance program mediated by long-lived LFA-1-ICAM-1 interactions. J Exp Med. 2011 Jun 06; 208(6):1179-88.
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Marski M, Kandula S, Turner JR, Abraham C. CD18 is required for optimal development and function of CD4+CD25+ T regulatory cells. J Immunol. 2005 Dec 15; 175(12):7889-97.
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Huang J, Lo PF, Zal T, Gascoigne NR, Smith BA, Levin SD, Grey HM. CD28 plays a critical role in the segregation of PKC theta within the immunologic synapse. Proc Natl Acad Sci U S A. 2002 Jul 09; 99(14):9369-73.
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Sato M, Chamoto K, Tsuji T, Iwakura Y, Togashi Y, Koda T, Nishimura T. Th1 cytokine-conditioned bone marrow-derived dendritic cells can bypass the requirement for Th functions during the generation of CD8+ CTL. J Immunol. 2001 Oct 01; 167(7):3687-91.
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Hmama Z, Knutson KL, Herrera-Velit P, Nandan D, Reiner NE. Monocyte adherence induced by lipopolysaccharide involves CD14, LFA-1, and cytohesin-1. Regulation by Rho and phosphatidylinositol 3-kinase. J Biol Chem. 1999 Jan 08; 274(2):1050-7.
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Edwards BS, Curry MS, Southon EA, Chong AS, Graf LH. Evidence for a dithiol-activated signaling pathway in natural killer cell avidity regulation of leukocyte function antigen-1: structural requirements and relationship to phorbol ester- and CD16-triggered pathways. Blood. 1995 Sep 15; 86(6):2288-301.
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Herold KC, Vezys V, Gage A, Montag AG. Prevention of autoimmune diabetes by treatment with anti-LFA-1 and anti-ICAM-1 monoclonal antibodies. Cell Immunol. 1994 Sep; 157(2):489-500.
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Chong AS, Boussy IA, Jiang XL, Lamas M, Graf LH. CD54/ICAM-1 is a costimulator of NK cell-mediated cytotoxicity. Cell Immunol. 1994 Aug; 157(1):92-105.
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Reder AT, Lascola CD, Flanders SA, Maimone D, Jensen MA, Skias DD, Lancki DW. Astrocyte cytolysis by MHC class II-specific mouse T cell clones. Transplantation. 1993 Aug; 56(2):393-9.
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