A novel interplay between Epac/Rap1 and mitogen-activated protein kinase kinase 5/extracellular signal-regulated kinase 5 (MEK5/ERK5) regulates thrombospondin to control angiogenesis.

A novel interplay between Epac/Rap1 and mitogen-activated protein kinase kinase 5/extracellular signal-regulated kinase 5 (MEK5/ERK5) regulates thrombospondin to control angiogenesis. Blood. 2009 Nov 12; 114(20):4592-600.

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subject areas

Animals
Blotting, Western
Endothelial Cells
Guanine Nucleotide Exchange Factors
Humans
Inhibitor of Differentiation Protein 1
MAP Kinase Kinase 5
Mice
Mice, Nude
Mitogen-Activated Protein Kinase 7
Neovascularization, Pathologic
rap1 GTP-Binding Proteins
Signal Transduction
Thrombospondins
Transfection

authors with profiles

Mark W. Lingen
Alexandre Chlenski
Mark Abe
Marsha Rosner