Alternative Splicing
"Alternative Splicing" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A process whereby multiple RNA transcripts are generated from a single gene. Alternative splicing involves the splicing together of other possible sets of EXONS during the processing of some, but not all, transcripts of the gene. Thus a particular exon may be connected to any one of several alternative exons to form a mature RNA. The alternative forms of mature MESSENGER RNA produce PROTEIN ISOFORMS in which one part of the isoforms is common while the other parts are different.
Descriptor ID |
D017398
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MeSH Number(s) |
G02.111.087.750.700.100 G02.149.115.750.700.100 G03.495.839.700.100 G05.355.315.700.700.100
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Concept/Terms |
Alternative Splicing- Alternative Splicing
- Alternative Splicings
- Splicings, Alternative
- Alternate Splicing
- Alternate Splicings
- Splicing, Alternate
- Splicings, Alternate
- RNA Splicing, Alternative
- Alternative RNA Splicing
- Alternative RNA Splicings
- RNA Splicings, Alternative
- Splicing, Alternative RNA
- Splicings, Alternative RNA
- Splicing, Alternative
Nested Transcripts- Nested Transcripts
- Nested Transcript
- Transcript, Nested
- Transcripts, Nested
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Below are MeSH descriptors whose meaning is more general than "Alternative Splicing".
Below are MeSH descriptors whose meaning is more specific than "Alternative Splicing".
This graph shows the total number of publications written about "Alternative Splicing" by people in this website by year, and whether "Alternative Splicing" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
Year | Major Topic | Minor Topic | Total |
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1993 | 1 | 0 | 1 | 1994 | 1 | 2 | 3 | 1995 | 0 | 5 | 5 | 1996 | 3 | 2 | 5 | 1997 | 1 | 3 | 4 | 1998 | 0 | 4 | 4 | 1999 | 2 | 1 | 3 | 2000 | 3 | 4 | 7 | 2001 | 2 | 4 | 6 | 2002 | 2 | 7 | 9 | 2003 | 1 | 5 | 6 | 2004 | 4 | 3 | 7 | 2005 | 0 | 6 | 6 | 2006 | 2 | 3 | 5 | 2007 | 5 | 6 | 11 | 2008 | 1 | 8 | 9 | 2009 | 6 | 2 | 8 | 2010 | 2 | 1 | 3 | 2011 | 0 | 1 | 1 | 2012 | 3 | 2 | 5 | 2013 | 0 | 1 | 1 | 2014 | 4 | 1 | 5 | 2015 | 2 | 4 | 6 | 2016 | 6 | 2 | 8 | 2017 | 1 | 4 | 5 | 2018 | 2 | 1 | 3 | 2019 | 3 | 1 | 4 | 2020 | 0 | 3 | 3 |
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Below are the most recent publications written about "Alternative Splicing" by people in Profiles.
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Li J, Xie Y, Cornelius S, Jiang X, Sando R, Kordon SP, Pan M, Leon K, Südhof TC, Zhao M, Araç D. Alternative splicing controls teneurin-latrophilin interaction and synapse specificity by a shape-shifting mechanism. Nat Commun. 2020 05 01; 11(1):2140.
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Leon K, Cunningham RL, Riback JA, Feldman E, Li J, Sosnick TR, Zhao M, Monk KR, Araç D. Structural basis for adhesion G protein-coupled receptor Gpr126 function. Nat Commun. 2020 01 10; 11(1):194.
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Shah A, Li YI. Identification and Quantification of Splicing Quantitative Trait Loci. Methods Mol Biol. 2020; 2082:51-62.
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Sulakhe D, D'Souza M, Wang S, Balasubramanian S, Athri P, Xie B, Canzar S, Agam G, Gilliam TC, Maltsev N. Exploring the functional impact of alternative splicing on human protein isoforms using available annotation sources. Brief Bioinform. 2019 09 27; 20(5):1754-1768.
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Zhou KI, Shi H, Lyu R, Wylder AC, Matuszek Z, Pan JN, He C, Parisien M, Pan T. Regulation of Co-transcriptional Pre-mRNA Splicing by m6A through the Low-Complexity Protein hnRNPG. Mol Cell. 2019 10 03; 76(1):70-81.e9.
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Upadhyay U, Zhuang GZ, Diatchenko L, Parisien M, Kang Y, Sarantopoulos KD, Martin ER, Smith SB, Maixner W, Levitt RC. Profound analgesia is associated with a truncated peptide resulting from tissue specific alternative splicing of DRG CA8-204 regulated by an exon-level cis-eQTL. PLoS Genet. 2019 06; 15(6):e1008226.
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Fica SM, Oubridge C, Wilkinson ME, Newman AJ, Nagai K. A human postcatalytic spliceosome structure reveals essential roles of metazoan factors for exon ligation. Science. 2019 02 15; 363(6428):710-714.
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Ye CJ, Chen J, Villani AC, Gate RE, Subramaniam M, Bhangale T, Lee MN, Raj T, Raychowdhury R, Li W, Rogel N, Simmons S, Imboywa SH, Chipendo PI, McCabe C, Lee MH, Frohlich IY, Stranger BE, De Jager PL, Regev A, Behrens T, Hacohen N. Genetic analysis of isoform usage in the human anti-viral response reveals influenza-specific regulation of ERAP2 transcripts under balancing selection. Genome Res. 2018 12; 28(12):1812-1825.
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Krishnaswamy S, Bukhari I, Mohammed AK, Amer OE, Tripathi G, Alokail MS, Al-Daghri NM. Identification of the splice variants of Recepteur d'Origine nantais (RON) in lung cancer cell lines. Gene. 2018 Dec 30; 679:335-340.
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Piltonen M, Parisien M, Grégoire S, Chabot-Doré AJ, Jafarnejad SM, Bérubé P, Djambazian H, Sladek R, Geneau G, Willett P, Stone LS, Shabalina SA, Diatchenko L. Alternative Splicing of the Delta-Opioid Receptor Gene Suggests Existence of New Functional Isoforms. Mol Neurobiol. 2019 Apr; 56(4):2855-2869.
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