"Alternative Splicing" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A process whereby multiple RNA transcripts are generated from a single gene. Alternative splicing involves the splicing together of other possible sets of EXONS during the processing of some, but not all, transcripts of the gene. Thus a particular exon may be connected to any one of several alternative exons to form a mature RNA. The alternative forms of mature MESSENGER RNA produce PROTEIN ISOFORMS in which one part of the isoforms is common while the other parts are different.
Descriptor ID |
D017398
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MeSH Number(s) |
G02.111.760.700.100 G03.839.700.100 G05.308.700.700.100
|
Concept/Terms |
Alternative Splicing- Alternative Splicing
- Alternative Splicings
- Splicings, Alternative
- Alternate Splicing
- Alternate Splicings
- Splicing, Alternate
- Splicings, Alternate
- RNA Splicing, Alternative
- Alternative RNA Splicing
- Alternative RNA Splicings
- RNA Splicings, Alternative
- Splicing, Alternative RNA
- Splicings, Alternative RNA
- Splicing, Alternative
Nested Transcripts- Nested Transcripts
- Nested Transcript
- Transcript, Nested
- Transcripts, Nested
|
Below are MeSH descriptors whose meaning is more general than "Alternative Splicing".
Below are MeSH descriptors whose meaning is more specific than "Alternative Splicing".
This graph shows the total number of publications written about "Alternative Splicing" by people in this website by year, and whether "Alternative Splicing" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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1994 | 1 | 2 | 3 |
1995 | 0 | 5 | 5 |
1996 | 1 | 2 | 3 |
1997 | 1 | 3 | 4 |
1998 | 0 | 4 | 4 |
1999 | 2 | 2 | 4 |
2000 | 3 | 4 | 7 |
2001 | 2 | 5 | 7 |
2002 | 2 | 7 | 9 |
2003 | 1 | 4 | 5 |
2004 | 3 | 3 | 6 |
2005 | 0 | 6 | 6 |
2006 | 2 | 3 | 5 |
2007 | 5 | 6 | 11 |
2008 | 1 | 7 | 8 |
2009 | 6 | 3 | 9 |
2010 | 2 | 2 | 4 |
2011 | 0 | 1 | 1 |
2012 | 3 | 2 | 5 |
2013 | 0 | 1 | 1 |
2014 | 4 | 1 | 5 |
2015 | 3 | 4 | 7 |
2016 | 6 | 2 | 8 |
2017 | 2 | 4 | 6 |
2018 | 4 | 1 | 5 |
2019 | 3 | 2 | 5 |
2020 | 3 | 5 | 8 |
2021 | 0 | 2 | 2 |
2022 | 1 | 0 | 1 |
2023 | 2 | 1 | 3 |
2024 | 2 | 0 | 2 |
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Below are the most recent publications written about "Alternative Splicing" by people in Profiles.
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Global impact of unproductive splicing on human gene expression. Nat Genet. 2024 Sep; 56(9):1851-1861.
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Alternative Splicing of RNA Is Excessive in Multiple Sclerosis and Not Linked to Gene Expression Levels: Dysregulation Is Corrected by IFN-ß. J Interferon Cytokine Res. 2024 08; 44(8):355-371.
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Single-cell long-read sequencing in human cerebral organoids uncovers cell-type-specific and autism-associated exons. Cell Rep. 2023 11 28; 42(11):113335.
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Alternative mRNA Splicing and Promising Therapies in Cancer. Biomolecules. 2023 03 20; 13(3).
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Upregulation of SYNGAP1 expression in mice and human neurons by redirecting alternative splicing. Neuron. 2023 05 17; 111(10):1637-1650.e5.
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Profiling lariat intermediates reveals genetic determinants of early and late co-transcriptional splicing. Mol Cell. 2022 12 15; 82(24):4681-4699.e8.
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Functional dynamic genetic effects on gene regulation are specific to particular cell types and environmental conditions. Elife. 2021 05 14; 10.
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RNA-binding protein syncrip regulates starvation-induced hyperactivity in adult Drosophila. PLoS Genet. 2021 02; 17(2):e1009396.
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Lifelong Reduction in LDL (Low-Density Lipoprotein) Cholesterol due to a Gain-of-Function Mutation in LDLR. Circ Genom Precis Med. 2021 02; 14(1):e003029.
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Alternative Splicing of Opioid Receptor Genes Shows a Conserved Pattern for 6TM Receptor Variants. Cell Mol Neurobiol. 2021 Jul; 41(5):1039-1055.