 Alternative Splicing
"Alternative Splicing" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A process whereby multiple RNA transcripts are generated from a single gene. Alternative splicing involves the splicing together of other possible sets of EXONS during the processing of some, but not all, transcripts of the gene. Thus a particular exon may be connected to any one of several alternative exons to form a mature RNA. The alternative forms of mature MESSENGER RNA produce PROTEIN ISOFORMS in which one part of the isoforms is common while the other parts are different.
| Descriptor ID |
D017398
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| MeSH Number(s) |
G02.111.087.750.700.100 G02.149.115.750.700.100 G03.495.839.700.100 G05.355.315.700.700.100
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| Concept/Terms |
Alternative Splicing- Alternative Splicing
- Alternative Splicings
- Splicings, Alternative
- Alternate Splicing
- Alternate Splicings
- Splicing, Alternate
- Splicings, Alternate
- RNA Splicing, Alternative
- Alternative RNA Splicing
- Alternative RNA Splicings
- RNA Splicings, Alternative
- Splicing, Alternative RNA
- Splicings, Alternative RNA
- Splicing, Alternative
Nested Transcripts- Nested Transcripts
- Nested Transcript
- Transcript, Nested
- Transcripts, Nested
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Below are MeSH descriptors whose meaning is more general than "Alternative Splicing".
Below are MeSH descriptors whose meaning is more specific than "Alternative Splicing".
This graph shows the total number of publications written about "Alternative Splicing" by people in this website by year, and whether "Alternative Splicing" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 1993 | 1 | 0 | 1 | | 1994 | 1 | 2 | 3 | | 1995 | 0 | 5 | 5 | | 1996 | 2 | 2 | 4 | | 1997 | 1 | 3 | 4 | | 1998 | 0 | 4 | 4 | | 1999 | 2 | 2 | 4 | | 2000 | 3 | 4 | 7 | | 2001 | 2 | 4 | 6 | | 2002 | 2 | 7 | 9 | | 2003 | 1 | 4 | 5 | | 2004 | 4 | 3 | 7 | | 2005 | 0 | 6 | 6 | | 2006 | 2 | 3 | 5 | | 2007 | 5 | 6 | 11 | | 2008 | 1 | 8 | 9 | | 2009 | 6 | 2 | 8 | | 2010 | 2 | 2 | 4 | | 2011 | 0 | 1 | 1 | | 2012 | 3 | 2 | 5 | | 2013 | 0 | 1 | 1 | | 2014 | 4 | 1 | 5 | | 2015 | 2 | 4 | 6 | | 2016 | 6 | 2 | 8 | | 2017 | 2 | 4 | 6 | | 2018 | 3 | 1 | 4 | | 2019 | 3 | 1 | 4 | | 2020 | 3 | 5 | 8 | | 2021 | 0 | 2 | 2 |
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Below are the most recent publications written about "Alternative Splicing" by people in Profiles.
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Findley AS, Monziani A, Richards AL, Rhodes K, Ward MC, Kalita CA, Alazizi A, Pazokitoroudi A, Sankararaman S, Wen X, Lanfear DE, Pique-Regi R, Gilad Y, Luca F. Functional dynamic genetic effects on gene regulation are specific to particular cell types and environmental conditions. Elife. 2021 05 14; 10.
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Chi W, Liu W, Fu W, Xia S, Heckscher ES, Zhuang X. RNA-binding protein syncrip regulates starvation-induced hyperactivity in adult Drosophila. PLoS Genet. 2021 02; 17(2):e1009396.
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Bjornsson E, Gunnarsdottir K, Halldorsson GH, Sigurdsson A, Arnadottir GA, Jonsson H, Olafsdottir EF, Niehus S, Kehr B, Sveinbjörnsson G, Gudmundsdottir S, Helgadottir A, Andersen K, Thorleifsson G, Eyjolfsson GI, Olafsson I, Sigurdardottir O, Saemundsdottir J, Jonsdottir I, Magnusson OT, Masson G, Stefansson H, Gudbjartsson DF, Thorgeirsson G, Holm H, Halldorsson BV, Melsted P, Norddahl GL, Sulem P, Thorsteinsdottir U, Stefansson K. Lifelong Reduction in LDL (Low-Density Lipoprotein) Cholesterol due to a Gain-of-Function Mutation in LDLR. Circ Genom Precis Med. 2021 02; 14(1):e003029.
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Piltonen M, Krokhotin A, Parisien M, Bérubé P, Djambazian H, Sladek R, Dokholyan NV, Shabalina SA, Diatchenko L. Alternative Splicing of Opioid Receptor Genes Shows a Conserved Pattern for 6TM Receptor Variants. Cell Mol Neurobiol. 2021 Jul; 41(5):1039-1055.
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Marcheva B, Perelis M, Weidemann BJ, Taguchi A, Lin H, Omura C, Kobayashi Y, Newman MV, Wyatt EJ, McNally EM, Fox JEM, Hong H, Shankar A, Wheeler EC, Ramsey KM, MacDonald PE, Yeo GW, Bass J. A role for alternative splicing in circadian control of exocytosis and glucose homeostasis. Genes Dev. 2020 08 01; 34(15-16):1089-1105.
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Schoch K, Tan QK, Stong N, Deak KL, McConkie-Rosell A, McDonald MT. Alternative transcripts in variant interpretation: the potential for missed diagnoses and misdiagnoses. Genet Med. 2020 07; 22(7):1269-1275.
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Li J, Xie Y, Cornelius S, Jiang X, Sando R, Kordon SP, Pan M, Leon K, Südhof TC, Zhao M, Araç D. Alternative splicing controls teneurin-latrophilin interaction and synapse specificity by a shape-shifting mechanism. Nat Commun. 2020 05 01; 11(1):2140.
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Metz PJ, Ching KA, Xie T, Delgado Cuenca P, Niessen S, Tatlock JH, Jensen-Pergakes K, Murray BW. Symmetric Arginine Dimethylation Is Selectively Required for mRNA Splicing and the Initiation of Type I and Type III Interferon Signaling. Cell Rep. 2020 02 11; 30(6):1935-1950.e8.
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Leon K, Cunningham RL, Riback JA, Feldman E, Li J, Sosnick TR, Zhao M, Monk KR, Araç D. Structural basis for adhesion G protein-coupled receptor Gpr126 function. Nat Commun. 2020 01 10; 11(1):194.
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Shah A, Li YI. Identification and Quantification of Splicing Quantitative Trait Loci. Methods Mol Biol. 2020; 2082:51-62.
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