"Thioguanine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.
| Descriptor ID |
D013866
|
| MeSH Number(s) |
D03.633.100.759.854
|
| Concept/Terms |
Thioguanine- Thioguanine
- 2-Amino-6-Purinethiol
- 2 Amino 6 Purinethiol
- Tioguanine
- 6-Thioguanine
- 6 Thioguanine
Tabloid- Tabloid
- Thioguanine Tabloid
- Thioguanin-GSK
- Thioguanin GSK
- ThioguaninGSK
|
Below are MeSH descriptors whose meaning is more general than "Thioguanine".
Below are MeSH descriptors whose meaning is more specific than "Thioguanine".
This graph shows the total number of publications written about "Thioguanine" by people in this website by year, and whether "Thioguanine" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 0 | 1 |
| 1995 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2001 | 1 | 0 | 1 |
| 2004 | 1 | 0 | 1 |
| 2005 | 0 | 2 | 2 |
| 2007 | 0 | 1 | 1 |
| 2012 | 1 | 0 | 1 |
| 2013 | 0 | 1 | 1 |
| 2015 | 1 | 0 | 1 |
| 2018 | 0 | 1 | 1 |
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click here.
Below are the most recent publications written about "Thioguanine" by people in Profiles.
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Evolving Considerations for Thiopurine Therapy for Inflammatory Bowel Diseases-A Clinical Practice Update: Commentary. Gastroenterology. 2019 01; 156(1):36-42.
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6-Thioguanine-loaded polymeric micelles deplete myeloid-derived suppressor cells and enhance the efficacy of T cell immunotherapy in tumor-bearing mice. Cancer Immunol Immunother. 2015 Aug; 64(8):1033-46.
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Randomised clinical trial: individualised vs. weight-based dosing of azathioprine in Crohn's disease. Aliment Pharmacol Ther. 2014 Jan; 39(2):163-75.
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Reduction-sensitive tioguanine prodrug micelles. Mol Pharm. 2012 Oct 01; 9(10):2812-8.
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Effect of allopurinol on clinical outcomes in inflammatory bowel disease nonresponders to azathioprine or 6-mercaptopurine. Clin Gastroenterol Hepatol. 2007 Feb; 5(2):209-14.
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Truncation of the C-terminus of human MLH1 blocks intracellular stabilization of PMS2 and disrupts DNA mismatch repair. DNA Repair (Amst). 2006 Mar 07; 5(3):347-61.
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Allopurinol safely and effectively optimizes tioguanine metabolites in inflammatory bowel disease patients not responding to azathioprine and mercaptopurine. Aliment Pharmacol Ther. 2005 Sep 01; 22(5):441-6.
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Genetic interactions between BLM and DNA ligase IV in human cells. J Biol Chem. 2004 Dec 31; 279(53):55433-42.
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Toxicity and efficacy of intensive chemotherapy for children with acute lymphoblastic leukemia (ALL) after first bone marrow or extramedullary relapse. Pediatr Blood Cancer. 2004 Oct; 43(5):571-9.
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Acute sinusoidal obstruction syndrome after 6-thioguanine therapy for Crohn's disease. Inflamm Bowel Dis. 2004 Sep; 10(5):652-4.