"Genes, APC" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Tumor suppressor genes located in the 5q21 region on the long arm of human chromosome 5. The mutation of these genes is associated with familial adenomatous polyposis (ADENOMATOUS POLYPOSIS COLI) and GARDNER SYNDROME, as well as some sporadic colorectal cancers.
| Descriptor ID |
D017491
|
| MeSH Number(s) |
G05.360.340.024.340.375.249.050 G05.360.340.024.340.415.400.050
|
| Concept/Terms |
Genes, APC- Genes, APC
- APC Gene
- APC Genes
- Gene, APC
- Genes, Adenomatous Polyposis Coli
|
Below are MeSH descriptors whose meaning is more general than "Genes, APC".
Below are MeSH descriptors whose meaning is more specific than "Genes, APC".
This graph shows the total number of publications written about "Genes, APC" by people in this website by year, and whether "Genes, APC" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 0 | 1 |
| 1998 | 1 | 0 | 1 |
| 1999 | 1 | 0 | 1 |
| 2002 | 2 | 1 | 3 |
| 2004 | 1 | 1 | 2 |
| 2005 | 1 | 1 | 2 |
| 2006 | 1 | 0 | 1 |
| 2011 | 1 | 0 | 1 |
| 2013 | 1 | 0 | 1 |
| 2014 | 0 | 1 | 1 |
| 2017 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Genes, APC" by people in Profiles.
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A novel mouse model of sporadic colon cancer induced by combination of conditional Apc genes and chemical carcinogen in the absence of Cre recombinase. Carcinogenesis. 2019 11 25; 40(11):1376-1386.
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Inhibition of WNT signaling in the bone marrow niche prevents the development of MDS in the Apcdel/+ MDS mouse model. Blood. 2017 06 01; 129(22):2959-2970.
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ß-Catenin promotes colitis and colon cancer through imprinting of proinflammatory properties in T cells. Sci Transl Med. 2014 Feb 26; 6(225):225ra28.
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Exploiting APC function as a novel cancer therapy. Curr Drug Targets. 2014 Jan; 15(1):90-102.
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Haploinsufficiency of del(5q) genes, Egr1 and Apc, cooperate with Tp53 loss to induce acute myeloid leukemia in mice. Blood. 2014 Feb 13; 123(7):1069-78.
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Apc mutation enhances PyMT-induced mammary tumorigenesis. PLoS One. 2011; 6(12):e29339.
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Inactivation of the vitamin D receptor in APC(min/+) mice reveals a critical role for the vitamin D receptor in intestinal tumor growth. Int J Cancer. 2012 Jan 01; 130(1):10-9.
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Involvement of KLF4 in sulforaphane- and iberin-mediated induction of p21(waf1/cip1). Nutr Cancer. 2009; 61(1):137-45.
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The I1307K APC polymorphism in Ashkenazi Jews with colorectal cancer: clinical and pathologic features. Cancer Genet Cytogenet. 2006 Aug; 169(1):33-8.
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Cathepsin E is a specific marker of dysplasia in APC mouse intestine. Tumour Biol. 2006; 27(1):36-42.