"Genes, Retinoblastoma" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Tumor suppressor genes located on human chromosome 13 in the region 13q14 and coding for a family of phosphoproteins with molecular weights ranging from 104 kDa to 115 kDa. One copy of the wild-type Rb gene is necessary for normal retinal development. Loss or inactivation of both alleles at this locus results in retinoblastoma.
| Descriptor ID |
D016161
|
| MeSH Number(s) |
G05.360.340.024.340.375.249.400 G05.360.340.024.340.415.400.400
|
| Concept/Terms |
Genes, Retinoblastoma- Genes, Retinoblastoma
- Rb Genes
- Retinoblastoma Genes
- Gene, Retinoblastoma
- Retinoblastoma Gene
- Genes, Rb
- Gene, Rb
- Rb Gene
|
Below are MeSH descriptors whose meaning is more general than "Genes, Retinoblastoma".
Below are MeSH descriptors whose meaning is more specific than "Genes, Retinoblastoma".
This graph shows the total number of publications written about "Genes, Retinoblastoma" by people in this website by year, and whether "Genes, Retinoblastoma" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 2 | 0 | 2 |
| 1996 | 1 | 0 | 1 |
| 1998 | 1 | 0 | 1 |
| 2000 | 0 | 1 | 1 |
| 2001 | 1 | 0 | 1 |
| 2004 | 1 | 0 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 1 | 0 | 1 |
| 2009 | 1 | 1 | 2 |
| 2010 | 3 | 0 | 3 |
| 2012 | 1 | 0 | 1 |
| 2014 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Genes, Retinoblastoma" by people in Profiles.
-
Subconjunctival Herniation of Fat Does Not Demonstrate Loss of RB Gene Expression. Am J Dermatopathol. 2018 Nov; 40(11):829-830.
-
Hyperactivated Wnt signaling induces synthetic lethal interaction with Rb inactivation by elevating TORC1 activities. PLoS Genet. 2014 May; 10(5):e1004357.
-
Functional inactivation of Rb sensitizes cancer cells to TSC2 inactivation induced cell death. Cancer Lett. 2013 Jan 01; 328(1):36-43.
-
E2f binding-deficient Rb1 protein suppresses prostate tumor progression in vivo. Proc Natl Acad Sci U S A. 2011 Jan 11; 108(2):704-9.
-
The RB tumor suppressor: a gatekeeper to hormone independence in prostate cancer? J Clin Invest. 2010 Dec; 120(12):4179-82.
-
Specific killing of Rb mutant cancer cells by inactivating TSC2. Cancer Cell. 2010 May 18; 17(5):469-80.
-
Elevated poly-(ADP-ribose)-polymerase activity sensitizes retinoblastoma-deficient cells to DNA damage-induced necrosis. Mol Cancer Res. 2009 Jul; 7(7):1099-109.
-
The rb pathway and cancer therapeutics. Curr Drug Targets. 2009 Jul; 10(7):581-9.
-
Retinoblastoma family genes. Oncogene. 2006 Aug 28; 25(38):5190-200.
-
The Rb tumor suppressor in stress responses and hematopoietic homeostasis. Cell Cycle. 2005 Jan; 4(1):42-5.