 Receptors, Serotonin, 5-HT3
"Receptors, Serotonin, 5-HT3" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A subclass of serotonin receptors that form cation channels and mediate signal transduction by depolarizing the cell membrane. The cation channels are formed from 5 receptor subunits. When stimulated the receptors allow the selective passage of SODIUM; POTASSIUM; and CALCIUM.
| Descriptor ID |
D044406
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| MeSH Number(s) |
D12.776.157.530.400.400.100.700 D12.776.543.550.425.500.100.700 D12.776.543.585.400.500.100.700 D12.776.543.750.051.750 D12.776.543.750.070.800.300 D12.776.543.750.720.300.800.300
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| Concept/Terms |
Receptors, Serotonin, 5-HT3- Receptors, Serotonin, 5-HT3
- Serotonin 3 Receptors
- Receptors, Serotonin 3
- Receptor, Serotonin 3
- Serotonin 3 Receptor
- 5-HT3 Receptor
- 5 HT3 Receptor
- 5-Hydroxytryptamine-3 Receptor
- 5 Hydroxytryptamine 3 Receptor
- Receptor, 5-Hydroxytryptamine-3
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Below are MeSH descriptors whose meaning is more general than "Receptors, Serotonin, 5-HT3".
- Chemicals and Drugs [D]
- Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
- Carrier Proteins [D12.776.157]
- Membrane Transport Proteins [D12.776.157.530]
- Ion Channels [D12.776.157.530.400]
- Ligand-Gated Ion Channels [D12.776.157.530.400.400]
- Cysteine Loop Ligand-Gated Ion Channel Receptors [D12.776.157.530.400.400.100]
- Receptors, Serotonin, 5-HT3 [D12.776.157.530.400.400.100.700]
- Membrane Proteins [D12.776.543]
- Membrane Glycoproteins [D12.776.543.550]
- Ion Channels [D12.776.543.550.425]
- Ligand-Gated Ion Channels [D12.776.543.550.425.500]
- Cysteine Loop Ligand-Gated Ion Channel Receptors [D12.776.543.550.425.500.100]
- Receptors, Serotonin, 5-HT3 [D12.776.543.550.425.500.100.700]
- Membrane Transport Proteins [D12.776.543.585]
- Ion Channels [D12.776.543.585.400]
- Ligand-Gated Ion Channels [D12.776.543.585.400.500]
- Cysteine Loop Ligand-Gated Ion Channel Receptors [D12.776.543.585.400.500.100]
- Receptors, Serotonin, 5-HT3 [D12.776.543.585.400.500.100.700]
- Receptors, Cell Surface [D12.776.543.750]
- Cysteine Loop Ligand-Gated Ion Channel Receptors [D12.776.543.750.051]
- Receptors, Serotonin, 5-HT3 [D12.776.543.750.051.750]
- Receptors, Biogenic Amine [D12.776.543.750.070]
- Receptors, Serotonin [D12.776.543.750.070.800]
- Receptors, Serotonin, 5-HT3 [D12.776.543.750.070.800.300]
- Receptors, Neurotransmitter [D12.776.543.750.720]
- Receptors, Biogenic Amine [D12.776.543.750.720.300]
- Receptors, Serotonin [D12.776.543.750.720.300.800]
- Receptors, Serotonin, 5-HT3 [D12.776.543.750.720.300.800.300]
Below are MeSH descriptors whose meaning is more specific than "Receptors, Serotonin, 5-HT3".
This graph shows the total number of publications written about "Receptors, Serotonin, 5-HT3" by people in this website by year, and whether "Receptors, Serotonin, 5-HT3" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 | | 1999 | 0 | 3 | 3 | | 2000 | 0 | 2 | 2 | | 2001 | 0 | 1 | 1 | | 2003 | 0 | 1 | 1 | | 2004 | 1 | 1 | 2 | | 2005 | 1 | 0 | 1 | | 2006 | 1 | 2 | 3 | | 2007 | 0 | 1 | 1 | | 2008 | 1 | 0 | 1 | | 2009 | 1 | 1 | 2 | | 2011 | 1 | 0 | 1 | | 2013 | 0 | 1 | 1 | | 2015 | 1 | 1 | 2 | | 2017 | 1 | 0 | 1 | | 2018 | 2 | 0 | 2 |
To return to the timeline, click here.
Below are the most recent publications written about "Receptors, Serotonin, 5-HT3" by people in Profiles.
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Basak S, Gicheru Y, Rao S, Sansom MSP, Chakrapani S. Cryo-EM reveals two distinct serotonin-bound conformations of full-length 5-HT3A receptor. Nature. 2018 11; 563(7730):270-274.
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Basak S, Gicheru Y, Samanta A, Molugu SK, Huang W, Fuente M, Hughes T, Taylor DJ, Nieman MT, Moiseenkova-Bell V, Chakrapani S. Cryo-EM structure of 5-HT3A receptor in its resting conformation. Nat Commun. 2018 02 06; 9(1):514.
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Chang EB, Rao MC. A new role for microbiota? Dulling the thrust of serotonin and 5-HT3 signaling cascade. Am J Physiol Gastrointest Liver Physiol. 2017 07 01; 313(1):G14-G15.
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Morton RA, Baptista-Hon DT, Hales TG, Lovinger DM. Agonist- and antagonist-induced up-regulation of surface 5-HT3 A receptors. Br J Pharmacol. 2015 Aug; 172(16):4066-77.
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Navari RM. 5-HT3 receptors as important mediators of nausea and vomiting due to chemotherapy. Biochim Biophys Acta. 2015 Oct; 1848(10 Pt B):2738-46.
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Navari RM. Management of chemotherapy-induced nausea and vomiting : focus on newer agents and new uses for older agents. Drugs. 2013 Mar; 73(3):249-62.
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Morton RA, Luo G, Davis MI, Hales TG, Lovinger DM. Fluorophore assisted light inactivation (FALI) of recombinant 5-HT3A receptor constitutive internalization and function. Mol Cell Neurosci. 2011 Jun; 47(2):79-92.
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Navari RM. Palonosetron: a second generation 5-hydroxytryptamine 3 receptor antagonist. Expert Opin Drug Metab Toxicol. 2009 Dec; 5(12):1577-86.
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Sanghvi M, Hamouda AK, Davis MI, Morton RA, Srivastava S, Pandhare A, Duddempudi PK, Machu TK, Lovinger DM, Cohen JB, Blanton MP. Hydrophobic photolabeling studies identify the lipid-protein interface of the 5-HT3A receptor. Biochemistry. 2009 Oct 06; 48(39):9278-86.
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Hu XQ, Lovinger DM. The L293 residue in transmembrane domain 2 of the 5-HT3A receptor is a molecular determinant of allosteric modulation by 5-hydroxyindole. Neuropharmacology. 2008 Jun; 54(8):1153-65.
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