Receptors, Serotonin, 5-HT3
"Receptors, Serotonin, 5-HT3" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A subclass of serotonin receptors that form cation channels and mediate signal transduction by depolarizing the cell membrane. The cation channels are formed from 5 receptor subunits. When stimulated the receptors allow the selective passage of SODIUM; POTASSIUM; and CALCIUM.
| Descriptor ID |
D044406
|
| MeSH Number(s) |
D12.776.157.530.400.400.100.700 D12.776.543.550.450.500.100.700 D12.776.543.585.400.500.100.700 D12.776.543.750.130.750 D12.776.543.750.670.800.300 D12.776.543.750.720.850.300
|
| Concept/Terms |
Receptors, Serotonin, 5-HT3- Receptors, Serotonin, 5-HT3
- 5-Hydroxytryptamine-3 Receptor
- 5 Hydroxytryptamine 3 Receptor
- Receptor, 5-Hydroxytryptamine-3
- Serotonin 3 Receptors
- Receptors, Serotonin 3
- Serotonin 3 Receptor
- 5-HT3 Receptor
- 5 HT3 Receptor
- Receptor, Serotonin 3
|
Below are MeSH descriptors whose meaning is more general than "Receptors, Serotonin, 5-HT3".
- Chemicals and Drugs [D]
- Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
- Carrier Proteins [D12.776.157]
- Membrane Transport Proteins [D12.776.157.530]
- Ion Channels [D12.776.157.530.400]
- Ligand-Gated Ion Channels [D12.776.157.530.400.400]
- Cysteine Loop Ligand-Gated Ion Channel Receptors [D12.776.157.530.400.400.100]
- Receptors, Serotonin, 5-HT3 [D12.776.157.530.400.400.100.700]
- Membrane Proteins [D12.776.543]
- Membrane Glycoproteins [D12.776.543.550]
- Ion Channels [D12.776.543.550.450]
- Ligand-Gated Ion Channels [D12.776.543.550.450.500]
- Cysteine Loop Ligand-Gated Ion Channel Receptors [D12.776.543.550.450.500.100]
- Receptors, Serotonin, 5-HT3 [D12.776.543.550.450.500.100.700]
- Membrane Transport Proteins [D12.776.543.585]
- Ion Channels [D12.776.543.585.400]
- Ligand-Gated Ion Channels [D12.776.543.585.400.500]
- Cysteine Loop Ligand-Gated Ion Channel Receptors [D12.776.543.585.400.500.100]
- Receptors, Serotonin, 5-HT3 [D12.776.543.585.400.500.100.700]
- Receptors, Cell Surface [D12.776.543.750]
- Cysteine Loop Ligand-Gated Ion Channel Receptors [D12.776.543.750.130]
- Receptors, Serotonin, 5-HT3 [D12.776.543.750.130.750]
- Receptors, Biogenic Amine [D12.776.543.750.670]
- Receptors, Serotonin [D12.776.543.750.670.800]
- Receptors, Serotonin, 5-HT3 [D12.776.543.750.670.800.300]
- Receptors, Neurotransmitter [D12.776.543.750.720]
- Receptors, Serotonin [D12.776.543.750.720.850]
- Receptors, Serotonin, 5-HT3 [D12.776.543.750.720.850.300]
Below are MeSH descriptors whose meaning is more specific than "Receptors, Serotonin, 5-HT3".
This graph shows the total number of publications written about "Receptors, Serotonin, 5-HT3" by people in this website by year, and whether "Receptors, Serotonin, 5-HT3" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2017 | 1 | 0 | 1 |
| 2018 | 2 | 0 | 2 |
| 2019 | 1 | 0 | 1 |
| 2020 | 1 | 0 | 1 |
| 2021 | 1 | 0 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Receptors, Serotonin, 5-HT3" by people in Profiles.
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Structure, Function and Physiology of 5-Hydroxytryptamine Receptors Subtype 3. Subcell Biochem. 2021; 96:373-408.
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High-resolution structures of multiple 5-HT3AR-setron complexes reveal a novel mechanism of competitive inhibition. Elife. 2020 10 16; 9.
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Molecular mechanism of setron-mediated inhibition of full-length 5-HT3A receptor. Nat Commun. 2019 07 19; 10(1):3225.
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Cryo-EM reveals two distinct serotonin-bound conformations of full-length 5-HT3A receptor. Nature. 2018 11; 563(7730):270-274.
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Cryo-EM structure of 5-HT3A receptor in its resting conformation. Nat Commun. 2018 02 06; 9(1):514.
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A new role for microbiota? Dulling the thrust of serotonin and 5-HT3 signaling cascade. Am J Physiol Gastrointest Liver Physiol. 2017 07 01; 313(1):G14-G15.
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Agonist- and antagonist-induced up-regulation of surface 5-HT3 A receptors. Br J Pharmacol. 2015 Aug; 172(16):4066-77.
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5-HT3 receptors as important mediators of nausea and vomiting due to chemotherapy. Biochim Biophys Acta. 2015 Oct; 1848(10 Pt B):2738-46.
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Management of chemotherapy-induced nausea and vomiting : focus on newer agents and new uses for older agents. Drugs. 2013 Mar; 73(3):249-62.
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Fluorophore assisted light inactivation (FALI) of recombinant 5-HT3A receptor constitutive internalization and function. Mol Cell Neurosci. 2011 Jun; 47(2):79-92.