"Mice, Knockout" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Descriptor ID |
D018345
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MeSH Number(s) |
B01.050.050.136.500.500 B01.050.150.900.649.313.992.635.505.500.550.455 B01.050.150.900.649.313.992.635.505.500.800.500
|
Concept/Terms |
Mice, Knockout- Mice, Knockout
- Mice, Knock-out
- Knock-out Mice
- Mice, Knock out
- Mouse, Knockout
- Knockout Mouse
- Knockout Mice
|
Below are MeSH descriptors whose meaning is more general than "Mice, Knockout".
Below are MeSH descriptors whose meaning is more specific than "Mice, Knockout".
This graph shows the total number of publications written about "Mice, Knockout" by people in this website by year, and whether "Mice, Knockout" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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1994 | 0 | 2 | 2 |
1995 | 0 | 5 | 5 |
1996 | 1 | 6 | 7 |
1997 | 0 | 13 | 13 |
1998 | 0 | 20 | 20 |
1999 | 0 | 20 | 20 |
2000 | 0 | 30 | 30 |
2001 | 0 | 31 | 31 |
2002 | 0 | 52 | 52 |
2003 | 0 | 50 | 50 |
2004 | 0 | 56 | 56 |
2005 | 0 | 44 | 44 |
2006 | 0 | 60 | 60 |
2007 | 0 | 59 | 59 |
2008 | 0 | 53 | 53 |
2009 | 0 | 82 | 82 |
2010 | 0 | 83 | 83 |
2011 | 0 | 73 | 73 |
2012 | 0 | 81 | 81 |
2013 | 0 | 72 | 72 |
2014 | 0 | 92 | 92 |
2015 | 0 | 87 | 87 |
2016 | 0 | 60 | 60 |
2017 | 0 | 73 | 73 |
2018 | 0 | 49 | 49 |
2019 | 0 | 57 | 57 |
2020 | 0 | 58 | 58 |
2021 | 0 | 42 | 42 |
2022 | 0 | 6 | 6 |
2023 | 0 | 8 | 8 |
2024 | 1 | 14 | 15 |
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Below are the most recent publications written about "Mice, Knockout" by people in Profiles.
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Upregulated selenoprotein I during lipopolysaccharide-induced B cell activation promotes lipidomic changes and is required for effective differentiation into IgM-secreting plasma B cells. J Leukoc Biol. 2024 Jun 28; 116(1):6-17.
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Breast cancer exploits neural signaling pathways for bone-to-meninges metastasis. Science. 2024 Jun 21; 384(6702):eadh5548.
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Eomes expression identifies the early bone marrow precursor to classical NK cells. Nat Immunol. 2024 Jul; 25(7):1172-1182.
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The Musashi-1-type 2 deiodinase pathway regulates astrocyte proliferation. J Biol Chem. 2024 Jul; 300(7):107477.
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Genome-wide association studies with experimental validation identify a protective role for B lymphocytes against chronic post-surgical pain. Br J Anaesth. 2024 Aug; 133(2):360-370.
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Deficiency in non-classical major histocompatibility class II-like molecule, H2-O confers protection against Staphylococcus aureus in mice. PLoS Pathog. 2024 Jun; 20(6):e1012306.
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Active biointegrated living electronics for managing inflammation. Science. 2024 May 31; 384(6699):1023-1030.
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m6A RNA methylation regulates mitochondrial function. Hum Mol Genet. 2024 May 18; 33(11):969-980.
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CD80 on skin stem cells promotes local expansion of regulatory T cells upon injury to orchestrate repair within an inflammatory environment. Immunity. 2024 May 14; 57(5):1071-1086.e7.
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Mild Hypoxia Accelerates Cerebral Cavernous Malformation Disease Through CX3CR1-CX3CL1 Signaling. Arterioscler Thromb Vasc Biol. 2024 Jun; 44(6):1246-1264.