Gbetagamma-mediated prostacyclin production and cAMP-dependent protein kinase activation by endothelin-1 promotes vascular smooth muscle cell hypertrophy through inhibition of glycogen synthase kinase-3.

Gbetagamma-mediated prostacyclin production and cAMP-dependent protein kinase activation by endothelin-1 promotes vascular smooth muscle cell hypertrophy through inhibition of glycogen synthase kinase-3. J Biol Chem. 2007 Jul 06; 282(27):19518-25.

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subject areas

Adrenergic beta-Agonists
Animals
Autocrine Communication
Cyclic AMP-Dependent Protein Kinases
Cyclooxygenase 1
Endothelin-1
Enzyme Activation
Epoprostenol
Glycogen Synthase Kinase 3
GTP-Binding Protein beta Subunits
GTP-Binding Protein gamma Subunits
Hypertrophy
Isoproterenol
Membrane Proteins
Mitogen-Activated Protein Kinase 1
Mitogen-Activated Protein Kinase 3
Muscle, Smooth, Vascular
Myocytes, Smooth Muscle
Phosphorylation
Rats
Rats, Inbred WKY
Signal Transduction
Vasoconstrictor Agents

authors with profiles

Nickolai Dulin