"Enzyme Activation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Conversion of an inactive form of an enzyme to one possessing metabolic activity. It includes 1, activation by ions (activators); 2, activation by cofactors (coenzymes); and 3, conversion of an enzyme precursor (proenzyme or zymogen) to an active enzyme.
| Descriptor ID |
D004789
|
| MeSH Number(s) |
G02.111.263 G03.328
|
| Concept/Terms |
Enzyme Activation- Enzyme Activation
- Activation, Enzyme
- Activations, Enzyme
- Enzyme Activations
|
Below are MeSH descriptors whose meaning is more general than "Enzyme Activation".
Below are MeSH descriptors whose meaning is more specific than "Enzyme Activation".
This graph shows the total number of publications written about "Enzyme Activation" by people in this website by year, and whether "Enzyme Activation" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 16 | 17 |
| 1995 | 0 | 18 | 18 |
| 1996 | 0 | 14 | 14 |
| 1997 | 0 | 9 | 9 |
| 1998 | 0 | 17 | 17 |
| 1999 | 1 | 20 | 21 |
| 2000 | 0 | 26 | 26 |
| 2001 | 0 | 31 | 31 |
| 2002 | 1 | 31 | 32 |
| 2003 | 1 | 30 | 31 |
| 2004 | 0 | 31 | 31 |
| 2005 | 0 | 30 | 30 |
| 2006 | 0 | 23 | 23 |
| 2007 | 0 | 19 | 19 |
| 2008 | 0 | 23 | 23 |
| 2009 | 0 | 29 | 29 |
| 2010 | 0 | 27 | 27 |
| 2011 | 0 | 21 | 21 |
| 2012 | 0 | 24 | 24 |
| 2013 | 1 | 19 | 20 |
| 2014 | 0 | 13 | 13 |
| 2015 | 0 | 11 | 11 |
| 2016 | 0 | 5 | 5 |
| 2017 | 0 | 5 | 5 |
| 2018 | 0 | 5 | 5 |
| 2019 | 0 | 5 | 5 |
| 2020 | 0 | 1 | 1 |
| 2021 | 0 | 2 | 2 |
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Below are the most recent publications written about "Enzyme Activation" by people in Profiles.
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Fibroblast pyruvate carboxylase is required for collagen production in the tumour microenvironment. Nat Metab. 2021 11; 3(11):1484-1499.
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The chemotherapeutic CX-5461 primarily targets TOP2B and exhibits selective activity in high-risk neuroblastoma. Nat Commun. 2021 11 09; 12(1):6468.
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Activation of AMP-Activated Protein Kinases Prevents Atrial Fibrillation. J Cardiovasc Transl Res. 2021 06; 14(3):492-502.
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Staphylococcus aureus Exploits the Host Apoptotic Pathway To Persist during Infection. mBio. 2019 11 12; 10(6).
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?-6-Phosphogluconolactone, a Byproduct of the Oxidative Pentose Phosphate Pathway, Contributes to AMPK Activation through Inhibition of PP2A. Mol Cell. 2019 12 19; 76(6):857-871.e9.
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Inhibition of the IGF-1-PI3K-Akt-mTORC2 pathway in lipid rafts increases neuronal vulnerability in a genetic lysosomal glycosphingolipidosis. Dis Model Mech. 2019 05 23; 12(5).
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DNA damage-induced PARP1 activation confers cardiomyocyte dysfunction through NAD+ depletion in experimental atrial fibrillation. Nat Commun. 2019 03 21; 10(1):1307.
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PLK1 plays dual roles in centralspindlin regulation during cytokinesis. J Cell Biol. 2019 04 01; 218(4):1250-1264.
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Role of c-Jun terminal kinase (JNK) activation in influenza A virus-induced autophagy and replication. Virology. 2019 01 02; 526:1-12.
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Structural basis for activation of SAGA histone acetyltransferase Gcn5 by partner subunit Ada2. Proc Natl Acad Sci U S A. 2018 10 02; 115(40):10010-10015.