"Adenylate Cyclase Toxin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
One of the virulence factors produced by virulent BORDETELLA organisms. It is a bifunctional protein with both ADENYLYL CYCLASES and hemolysin components.
| Descriptor ID |
D037361
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| MeSH Number(s) |
D08.811.520.650.200.040 D23.946.123.946.040 D23.946.896.980.040
|
| Concept/Terms |
Adenylate Cyclase Toxin- Adenylate Cyclase Toxin
- Cyclase Toxin, Adenylate
- Toxin, Adenylate Cyclase
- Adenylate Cyclase-Hemolysin
- Adenylate Cyclase Hemolysin
- Cyclase-Hemolysin, Adenylate
- cyaA Toxin
- Toxin, cyaA
- cyaA Gene Product, Bordetella
- AC Toxin, Bordetella
- Bordetella AC Toxin
- Toxin, Bordetella AC
- Ac-Hly, Bordetella
- Ac Hly, Bordetella
- Bordetella Ac-Hly
- cyaA Protein, Bordetella
- Bordetella cyaA Protein
- Protein, Bordetella cyaA
- Bordetella Adenylate Cyclase Toxin
- Cyclolysin
Bordetella pertussis Adenylate Cyclase Toxin- Bordetella pertussis Adenylate Cyclase Toxin
- Adenylate Cyclase-Haemolysin Bifunctional Protein, B. pertussis
- Adenylate Cyclase Haemolysin Bifunctional Protein, B. pertussis
- Pertussis Adenylate Cyclase-Haemolysin Bifunctional Protein
- Pertussis Adenylate Cyclase Haemolysin Bifunctional Protein
|
Below are MeSH descriptors whose meaning is more general than "Adenylate Cyclase Toxin".
Below are MeSH descriptors whose meaning is more specific than "Adenylate Cyclase Toxin".
This graph shows the total number of publications written about "Adenylate Cyclase Toxin" by people in this website by year, and whether "Adenylate Cyclase Toxin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 |
| 1996 | 0 | 1 | 1 |
| 1997 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2003 | 1 | 0 | 1 |
| 2005 | 1 | 1 | 2 |
| 2008 | 1 | 0 | 1 |
| 2009 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
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Below are the most recent publications written about "Adenylate Cyclase Toxin" by people in Profiles.
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The Fim and FhaB adhesins play a crucial role in nasal cavity infection and Bordetella pertussis transmission in a novel mouse catarrhal infection model. PLoS Pathog. 2022 04; 18(4):e1010402.
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Temperature-accelerated molecular dynamics gives insights into globular conformations sampled in the free state of the AC catalytic domain. Proteins. 2014 Oct; 82(10):2483-96.
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The adenylyl cyclase activity of anthrax edema factor. Mol Aspects Med. 2009 Dec; 30(6):423-30.
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Protein-protein docking and analysis reveal that two homologous bacterial adenylyl cyclase toxins interact with calmodulin differently. J Biol Chem. 2008 Aug 29; 283(35):23836-45.
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Structural basis for the interaction of Bordetella pertussis adenylyl cyclase toxin with calmodulin. EMBO J. 2005 Sep 21; 24(18):3190-201.
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Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor. EMBO J. 2005 Mar 09; 24(5):929-41.
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Structure-based inhibitor discovery against adenylyl cyclase toxins from pathogenic bacteria that cause anthrax and whooping cough. J Biol Chem. 2003 Jul 11; 278(28):25990-7.
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Protein kinase A-mediated phosphorylation of the beta 2-adrenergic receptor regulates its coupling to Gs and Gi. Demonstration in a reconstituted system. J Biol Chem. 2002 Aug 23; 277(34):31249-56.
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Transgenic mice with cardiac overexpression of alpha1B-adrenergic receptors. In vivo alpha1-adrenergic receptor-mediated regulation of beta-adrenergic signaling. J Biol Chem. 1997 Aug 22; 272(34):21253-9.
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Effects of hypothyroidism on brown adipose tissue adenylyl cyclase activity. Endocrinology. 1996 Dec; 137(12):5519-29.