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Zhen Tian

TitleAssistant Professor
InstitutionUniversity of Chicago
DepartmentRadiation and Cellular Oncology
AddressChicago IL 60637
Email
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    Collapse Overview 
    Collapse overview
    Dr. Zhen Tian is an Assistant Professor and board-certified Medical Physicist in the department of Radiation & Cellular Oncology at the University of Chicago. Her research focuses on the use of artificial intelligence and parallel computing to advance radiotherapy. She has developed expertise in GPU-based iterative low dose image reconstruction, ultra-fast Monte Carlo dose calculation and microscopic Monte Carlo simulation, AI-based autoplanning for radiotherapy. She has been awarded a R37 grant from NIH.

    If you are interested at collaboration or joining Dr. Tian's lab, please contact her by emails: zhen.tian@uchicago.edu; ztian@bsd.uchicago.edu.


    Collapse Biography 
    Collapse education and training
    University of Texas Southwestern Medical Center, Dallas, TxResidency12/2018Therapeutic Physics
    University of California San Diego , La Jolla, CAPostdoc09/2013Medical Physics
    Tsinghua University, Beijing, ChinaPhD06/2011Biomedical Engineering
    University of California San Diego, La Jolla, CAvisiting student01/2011Medical Physics
    Xi'an Jiaotong University, Xi'an, ChinaB.E.06/2006Biomedical Engineering

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Liu Y,Shen C,Wang T,Zhang J,Yang X,Liu T,Kahn S,Shu H,Tian Z. Automatic inverse treatment planning of Gamma Knife radiosurgery via deep reinforcement learning. Medical Physics. 2022; 49(5):2877-2889.
    2. Momin S, Lei Y, Tian Z, Wang T, Roper J, Kesarwala AH, Higgins K, Bradley JD, Liu T, Yang X. Lung tumor segmentation in 4D CT images using motion convolutional neural networks. Med Phys. 2021 Nov; 48(11):7141-7153. PMID: 34469001.
      View in: PubMed
    3. Xie H, Lei Y, Wang T, Tian Z, Roper J, Bradley JD, Curran WJ, Tang X, Liu T, Yang X. High through-plane resolution CT imaging with self-supervised deep learning. Phys Med Biol. 2021 07 14; 66(14). PMID: 34049297.
      View in: PubMed
    4. Lei Y, Tian Z, Wang T, Higgins K, Bradley JD, Curran WJ, Liu T, Yang X. Deep learning-based real-time volumetric imaging for lung stereotactic body radiation therapy: a proof of concept study. Phys Med Biol. 2020 12 18; 65(23):235003. PMID: 33080578.
      View in: PubMed
    5. Zhang Y, Tian Z, Lei Y, Wang T, Patel P, Jani AB, Curran WJ, Liu T, Yang X. Automatic multi-needle localization in ultrasound images using large margin mask RCNN for ultrasound-guided prostate brachytherapy. Phys Med Biol. 2020 10 09; 65(20):205003. PMID: 32640435.
      View in: PubMed
    6. Zeng Q, Fu Y, Tian Z, Lei Y, Zhang Y, Wang T, Mao H, Liu T, Curran WJ, Jani AB, Patel P, Yang X. Label-driven magnetic resonance imaging (MRI)-transrectal ultrasound (TRUS) registration using weakly supervised learning for MRI-guided prostate radiotherapy. Phys Med Biol. 2020 06 26; 65(13):135002. PMID: 32330922.
      View in: PubMed
    7. Tian Z, Yang X, Giles M, Wang T, Gao H, Butker E, Liu T, Kahn S. A preliminary study on a multiresolution-level inverse planning approach for Gamma Knife radiosurgery. Med Phys. 2020 Apr; 47(4):1523-1532. PMID: 32027029.
      View in: PubMed
    8. Tsai MY, Tian Z, Qin N, Yan C, Lai Y, Hung SH, Chi Y, Jia X. A new open-source GPU-based microscopic Monte Carlo simulation tool for the calculations of DNA damages caused by ionizing radiation --- Part I: Core algorithm and validation. Med Phys. 2020 Apr; 47(4):1958-1970. PMID: 31971258.
      View in: PubMed
    9. Lai Y, Tsai MY, Tian Z, Qin N, Yan C, Hung SH, Chi Y, Jia X. A new open-source GPU-based microscopic Monte Carlo simulation tool for the calculations of DNA damages caused by ionizing radiation - Part II: sensitivity and uncertainty analysis. Med Phys. 2020 Apr; 47(4):1971-1982. PMID: 31975390.
      View in: PubMed
    10. Zhang Y, He X, Tian Z, Jeong JJ, Lei Y, Wang T, Zeng Q, Jani AB, Curran WJ, Patel P, Liu T, Yang X. Multi-Needle Detection in 3D Ultrasound Images Using Unsupervised Order-Graph Regularized Sparse Dictionary Learning. IEEE Trans Med Imaging. 2020 07; 39(7):2302-2315. PMID: 31985414.
      View in: PubMed
    11. Lei Y, Dong X, Tian Z, Liu Y, Tian S, Wang T, Jiang X, Patel P, Jani AB, Mao H, Curran WJ, Liu T, Yang X. CT prostate segmentation based on synthetic MRI-aided deep attention fully convolution network. Med Phys. 2020 Feb; 47(2):530-540. PMID: 31745995.
      View in: PubMed
    12. Zhang Y, Chiu T, Dubas J, Tian Z, Lee P, Gu X, Yan Y, Sher D, Timmerman R, Zhao B. Benchmarking techniques for stereotactic body radiotherapy for early-stage glottic laryngeal cancer: LINAC-based non-coplanar VMAT vs. Cyberknife planning. Radiation Oncology. 2019; 14:193.
    13. Wang T, Lei Y, Tian Z, Dong X, Liu Y, Jiang X, Curran WJ, Liu T, Shu HK, Yang X. Deep learning-based image quality improvement for low-dose computed tomography simulation in radiation therapy. J Med Imaging (Bellingham). 2019 Oct; 6(4):043504. PMID: 31673567.
      View in: PubMed
    14. Zhang Y, Le A, Tian Z, Iqbal Z, Chiu T, Gu X, Pugachev A, Reynolds R, Park Y, Lin M, Stojadinovic S. Modeling Elekta VersaHD using the Varian Eclipse treatment planning system for photon beams: A single-institution experience. Journal of Applied Clinic Medical Physics. 2019; 20(10):33-42.
    15. Tian Z, Yen A, Zhou Z, Shen C, Albuquerque K, Hrycushko B. A machine-learning-based prediction model of fistula formation after interstitial brachytherapy for locally advanced gynecological malignancies. Brachytherapy. 2019 Jul - Aug; 18(4):530-538. PMID: 31103434.
      View in: PubMed
    16. Xu Y, Chen Y, Tian Z, Jia X, Zhou L. Metropolis Monte Carlo simulation scheme for fast scattered X-ray photon calculation in CT. Opt Express. 2019 Jan 21; 27(2):1262-1275. PMID: 30696195.
      View in: PubMed
    17. Yen A, Tian Z, Hrycushko B, Albuquerque K. Risk factors for fistula formation after interstitial brachytherapy for locally advanced gynecological cancers involving vagina. J Contemp Brachytherapy. 2018 Dec; 10(6):510-515. PMID: 30662473.
      View in: PubMed
    18. Qin N, Shen C, Tsai MY, Pinto M, Tian Z, Dedes G, Pompos A, Jiang SB, Parodi K, Jia X. Full Monte Carlo-Based Biologic Treatment Plan Optimization System for Intensity Modulated Carbon Ion Therapy on Graphics Processing Unit. Int J Radiat Oncol Biol Phys. 2018 01 01; 100(1):235-243. PMID: 29079118.
      View in: PubMed
    19. Chang J, Tian Z, Lu W, Gu X, Chen M, Jiang S. A novel geometry-dosimetry label fusion method in multi-atlas segmentation for radiotherapy: a proof-of-concept study. Phys. Med. Biol. 2017; 62:3656.
    20. Tian Z, Jiang SB, Jia X. Accelerated Monte Carlo simulation on the chemical stage in water radiolysis using GPU. Phys Med Biol. 2017 04 21; 62(8):3081-3096. PMID: 28323637.
      View in: PubMed
    21. Jia X, Tian Z, Xi Y, Jiang SB, Wang G. New concept on an integrated interior magnetic resonance imaging and medical linear accelerator system for radiation therapy. J Med Imaging (Bellingham). 2017 Jan; 4(1):015004. PMID: 28331888.
      View in: PubMed
    22. Tian Z, Li Y, Hassan-Rezaeian N, Jiang SB, Jia X. Moving GPU-OpenCL-based Monte Carlo dose calculation toward clinical use: Automatic beam commissioning and source sampling for treatment plan dose calculation. J Appl Clin Med Phys. 2017 Mar; 18(2):69-84. PMID: 28300376.
      View in: PubMed
    23. Qin N, Pinto M, Tian Z, Dedes G, Pompos A, Jiang SB, Parodi K, Jia X. Initial development of goCMC: a GPU-oriented fast cross-platform Monte Carlo engine for carbon ion therapy. Phys Med Biol. 2017 05 07; 62(9):3682-3699. PMID: 28140352.
      View in: PubMed
    24. Li Y, Tian Z, Song T, Wu Z, Liu Y, Jiang S, Jia X. A new approach to integrate GPU-based Monte Carlo simulation into inverse treatment plan optimization for proton therapy. Phys Med Biol. 2017 01 07; 62(1):289-305. PMID: 27991456.
      View in: PubMed
    25. Qin N, Botas P, Giantsoudi D, Schuemann J, Tian Z, Jiang SB, Paganetti H, Jia X. Recent developments and comprehensive evaluations of a GPU-based Monte Carlo package for proton therapy. Phys Med Biol. 2016 10 21; 61(20):7347-7362. PMID: 27694712.
      View in: PubMed
    26. Chi Y, Tian Z, Jia X. Modeling parameterized geometry in GPU-based Monte Carlo particle transport simulation for radiotherapy. Phys Med Biol. 2016 08 07; 61(15):5851-67. PMID: 27427297.
      View in: PubMed
    27. Tian Z, Zhang M, Hrycushko B, Albuquerque K, Jiang SB, Jia X. Monte Carlo dose calculations for high-dose-rate brachytherapy using GPU-accelerated processing. Brachytherapy. 2016 May-Jun; 15(3):387-398. PMID: 27216118.
      View in: PubMed
    28. Yan H, Tian Z, Shao Y, Jiang SB, Jia X. A new scheme for real-time high-contrast imaging in lung cancer radiotherapy: a proof-of-concept study. Phys Med Biol. 2016 Mar 21; 61(6):2372-88. PMID: 26943271.
      View in: PubMed
    29. Li Y, Hoisak J, Li N, Jiang C, Tian Z, Gautier Q, Zarepisheh M, Wu Z, Liu Y, Jia X, Hattangadi-Gluth J, Mell L, Jiang S, and Murphy J. Dosimetric benefit of adaptive re-planning in pancreatic cancer stereotactic body radiotherapy. Medical Dosimetry. 2015; 40(4):318-324.
    30. Song T, Staub D, Chen M, Lu W, Tian Z, Jia X, Li Y, Zhou L, Jiang SB, Gu X. Patient-specific dosimetric endpoints based treatment plan quality control in radiotherapy. Phys Med Biol. 2015 Nov 07; 60(21):8213-27. PMID: 26447829.
      View in: PubMed
    31. Tian Z, Li Y, Folkerts M, Shi F, Jiang SB, Jia X. An analytic linear accelerator source model for GPU-based Monte Carlo dose calculations. Phys Med Biol. 2015 Oct 21; 60(20):7941-67. PMID: 26418216.
      View in: PubMed
    32. Tian Z, Shi F, Folkerts M, Qin N, Jiang SB, Jia X. A GPU OpenCL based cross-platform Monte Carlo dose calculation engine (goMC). Phys Med Biol. 2015 Oct 07; 60(19):7419-35. PMID: 26352012.
      View in: PubMed
    33. Tian Z, Peng F, Folkerts M, Tan J, Jia X, Jiang SB. Multi-GPU implementation of a VMAT treatment plan optimization algorithm. Med Phys. 2015 Jun; 42(6):2841-52. PMID: 26127037.
      View in: PubMed
    34. Li Y, Tian Z, Shi F, Song T, Wu Z, Liu Y, Jiang S, Jia X. A new Monte Carlo-based treatment plan optimization approach for intensity modulated radiation therapy. Phys Med Biol. 2015 Apr 07; 60(7):2903-19. PMID: 25776792.
      View in: PubMed
    35. Tian Z, Graves YJ, Jia X, Jiang SB. Automatic commissioning of a GPU-based Monte Carlo radiation dose calculation code for photon radiotherapy. Phys Med Biol. 2014 Nov 07; 59(21):6467-86. PMID: 25295381.
      View in: PubMed
    36. Lu W, Yan H, Gu X, Tian Z, Luo O, Yang L, Zhou L, Cervino L, Wang J, Jiang S, Jia X. Reconstructing cone-beam CT with spatially varying qualities for adaptive radiotherapy: a proof-of-principle study. Phys Med Biol. 2014 Oct 21; 59(20):6251-66. PMID: 25255957.
      View in: PubMed
    37. Zarepisheh M, Long T, Li N, Tian Z, Romeijn HE, Jia X, Jiang SB. A DVH-guided IMRT optimization algorithm for automatic treatment planning and adaptive radiotherapy replanning. Med Phys. 2014 Jun; 41(6):061711. PMID: 24877806.
      View in: PubMed
    38. Li N, Zarepisheh M, Uribe-Sanchez A, Moore K, Tian Z, Zhen X, Graves YJ, Gautier Q, Mell L, Zhou L, Jia X, Jiang S. Automatic treatment plan re-optimization for adaptive radiotherapy guided with the initial plan DVHs. Phys Med Biol. 2013 Dec 21; 58(24):8725-38. PMID: 24301071.
      View in: PubMed
    39. Townson RW, Jia X, Tian Z, Graves YJ, Zavgorodni S, Jiang SB. GPU-based Monte Carlo radiotherapy dose calculation using phase-space sources. Phys Med Biol. 2013 Jun 21; 58(12):4341-56. PMID: 23732697.
      View in: PubMed
    40. Jia X, Tian Z, Lou Y, Sonke JJ, Jiang SB. Four-dimensional cone beam CT reconstruction and enhancement using a temporal nonlocal means method. Med Phys. 2012 Sep; 39(9):5592-602. PMID: 22957625.
      View in: PubMed
    41. Tian Z, Jia X, Yuan K, Pan T, Jiang SB. Low-dose CT reconstruction via edge-preserving total variation regularization. Phys Med Biol. 2011 Sep 21; 56(18):5949-67. PMID: 21860076.
      View in: PubMed
    42. Tian Z, Jia X, Dong B, Lou Y, Jiang SB. Low-dose 4DCT reconstruction via temporal nonlocal means. Med Phys. 2011 Mar; 38(3):1359-65. PMID: 21520846.
      View in: PubMed
    43. Yuan K, Tian Z, Zou J, Bai Y, You Q. Brain CT image database building for computer-aided diagnosis using content-based image retrieval. Information Processing & Management. 2011; 47(2):176-185.
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