 beta-Lactams
"beta-Lactams" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Four-membered cyclic AMIDES, best known for the PENICILLINS based on a bicyclo-thiazolidine, as well as the CEPHALOSPORINS based on a bicyclo-thiazine, and including monocyclic MONOBACTAMS. The BETA-LACTAMASES hydrolyze the beta lactam ring, accounting for BETA-LACTAM RESISTANCE of infective bacteria.
| Descriptor ID |
D047090
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| MeSH Number(s) |
D02.065.589.099 D02.886.108 D04.075.080.875.099.221
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "beta-Lactams".
Below are MeSH descriptors whose meaning is more specific than "beta-Lactams".
This graph shows the total number of publications written about "beta-Lactams" by people in this website by year, and whether "beta-Lactams" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1985 | 0 | 1 | 1 | | 1995 | 0 | 1 | 1 | | 2000 | 1 | 0 | 1 | | 2003 | 0 | 1 | 1 | | 2004 | 0 | 1 | 1 | | 2007 | 1 | 0 | 1 | | 2009 | 0 | 1 | 1 | | 2012 | 2 | 0 | 2 |
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Below are the most recent publications written about "beta-Lactams" by people in Profiles.
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Ziervogel BK, Roux B. The binding of antibiotics in OmpF porin. Structure. 2013 Jan 08; 21(1):76-87.
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Zakrison TL, Hille DA, Namias N. Effect of body mass index on treatment of complicated intra-abdominal infections in hospitalized adults: comparison of ertapenem with piperacillin-tazobactam. Surg Infect (Larchmt). 2012 Feb; 13(1):38-42.
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Lan L, Murray TS, Kazmierczak BI, He C. Pseudomonas aeruginosa OspR is an oxidative stress sensing regulator that affects pigment production, antibiotic resistance and dissemination during infection. Mol Microbiol. 2010 Jan; 75(1):76-91.
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Juretschko S, Labombardi VJ, Lerner SA, Schreckenberger PC. Accuracies of beta-lactam susceptibility test results for Pseudomonas aeruginosa with four automated systems (BD Phoenix, MicroScan WalkAway, Vitek, and Vitek 2). J Clin Microbiol. 2007 Apr; 45(4):1339-42.
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Bolon MK, Morlote M, Weber SG, Koplan B, Carmeli Y, Wright SB. Glycopeptides are no more effective than beta-lactam agents for prevention of surgical site infection after cardiac surgery: a meta-analysis. Clin Infect Dis. 2004 May 15; 38(10):1357-63.
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Roy S, Higareda I, Angel-Muller E, Ismail M, Hague C, Adeyi B, Woods GL, Teppler H. Ertapenem once a day versus piperacillin-tazobactam every 6 hours for treatment of acute pelvic infections: a prospective, multicenter, randomized, double-blind study. Infect Dis Obstet Gynecol. 2003; 11(1):27-37.
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Atanasov BP, Mustafi D, Makinen MW. Protonation of the beta-lactam nitrogen is the trigger event in the catalytic action of class A beta-lactamases. Proc Natl Acad Sci U S A. 2000 Mar 28; 97(7):3160-5.
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Vakulenko SB, Tóth M, Taibi P, Mobashery S, Lerner SA. Effects of Asp-179 mutations in TEMpUC19 beta-lactamase on susceptibility to beta-lactams. Antimicrob Agents Chemother. 1995 Aug; 39(8):1878-80.
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Lerner SA, Quinn JP. Emergence of resistance to beta-lactam antibiotics in Pseudomonas aeruginosa during treatment with new beta-lactams. Chemioterapia. 1985 Feb; 4(1):95-101.
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