 Ether-A-Go-Go Potassium Channels
"Ether-A-Go-Go Potassium Channels" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of voltage-gated potassium channels that are characterized by long N-terminal and C-terminal intracellular tails. They are named from the Drosophila protein whose mutation causes abnormal leg shaking under ether anesthesia. Their activation kinetics are dependent on extracellular MAGNESIUM and PROTON concentration.
| Descriptor ID |
D051638
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| MeSH Number(s) |
D12.776.157.530.400.600.900.249 D12.776.543.550.425.750.900.249 D12.776.543.585.400.750.900.249
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| Concept/Terms |
Ether-A-Go-Go Potassium Channels- Ether-A-Go-Go Potassium Channels
- Ether A Go Go Potassium Channels
- Potassium Channels, Ether-A-Go-Go
- Eag-Related Potassium Channels
- Eag Related Potassium Channels
- Potassium Channels, Eag-Related
- ERG Potassium Channels
- Potassium Channels, ERG
- Eag Potassium Channels
- Potassium Channels, Eag
- Ether-A-Go-Go Related Potassium Channels
- Ether A Go Go Related Potassium Channels
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Below are MeSH descriptors whose meaning is more general than "Ether-A-Go-Go Potassium Channels".
Below are MeSH descriptors whose meaning is more specific than "Ether-A-Go-Go Potassium Channels".
This graph shows the total number of publications written about "Ether-A-Go-Go Potassium Channels" by people in this website by year, and whether "Ether-A-Go-Go Potassium Channels" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
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| 2000 | 0 | 2 | 2 | | 2001 | 0 | 1 | 1 | | 2003 | 0 | 1 | 1 | | 2005 | 1 | 0 | 1 | | 2006 | 2 | 0 | 2 | | 2008 | 2 | 0 | 2 | | 2009 | 2 | 0 | 2 | | 2010 | 1 | 0 | 1 | | 2011 | 1 | 1 | 2 | | 2013 | 0 | 1 | 1 | | 2015 | 1 | 2 | 3 | | 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Ether-A-Go-Go Potassium Channels" by people in Profiles.
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Vaddi DR, Piao L, Khan SA, Wang N, Prabhakar NR, Nanduri J. Hypoxia induced hERG trafficking defect linked to cell cycle arrest in SH-SY5Y cells. PLoS One. 2019; 14(4):e0215905.
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Labro AJ, Priest MF, Lacroix JJ, Snyders DJ, Bezanilla F. Kv3.1 uses a timely resurgent K(+) current to secure action potential repolarization. Nat Commun. 2015 Dec 17; 6:10173.
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Wang N, Kang HS, Ahmmed G, Khan SA, Makarenko VV, Prabhakar NR, Nanduri J. Calpain activation by ROS mediates human ether-a-go-go-related gene protein degradation by intermittent hypoxia. . 2016 Mar 01; 310(5):C329-36.
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Issa NP, Fisher WG, Narayanan JT. QT interval prolongation in a patient with LQT2 on levetiracetam. Seizure. 2015 Jul; 29:134-6.
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Doherty KR, Wappel RL, Talbert DR, Trusk PB, Moran DM, Kramer JW, Brown AM, Shell SA, Bacus S. Multi-parameter in vitro toxicity testing of crizotinib, sunitinib, erlotinib, and nilotinib in human cardiomyocytes. Toxicol Appl Pharmacol. 2013 Oct 01; 272(1):245-55.
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Ferrer T, Cordero-Morales JF, Arias M, Ficker E, Medovoy D, Perozo E, Tristani-Firouzi M. Molecular coupling in the human ether-a-go-go-related gene-1 (hERG1) K+ channel inactivation pathway. J Biol Chem. 2011 Nov 11; 286(45):39091-9.
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Lysakowski A, Gaboyard-Niay S, Calin-Jageman I, Chatlani S, Price SD, Eatock RA. Molecular microdomains in a sensory terminal, the vestibular calyx ending. J Neurosci. 2011 Jul 06; 31(27):10101-14.
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Rodriguez N, Amarouch MY, Montnach J, Piron J, Labro AJ, Charpentier F, Mérot J, Baró I, Loussouarn G. Phosphatidylinositol-4,5-bisphosphate (PIP(2)) stabilizes the open pore conformation of the Kv11.1 (hERG) channel. Biophys J. 2010 Aug 09; 99(4):1110-8.
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Nanduri J, Bergson P, Wang N, Ficker E, Prabhakar NR. Hypoxia inhibits maturation and trafficking of hERG K(+) channel protein: Role of Hsp90 and ROS. Biochem Biophys Res Commun. 2009 Oct 16; 388(2):212-6.
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Jo SH, Hong HK, Chong SH, Lee HS, Choe H. H(1) antihistamine drug promethazine directly blocks hERG K(+) channel. Pharmacol Res. 2009 Nov; 60(5):429-37.
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