Ether-A-Go-Go Potassium Channels
"Ether-A-Go-Go Potassium Channels" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of voltage-gated potassium channels that are characterized by long N-terminal and C-terminal intracellular tails. They are named from the Drosophila protein whose mutation causes abnormal leg shaking under ether anesthesia. Their activation kinetics are dependent on extracellular MAGNESIUM and PROTON concentration.
Descriptor ID |
D051638
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MeSH Number(s) |
D12.776.157.530.400.600.900.249 D12.776.543.550.425.750.900.249 D12.776.543.585.400.750.900.249
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Concept/Terms |
Ether-A-Go-Go Potassium Channels- Ether-A-Go-Go Potassium Channels
- Ether A Go Go Potassium Channels
- Potassium Channels, Ether-A-Go-Go
- Eag-Related Potassium Channels
- Eag Related Potassium Channels
- Potassium Channels, Eag-Related
- ERG Potassium Channels
- Potassium Channels, ERG
- Eag Potassium Channels
- Potassium Channels, Eag
- Ether-A-Go-Go Related Potassium Channels
- Ether A Go Go Related Potassium Channels
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Below are MeSH descriptors whose meaning is more general than "Ether-A-Go-Go Potassium Channels".
Below are MeSH descriptors whose meaning is more specific than "Ether-A-Go-Go Potassium Channels".
This graph shows the total number of publications written about "Ether-A-Go-Go Potassium Channels" by people in this website by year, and whether "Ether-A-Go-Go Potassium Channels" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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2000 | 0 | 2 | 2 | 2001 | 0 | 1 | 1 | 2003 | 0 | 1 | 1 | 2005 | 1 | 0 | 1 | 2006 | 2 | 0 | 2 | 2008 | 2 | 0 | 2 | 2009 | 2 | 0 | 2 | 2010 | 1 | 0 | 1 | 2011 | 1 | 1 | 2 | 2013 | 0 | 1 | 1 | 2015 | 1 | 2 | 3 | 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Ether-A-Go-Go Potassium Channels" by people in Profiles.
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Vaddi DR, Piao L, Khan SA, Wang N, Prabhakar NR, Nanduri J. Hypoxia induced hERG trafficking defect linked to cell cycle arrest in SH-SY5Y cells. PLoS One. 2019; 14(4):e0215905.
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Labro AJ, Priest MF, Lacroix JJ, Snyders DJ, Bezanilla F. Kv3.1 uses a timely resurgent K(+) current to secure action potential repolarization. Nat Commun. 2015 Dec 17; 6:10173.
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Wang N, Kang HS, Ahmmed G, Khan SA, Makarenko VV, Prabhakar NR, Nanduri J. Calpain activation by ROS mediates human ether-a-go-go-related gene protein degradation by intermittent hypoxia. Am J Physiol Cell Physiol. 2016 Mar 01; 310(5):C329-36.
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Issa NP, Fisher WG, Narayanan JT. QT interval prolongation in a patient with LQT2 on levetiracetam. Seizure. 2015 Jul; 29:134-6.
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Doherty KR, Wappel RL, Talbert DR, Trusk PB, Moran DM, Kramer JW, Brown AM, Shell SA, Bacus S. Multi-parameter in vitro toxicity testing of crizotinib, sunitinib, erlotinib, and nilotinib in human cardiomyocytes. Toxicol Appl Pharmacol. 2013 Oct 01; 272(1):245-55.
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Ferrer T, Cordero-Morales JF, Arias M, Ficker E, Medovoy D, Perozo E, Tristani-Firouzi M. Molecular coupling in the human ether-a-go-go-related gene-1 (hERG1) K+ channel inactivation pathway. J Biol Chem. 2011 Nov 11; 286(45):39091-9.
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Lysakowski A, Gaboyard-Niay S, Calin-Jageman I, Chatlani S, Price SD, Eatock RA. Molecular microdomains in a sensory terminal, the vestibular calyx ending. J Neurosci. 2011 Jul 06; 31(27):10101-14.
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Rodriguez N, Amarouch MY, Montnach J, Piron J, Labro AJ, Charpentier F, Mérot J, Baró I, Loussouarn G. Phosphatidylinositol-4,5-bisphosphate (PIP(2)) stabilizes the open pore conformation of the Kv11.1 (hERG) channel. Biophys J. 2010 Aug 09; 99(4):1110-8.
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Nanduri J, Bergson P, Wang N, Ficker E, Prabhakar NR. Hypoxia inhibits maturation and trafficking of hERG K(+) channel protein: Role of Hsp90 and ROS. Biochem Biophys Res Commun. 2009 Oct 16; 388(2):212-6.
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Jo SH, Hong HK, Chong SH, Lee HS, Choe H. H(1) antihistamine drug promethazine directly blocks hERG K(+) channel. Pharmacol Res. 2009 Nov; 60(5):429-37.
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